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GlossaryFOXA1

gene encoding a transcription factor influencing hair follicle development

FOXA1, or Forkhead Box A1, is a gene that encodes a transcription factor involved in regulating the expression of other genes. It plays a crucial role in the development and function of various tissues, including the liver, lungs, and prostate. In the context of hair biology, FOXA1 can influence hair follicle development and cycling, and its dysregulation may be implicated in conditions like alopecia.

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research Gene expression of FOXA1 and CCL2 in different phenotypes of infertile women with polycystic ovarian syndrome

December 2025 in “Egyptian Journal of Basic and Applied Sciences”

FOXA1 and CCL2 genes are more active in women with PCOS, varying by phenotype.

research Foxc1 reinforces quiescence in self-renewing hair follicle stem cells

142 citations , February 2016 in “Science”

Foxc1 helps keep hair follicle stem cells inactive, preventing hair loss.

Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis

research Control of hair follicle cell fate by underlying mesenchyme through a CSL–Wnt5a–FoxN1 regulatory axis

95 citations , July 2010 in “Genes & development”

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

research FOXE1, A New Transcriptional Target of GLI2 Is Expressed in Human Epidermis and Basal Cell Carcinoma

92 citations , May 2004 in “Journal of Investigative Dermatology”

FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program

research FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program

69 citations , January 2013 in “Frontiers in Immunology”

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

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