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Did you mean Hypoxia-Inducible Factor 1-alpha?

GlossaryHypoxia-Inducible Factor 1-alpha

protein that helps cells adapt to low oxygen levels

Hypoxia-Inducible Factor 1-alpha (HIF-1α) is a protein that helps cells respond to low oxygen levels (hypoxia). It activates various genes that enable cells to adapt to hypoxic conditions, such as those involved in increasing blood supply and altering metabolism. This protein is crucial in processes like wound healing and can also play a role in diseases like cancer, where it can help tumors grow by improving their oxygen supply.

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research Overexpression of hypoxia-inducible factor-1α in hidradenitis suppurativa: the link between deviated immunity and metabolism

5 citations , March 2023 in “Archives of dermatological research”

Increased HIF-1α is linked to the inflammation and severity of hidradenitis suppurativa, suggesting treatments that lower HIF-1α could help.

research Hypoxia inducible factor-1a promotes trichogenic gene expression in human dermal papilla cells

1 citations , November 2022 in “Research Square (Research Square)”

A protein called HIF-1a helps control hair growth genes and could be targeted to treat hair loss.

research HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth

6 citations , January 2020 in “Skin Pharmacology and Physiology”

HIF-1α stimulators, like deferiprone, work as well as popular hair loss treatments, minoxidil and caffeine, in promoting hair growth.

KRT17 Promotes Endometrial Cancer Cell Migration and Angiogenesis by Regulating HIF-1α/VEGF Pathway

research KRT17 promotes endometrial cancer cell migration as well as angiogenesis by regulating HIF-1α/VEGF pathway

January 2023 in “European journal of gynaecological oncology”

KRT17 may be a new target for endometrial cancer treatment because it helps cancer cells move and form new blood vessels.

research Scarless wound healing: Transitioning from fetal research to regenerative healing

79 citations , January 2018 in “Wiley Interdisciplinary Reviews-Developmental Biology”

Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.

research Oxygen, Metabolism, and Regeneration: Lessons from Mice

35 citations , October 2017 in “Trends in Molecular Medicine”

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

research UP-03.25

October 2006 in “Urology”

Finasteride may help treat BPH by affecting certain biological markers.

Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia

research Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia

March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.

research A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers

8 citations , January 2020 in “International Journal of Cosmetic Science”

The combination of specific chemicals improves hair density in women.

research Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells

2 citations , January 2023 in “Scientific Reports”

HIF-1α is important for hair growth and could be a treatment target for hair loss.

research Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways

1 citations , July 2022 in “British Journal of Dermatology”

Targeting specific genes in certain pathways may help treat male pattern baldness.

research Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma

15 citations , September 2014 in “PloS one”

The study found that analyzing certain cell signaling pathways is not a reliable method to tell apart two types of skin tumors.

research FLCN regulates transferrin receptor 1 transport and iron homeostasis

1 citations , January 2021 in “Journal of biological chemistry/The Journal of biological chemistry”

FLCN helps control iron levels in cells.

research Spermidine/spermine-N¹-acetyltransferase: a key metabolic regulator

305 citations , March 2008 in “AJP Endocrinology and Metabolism”

SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.

research OBESITY-RELATED FACTORS INVOLVED IN ENDOPLASMIC RETICULUM STRESS INDUCTION IN ADIPOCYTES

January 2015 in “Durham e-Theses (Durham University)”

Adipose tissue changes in obesity can trigger stress in fat cells.

research Hypoxia in Cell Reprogramming and the Epigenetic Regulations

36 citations , January 2021 in “Frontiers in Cell and Developmental Biology”

Hypoxia and epigenetics are crucial for cell growth and tissue regeneration.

research Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

4 citations , June 2023 in “Frontiers in Aging”

Improving blood flow and oxygen levels in middle age may help prevent age-related diseases.

research Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

695 citations , October 2011 in “Cell stem cell”

Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.

17β-Estradiol Enhances Vascular Endothelial Growth Factor Production and Dihydrotestosterone Antagonizes the Enhancement via the Regulation of Adenylate Cyclase in Differentiated THP-1 Cells

research 17β-Estradiol Enhances Vascular Endothelial Growth Factor Production and Dihydrotestosterone Antagonizes the Enhancement via the Regulation of Adenylate Cyclase in Differentiated THP-1 Cells

18 citations , March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Estrogen increases blood vessel growth factor production, while testosterone blocks this increase.

Transforming Growth Factor-Beta in Stem Cells and Tissue Homeostasis

research Transforming growth factor-β in stem cells and tissue homeostasis

245 citations , January 2018 in “Bone Research”

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

research Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application

53 citations , September 2020 in “Stem Cell Research & Therapy”

New methods to improve the healing abilities of mesenchymal stem cells for disease treatment are promising but need more research.

research Establishment of an in vitro organoid model of dermal papilla of human hair follicle

44 citations , June 2018 in “Journal of Cellular Physiology”

Researchers developed a 3D model of human hair follicle cells that can help understand hair growth and test new hair loss treatments.

research Potential mechanisms of exercise in maintaining skin homeostasis disrupted by protein deficiency (Review)

March 2024 in “World Academy of Sciences Journal”

Exercise helps maintain healthy skin by promoting regeneration and reducing inflammation.

research Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential

September 2025 in “Current Issues in Molecular Biology”

IGF-1 can help regrow hair and may be a promising treatment for hair loss.

research Identification of differentially expressed genes affecting hair and cashmere growth in the Laiwu black goat by microarray

4 citations , September 2016 in “Molecular Medicine Reports”

Specific genes influence hair and cashmere growth in Laiwu black goats.

Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways

research Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways

1 citations , July 2023 in “International Journal of Molecular Sciences”

Treating fat stem cells with low oxygen boosts hair growth cell growth through specific signaling pathways.

Hypoxic Preconditioning Prevents Oxidative Stress-Induced Cell Death in Human Hair Follicle Stem Cells

research Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ

11 citations , July 2015 in “Gene”

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.