74 citations
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July 1995 in “PubMed” Lowering homocyst(e)ine levels can reverse skin and hair lightening by restoring enzyme activity needed for pigmentation.
26 citations
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December 2022 in “Molecules” Nanotechnology can improve treatments for skin discoloration.
23 citations
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May 2017 in “Journal of the American Academy of Dermatology” FFA patients have fewer melanocytes and thinner skin compared to others.
5 citations
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August 2015 in “Sultan Qaboos University medical journal” Vitamin B12 deficiency can cause skin darkening and other symptoms, which improve with B12 supplements.
3 citations
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August 2017 in “Clinical case reports” A rare skin condition causes red and dark patches on the face and limbs.
1 citations
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May 2017 in “Journal of Stem Cell Research & Therapeutics” Pluripotent stem cells show promise for treating skin color loss disorders like vitiligo.
1 citations
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January 2021 in “Journal of Dermatology and Dermatologic Surgery” Taking Vitamin D supplements may increase the risk of skin darkening after laser hair removal.
November 2025 in “International Journal of Advanced Research” Platelet-rich plasma therapy effectively treated laser-induced skin lightening.
February 2024 in “International Journal For Multidisciplinary Research” Nanostructured lipid carriers are effective for treating hyperpigmentation in women aged 30-40.
119 citations
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May 1987 in “The Journal of Dermatologic Surgery and Oncology” Most patients' skin darkening after sclerotherapy fades on its own within 6-24 months.
77 citations
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August 1986 in “Archives of Dermatology” Vitamin B12 deficiency can cause skin and hair color changes, which are reversible with treatment.
15 citations
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July 2004 in “AIDS” Indinavir therapy can cause reversible skin, hair, and nail darkening.
11 citations
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August 1986 in “Archives of Dermatology” Vitamin B12 deficiency can cause skin and hair color changes, which can be reversed with treatment.
6 citations
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February 2014 in “Human & experimental toxicology” Testosterone injections can cause skin darkening and thickening.
5 citations
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January 2021 in “Daru” A woman had severe reactions to methotrexate, including skin issues and organ problems, but improved after 38 days in the hospital.
5 citations
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November 2013 in “Case reports in dermatology” A woman's skin darkened after using dutasteride and pimecrolimus for hair loss, but improved when she stopped the medications and protected her skin from light.
5 citations
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October 2012 in “Veterinary Pathology” A Doberman Pinscher had a rare form of autoimmune disease causing hair loss and other severe symptoms.
4 citations
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January 2025 in “Pharmaceutics” The gel is a safe and effective treatment for hyperpigmentation.
3 citations
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August 2023 in “The Journal of Pediatrics” Sodium valproate can rarely cause skin darkening, which may improve after stopping the drug.
3 citations
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March 2023 in “Cell Biology International” Stem cell-enriched fat grafts improve facial hyperpigmentation better than conventional grafts.
3 citations
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September 2017 in “Pediatric Dermatology” Avoiding allergens can improve skin and hair conditions in adults with allergic reactions.
2 citations
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March 2020 in “Skin” Using cidofovir cream for a rare skin disease can cause skin darkening.
2 citations
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January 2018 in “International Journal of Advanced Community Medicine” The cream effectively reduces hyperpigmentation and signs of aging without causing skin irritation.
2 citations
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October 2016 in “Nutrition in clinical practice” Vitamin B12 deficiency can cause facial dark spots that go away with treatment.
1 citations
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February 2025 in “Photodermatology Photoimmunology & Photomedicine” 830 nm LED light effectively treats and prevents skin redness and dark spots, while 590 nm LED light only helps prevent them.
1 citations
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April 2015 in “Neurology” Skin pigmentation increases in CRPS-affected areas and improves with symptom relief.
November 2024 in “Karnataka Pediatric Journal” Chikungunya can cause hyperpigmentation in children and should be considered in diagnosis.
September 2017 in “Pediatric Dermatology” The letter agrees that adults can get contact alopecia, which improves with allergen avoidance, and stresses early diagnosis to prevent permanent hair loss.
January 2015 in “Annals of dermatology/Annals of Dermatology” Using travoprost for glaucoma may cause extra hair growth and darker skin around the eyes, but these effects can reverse after stopping the drug.
January 2013 in “Journal of dermatology” A new medical syndrome may include skin changes, hair loss, sweating issues, bone malformations, leg swelling, and low cortisol.