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GlossaryHydrocortisone

corticosteroid hormone reducing inflammation and immune response

Hydrocortisone is a corticosteroid hormone produced by the adrenal glands and is commonly used as a medication to reduce inflammation and suppress the immune system. It is often applied topically to treat skin conditions like eczema and psoriasis, and can also be administered orally or via injection for conditions such as adrenal insufficiency and severe allergic reactions.

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Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

research Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro

58 citations , June 1987 in “Archives of Dermatological Research”

EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.

research Clobetasol Propionate, 0.05%, vs Hydrocortisone, 1%, for Alopecia Areata in Children

49 citations , November 2013 in “JAMA dermatology”

Clobetasol propionate, 0.05%, is more effective and safe for treating childhood alopecia areata than hydrocortisone, 1%.

research Cushing Syndrome from Percutaneous Absorption of 1% Hydrocortisone Ointment in Netherton Syndrome

42 citations , January 2007 in “Pediatric dermatology”

Low-potency steroids can cause serious side effects in people with skin conditions like Netherton syndrome.

research Adherence to topical hydrocortisone 17-butyrate 0.1% in different vehicles in adults with atopic dermatitis

16 citations , December 2008 in “Journal of The American Academy of Dermatology”

Adults with atopic dermatitis showed similar adherence to different forms of hydrocortisone cream, but actual use varied despite self-reports of near-perfect usage.

research Factors influencing hydrocortisone permeation into human hair follicles: Use of the skin sandwich system

16 citations , March 2008 in “International journal of pharmaceutics”

Different factors like pH, gel type, and chemical enhancers affect how well hydrocortisone gets into hair follicles, and less hydrated skin doesn't work well with the test method.

research The interaction of hydrocortisone and thyroxine during fetal adipose tissue differentiation: CCAAT enhancing binding protein expression and capillary cytodifferentiation.

12 citations , January 1999 in “Journal of Animal Science”

Glucocorticoids and thyroid hormones together are essential for fetal fat development.

research TREATMENT FOR ULERYTHEMA OPHRYOGENES WITH HYDROCORTISONE OINTMENT

4 citations , April 1955 in “Archives of Dermatology”

Hydrocortisone ointment effectively improved eyebrow skin and hair in a 10-year-old.

research Dermal safety comparison of 0.05% desonide cream and 1.0% hydrocortisone cream

2 citations , April 1993 in “Current Therapeutic Research”

Both creams are equally safe, but hydrocortisone may cause more visible blood vessels.

research Use of Topical Minoxidil, 17α-Estradiol and Hydrocortisone Butyrate in Frontal Fibrosing Alopecia

1 citations , May 2014 in “European Journal of Inflammation”

A lotion with minoxidil, hydrocortisone butyrate, and 17a-estradiol can improve or stabilize Frontal Fibrosing Alopecia in some cases, but there's no universally-accepted treatment yet.

Study on Toxicity of Hydrocortisone 17-Butyrate 21-Propionate: Subacute Toxicity in Dogs by Percutaneous Administration

research STUDIED ON TOXICITY OF HYDROCORTISONE 17-BUTYRATE 21-PROPIONATE : 6. Subacute Toxicity in Dogs by Percutaneous Adminisration

January 1981 in “The Journal of Toxicological Sciences”

Hydrocortisone 17-butyrate 21-propionate ointment caused reversible side effects like skin issues, weight gain, and organ changes in dogs.

Compatibility of Cetirizine Hydrochloride, Dutasteride, Hydrocortisone Acetate, Nicotinamide, Progesterone, and Pyridoxine Hydrochloride in TrichoSol, A Natural Vehicle for Hair Solutions

research Compatibility of Cetirizine Hydrochloride, Dutasteride, Hydrocortisone Acetate, Nicotinamide, Progesterone, and Pyridoxine Hydrochloride in TrichoSolTM, A Natural Vehicle for Hair Solutions.

October 2024 in “PubMed”

TrichoSolTM is safe for hair loss treatments with specific ingredient stability for up to 180 days.

research The Comparative Potency of Hydrocortisone Analogs in Suppressing Growth of Hair in the Rat121From the Departments of Dermatology and Syphilology and of Anatomy, University of Michigan Medical School, Ann Arbor, Michigan.2Supported in part by research grants from the National Institutes of Health, United States Public Health Service (A-131 (C5)), the University of Michigan Memorial-Phoenix Project #145 and The Upjohn Company.

