5 citations
,
December 2011 in “Journal of Cosmetic Dermatology” Patients who have hair restoration surgery at different clinics are more likely to experience increased sensitivity after surgery.
April 2023 in “Journal of Investigative Dermatology” A new pain-measuring system using sensors and AI can effectively detect pain in mice, which may help assess pain in humans and develop treatments.
5 citations
,
July 2022 in “Journal of Clinical Medicine” Long COVID-19 patients with skin pain might have a nerve condition that responds to a medication called gabapentin.
1 citations
,
June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” The symposium highlighted the skin's role in sensing itch, pain, touch, and pleasure, and discussed new research and techniques for understanding and treating these sensations.
41 citations
,
April 2009 in “Journal of comparative neurology” P2X3-IR fibers are widespread in rat skin and likely help detect pain.
January 2025 in “Journal of the Egyptian Womenʼs Dermatologic Society” Higher substance P levels may cause discomfort in hair loss patients.
16 citations
,
November 2024 in “Human Genetics and Genomics Advances” Nociplastic pain is a complex, heritable trait with genetic links to chronic and neuropathic pain.
TRPV4 channels in the skin may enhance the effects of acupuncture.
September 2023 in “Journal of the American Academy of Dermatology” Oral difelikefalin significantly reduces itch in notalgia paresthetica.
140 citations
,
February 2014 in “Neuron” Delta opioid receptors help regulate touch sensation by reducing neurotransmitter release in the spinal cord.
50 citations
,
April 2021 in “Frontiers in Immunology” New therapies targeting skin neuroimmune interactions could treat neuropathic pain.
May 2026 in “The Journal of Headache and Pain” Inhibiting certain brain neurons may reduce pain and anxiety in trigeminal neuralgia.
June 2023 in “medRxiv (Cold Spring Harbor Laboratory)” Nociplastic type pain, common in Chronic Overlapping Pain Conditions, is a complex, heritable trait linked to 24 unique genetic factors and 127 genes, with potential shared mechanisms in cognitive, personality, and metabolic traits.
29 citations
,
November 2013 in “Expert Review of Dermatology” Sensitive skin often causes discomfort, affects many people, especially women and older adults, and should be managed with careful product selection.
13 citations
,
December 2010 in “Pharmacology Biochemistry and Behavior” Inhibiting certain enzymes made female rats more sensitive to low-level pain.
35 citations
,
January 2022 in “Frontiers in Neurology” Effective pain management in multiple sclerosis requires individualized treatment strategies.
Dexmedetomidine-loaded microneedles effectively reduce pain without sedation.
December 2025 in “Molecular Pain” Targeting the MC-5-HT-HTR2A axis may help treat chronic itching.
April 2026 in “ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)” July 2026 in “Current Medical Issues” Topical anesthetics don't effectively reduce pain during scalp PRP injections.
3 citations
,
December 2023 in “Pain Medicine” Peripheral nerve stimulation greatly reduced pain and improved skin symptoms in a CRPS patient.
August 2025 in “Scientific Reports” Itchy keloids on the chest are linked to more nerve fibers and substance P.
4 citations
,
May 2019 in “Journal of Cosmetic Dermatology” Using a smaller syringe causes less pain when giving an injection.
63 citations
,
February 2010 in “Journal of Neurophysiology” Microstimulation of certain facial and mouth nerves can evoke specific sensations, while deeper nerves may require multiple stimulations to affect perception.
96 citations
,
March 2003 in “Life Sciences” Atopic dermatitis patients have much higher acetylcholine levels in their skin, which may cause itching.
5 citations
,
August 2023 in “Skin Research and Technology” Hairy skin feels prickling more intensely than smooth skin.
2 citations
,
September 2024 in “Pharmaceuticals” Human placenta hydrolysate reduces inflammatory pain and nerve damage in mice.
March 2025 in “Pain Physician” Cooling the skin before injections reduces pain for patients with hair loss.
20 citations
,
January 2015 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” Lysophosphatidic acid affects sensory neurons and may cause neuropathic pain and itch.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” HSD11b1 affects skin nerves and increases non-histaminergic itch.