research A multi-omic single-cell landscape of perinatal mouse skin maps lineage specification and reveals shared dynamics in human fetal skin
Mouse and human skin development share similar fibroblast timelines.
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research Implanted hair-follicle-associated pluripotent (HAP) stem cells differentiating to keratinocytes, macrophages and endothelial cells accelerated cutaneous wound closure and suppressed scar formation in a mouse model
Implanted special stem cells from hair follicles helped heal wounds faster and with less scarring in mice.
research Neuroendocrine Controls of Keratin Expression in Human Skin
Neurohormones help control skin health and could treat skin disorders.
research Hair Strengthening Evaluation of Anisotropic Osmolite Solutions (Inositol + Arginine): Cross-Talk between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a µHair Follicle 3D Model
Inositol and arginine solutions improve hair follicle health and turnover.
research Finasteride Inhibits Human Prostate Cancer Cell Invasion through MMP2 and MMP9 Downregulation
Finasteride may reduce prostate cancer spread by lowering certain enzyme levels.
research Androgens and human hair growth
Androgens can cause hair growth in some areas and hair loss on the scalp.
research Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice
Mice with LSS deficiency showed hair loss and cataracts, similar to humans, and can help in understanding and treating this condition.
research TLR3 signaling modulates immunomodulatory property of human periodontal ligament stem cells.
TLR3 signaling enhances the immunosuppressive properties of human periodontal ligament stem cells.
research Molecular mechanisms of viral oncogenesis in humans
Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.
research Retinoid Metabolism Is Altered in Human and Mouse Cicatricial Alopecia
Altered retinoid metabolism in cicatricial alopecia suggests a balanced vitamin A diet may prevent the condition.
research A comparative study of materials assembled from recombinant K31 and K81 and extracted human hair keratins
Recombinant keratin materials may better promote skin cell differentiation than natural keratin.
research Therapeutic small extracellular vesicles from key human stem and immune cellular sources: A review
Small extracellular vesicles from stem and immune cells show promise for treating various diseases but face challenges in clinical use.
research Noninvasive method for assessing the human circadian clock using hair follicle cells
Scientists found a new, less invasive way to study body clocks using hair cells, which shows shift workers' body clocks don't match their lifestyles.
research Probing the Effects of Stress Mediators on the Human Hair Follicle
Stress-related substance P may lead to hair loss and negatively affect hair growth.
research Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles
Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.
research Regulatory T cells in inflammatory skin disease: from mice to humans
Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.
research Promotive Effect of Minoxidil Combined with All-trans Retinoic Acid (tretinoin) on Human Hair Growth in Vitro
Minoxidil and ATRA together boost hair growth more effectively than minoxidil alone.
research GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells
GLI2 increases follistatin production in human skin cells.
research Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro
Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.
research Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue
Sweat glands and hair follicles are structurally connected within a specific layer of skin fat.
research The Additive Effects of Minoxidil and Retinol on Human Hair Growth in Vitro
Minoxidil and retinol together help hair grow.
research Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial
Annurca apple supplement safely increases hair growth and keratin in humans.
research Differential expression and functionality of ATP-binding cassette transporters in the human hair follicle
Certain transporters are found in human hair follicles and may affect hair growth and loss.
research Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life
Male hormones cause different growth in identical human hair follicles due to their unique epigenetic characteristics.
research Melanocyte progenitor cells reside in human subcutaneous adipose tissue
Melanocyte progenitor cells are found in human fat tissue and can become mature melanocytes, which may help treat skin issues.
research In vivo penetration of bare and lipid-coated silica nanoparticles across the human stratum corneum
Lipid-coated silica nanoparticles penetrate human skin more deeply than bare silica nanoparticles.
research Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner
PDGF-BB helps young melanocytes grow but stops mature ones from growing, and it makes melanocytes more specialized.
research Model systems for the study of dermatophyte and non-dermatophyte invasion of human keratin.
Terbinafine effectively stops fungal invasion of human keratin.
research Ultrastructural immunolocalization of involucrin in the medulla and inner root sheath of the human hair
Involucrin helps strengthen the inner parts of human hair.
research Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor
A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.