9 citations , December 1958 in “Journal of Investigative Dermatology”

research [Growing of hair in alopecia areata & maligna after intracutaneous hydrocortisone injection].

23 citations , October 1958 in “PubMed”

research Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol

489 citations , June 2005 in “The FASEB Journal”

Human hair follicles can produce cortisol like the body's stress response system.

research The Human Sebocyte Culture Model Provides New Insights into Development and Management of Seborrhoea and Acne

198 citations , January 1998 in “Dermatology”

The human sebocyte culture model has improved understanding of oily skin and acne, and how they can be treated.

research Temporary hair removal in patients with hirsutism: a clinical study.

89 citations , March 1990 in “PubMed”

Shaving is the most effective temporary hair removal method for facial hirsutism.

research A method for culturing human hair follicle cells

88 citations , January 1981 in “British Journal of Dermatology”

A new method helps grow human hair cells using a cow eye lens.

research Role of Transepidermal and Transfollicular Routes in Percutaneous Absorption of Steroids: In vitro Studies on Human Skin

82 citations , January 1994 in “Skin Pharmacology and Physiology”

Hair follicles and glands significantly increase steroid absorption in skin.

research Hair growth promoting effect of Zizyphus jujuba essential oil

73 citations , March 2010 in “Food and Chemical Toxicology”

Zizyphus jujuba essential oil can promote hair growth.

research Hormonal control of pelage cycles in the short tailed weasel (Mustela erminea bangsi)

68 citations , April 1965 in “General and Comparative Endocrinology”

The pituitary gland controls seasonal fur color changes in weasels.

research Local Injection of Steroids and Hair Regrowth in Alopecias

57 citations , December 1960 in “Archives of Dermatology”

Steroid injections can help regrow hair in some alopecia cases.

Nonclassic Adrenal Hyperplasia: Clinical Features, Diagnosis, and Treatment

research Nonclassic adrenal hyperplasia

55 citations , August 2008 in “Reviews in endocrine and metabolic disorders”

Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.

research Successful Treatment of Alopecia Areata with Topical Calcipotriol

51 citations , January 2012 in “Annals of dermatology/Annals of Dermatology”

A boy with alopecia regrew hair using a vitamin D cream after other treatments failed.

High-Performance Liquid Chromatography–Diode Array and Electrospray-Mass Spectrometry Analysis of Non-Allowed Substances in Cosmetic Products for Preventing Hair Loss and Other Hormone-Dependent Skin Diseases

research High-performance liquid chromatography–diode array and electrospray-mass spectrometry analysis of non-allowed substances in cosmetic products for preventing hair loss and other hormone-dependent skin diseases

45 citations , June 2008 in “Journal of pharmaceutical and biomedical analysis”

The method effectively identifies banned substances in hair loss and skin disease cosmetics.

research Non-classic congenital adrenal hyperplasia

42 citations , April 2013 in “Steroids”

Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.

research Prolonged maintenance of human hair follicles in vitro in a serum-free medium

36 citations , October 1993 in “British Journal of Dermatology”

Human hair follicles can grow in a lab for at least 9 days without serum, keeping their natural characteristics.

research Methods for quantifying intrafollicular drug delivery: a critical appraisal

34 citations , July 2010 in “Expert Opinion on Drug Delivery”

The document concludes that there is no agreed-upon best method for measuring drug delivery within hair follicles and more research is needed to validate current techniques.

research Cutaneous Corticosteroid Injection and Amaurosis

34 citations , November 1974 in “Archives of Dermatology”

Smaller, diluted corticosteroid injections reduce the risk of vision loss.

research Skin l‐tryptophan‐2,3‐dioxygenase and rat hair growth

33 citations , August 1993 in “FEBS Letters”

A new enzyme in rats may help regulate hair growth.

research Hormonal Control of Pelage Cycles In The Mink

31 citations , November 1965 in “Journal of Mammalogy”

The pituitary gland is crucial for normal mink fur cycles.