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GlossaryHyperparathyroidism

condition where parathyroid glands overproduce hormone regulating calcium levels

Hyperparathyroidism is a condition where the parathyroid glands produce too much parathyroid hormone (PTH). This hormone regulates calcium levels in the blood, and its overproduction can lead to elevated calcium levels, potentially causing symptoms like bone pain, kidney stones, fatigue, and depression. There are two main types: primary hyperparathyroidism, often caused by a benign tumor on the gland, and secondary hyperparathyroidism, usually resulting from another condition like chronic kidney disease.

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research Parathyroid adenoma with coeliac disease: primary or quaternary hyperparathyroidism? Gruczolak przytarczyc i choroba trzewna: pierwotna czy czwartorzędowa nadczynność przytarczyc?

January 2012

A gluten-free diet and removing the parathyroid adenoma helped a girl with coeliac disease and high calcium levels start puberty.

research Idiopathic hypoparathyroidism with extensive intracranial calcification in children

3 citations , April 2017 in “Medicine”

An 11-year-old boy in Saudi Arabia has a rare case of hypoparathyroidism with severe brain calcifications but normal development and no known cause.

research Hypoparathyroidism as the single major component for decades of autoimmune polyglandular syndrome type 1

2 citations , December 2020 in “Endocrinology, diabetes & metabolism case reports”

A man with hypoparathyroidism had other health issues that led to a diagnosis of a rare autoimmune disorder, APS-1.

research IDIOPATHIC HYPOPARATHYROIDISM; A REPORT OF 2 CASES

50 citations , January 1941 in “Annals of Internal Medicine”

Idiopathic hypoparathyroidism is rare and can be managed with dihydrotachysterol.

research Mucocutaneous manifestations of acquired hypoparathyroidism: An observational study

20 citations , January 2012 in “Indian Journal of Endocrinology and Metabolism”

Most patients with acquired hypoparathyroidism after neck surgery had hair, nail, and skin issues.

research Case Report: Exceptional Association of Leydig Cell Ovarian Tumor and Primary Hyperparathyroidism in a Postmenopausal Patient

May 2021 in “Journal of the Endocrine Society”

A woman with a rare ovarian tumor and hyperparathyroidism improved after surgery, highlighting the need for reporting unusual cases to understand and manage rare diseases.

research Occurrence of Klinefelter Syndrome Mosaic 45,X/46,XY/47,XXY/48,XXYY/48,XXXY and Primary Hyperparathyroidism

March 2021 in “AACE clinical case reports”

A man with both Klinefelter syndrome and primary hyperparathyroidism showed a rare combination of symptoms and genetic patterns.

research Complete Pseudo-Anodontia in an Adult Woman with Pseudo-Hypoparathyroidism Type 1a: A New Additional Nonclassical Feature?

1 citations , November 2022 in “Diagnostics”

A woman with a rare hormone resistance condition also had missing teeth and hair loss, which might be new symptoms of her genetic disorder.

research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice¹

519 citations , October 1998 in “Endocrinology”

Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.

research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice

119 citations , October 1998 in “Endocrinology”

Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.

research Parathyroid adenoma with coeliac disease: primary or quaternary hyperparathyroidism?

2 citations , January 2012 in “PubMed”

A gluten-free diet and surgery fixed the girl's calcium levels and started puberty.

research VIRILISATION SECONDARY TO LEYDIG CELL OVARIAN TUMOR IN A POSTMENOPAUSAL WOMAN WITH PRIMARY HYPERPARATHYROIDISM

May 2025 in “Journal of the ASEAN Federation of Endocrine Societies”

Postmenopausal women with unusual hair growth should be checked for ovarian tumors.

research Diabetes, ovarian tumor, hyperparathyroidism, and papillary cancer: A chance association?

December 2014 in “Endocrinología y nutrición”

The woman's rare combination of diseases suggests an unknown factor may predispose individuals to multiple endocrine diseases.

research Lithium toxicity profi le: a systematic review and meta-analysis

550 citations , January 2012 in “Oxford University Research Archive (ORA) (University of Oxford)”

Lithium can cause some health issues, but severe risks are low.

research Adenoma of the Parathyroid Gland in Children

31 citations , May 1960 in “A M A Journal of Diseases of Children”

Parathyroid adenoma can cause hyperparathyroidism and hair loss in children.

research The eye and the skin in endocrine metabolic diseases

10 citations , December 2015 in “Clinics in Dermatology”

Diabetes can lead to blindness and skin problems, and managing blood sugar and blood pressure is crucial to prevent these complications.

research The clinical spectrum of parathyroid disease

8 citations , December 1981 in “Journal of The American Academy of Dermatology”

The document concludes that parathyroid diseases have a range of clinical features and outcomes, with some conditions being treatable and others having a high risk of mortality.

research Cutaneous Manifestations of Endocrine Disease

4 citations , November 2019 in “Harper's Textbook of Pediatric Dermatology”

Endocrine diseases in children can cause various skin and hair changes.

Experience of Intravenous Calcium Treatment and Long-Term Responses to Treatment in a Patient with Hereditary Vitamin D-Resistant Rickets Resulting from a Novel Mutation

research Experience of intravenous calcium treatment and long-term responses to treatment in a patient with hereditary vitamin D-resistant rickets resulting from a novel mutation

1 citations , May 2019 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism”

Intravenous calcium therapy is a safe and effective treatment for a rare type of rickets.

research SAT-724 Persistently Elevated Alkaline Phosphatase in an Older Woman with a History of Breast Cancer

October 2025 in “Journal of the Endocrine Society”

Stopping Viviscal, a hair loss product, normalized the woman's elevated alkaline phosphatase levels.

research Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin

March 2025 in “FEBS Journal”

Epiprofin suppresses parathyroid hormone gene activity, helping regulate calcium levels and could be a treatment target for hyperparathyroidism.

research Pathologies of the skin and its appendages in endocrine diseases

January 2016 in “Dermatology Review”

Endocrine disorders can cause various skin and hair issues.

research Autoimmune Polyglandular Syndrome Type 1 in Russian Patients: Clinical Variants and Autoimmune Regulator Mutations

62 citations , January 2010 in “Hormone research in paediatrics”

Genetic screening is crucial for accurately diagnosing APS-1 due to its varied symptoms.

research Novel and recurrent mutations in the AIRE gene of autoimmune polyendocrinopathy syndrome type 1 (APS1) patients

26 citations , September 2009 in “Clinical genetics”

Arab APS1 patients have unique and recurrent AIRE gene mutations.

research Methods of hair loss evaluation in patients with endocrine disorders.

6 citations , January 2011 in “PubMed”

The document concludes that most patients with endocrine disorders experience diffuse, non-scarring hair loss, with scarring hair loss being rare.

Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Syndrome (APECED) Due to AIRE T16M Mutation in a Consanguineous Greek Girl

research Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome (APECED) due to AIRET16M mutation in a consanguineous Greek girl

6 citations , January 2011 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism”

An 11-year-old Greek girl was diagnosed with a rare genetic disorder, highlighting the importance of genetic testing and family history.

research Medical and Surgical Hair Restoration

August 2016 in “CRC Press eBooks”

Before treating hair loss, it's crucial to diagnose and treat any underlying medical conditions that may be causing it.