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Dynamic Changes in Fibroblast Subpopulations Drive Development of Radiation-Induced Skin Fibrosis Through the Fra/c-Jun Pathway

research 1493 Dynamic changes in fibroblast subpopulations drives development of radiation-induced skin fibrosis through the fra/c-jun pathway

April 2023 in “Journal of Investigative Dermatology”

Radiation treatment causes skin fibrosis by increasing certain fibroblast subpopulations, but using a c-Jun inhibitor or fat grafting can reduce this effect.

research Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development

25 citations , September 2018 in “Molecular Biology of the Cell”

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in Hair Follicle Morphogenesis and Homeostasis

research The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in the Hair Follicle Morphogenesis and Homeostasis

9 citations , April 2006 in “American Journal of Pathology”

SGK3 is essential for proper hair growth and health.

research Epidermal growth factor precursor retards hair growth cycle in vivo

January 2001

research What’s new in Birt–Hogg–Dubé syndrome?

December 2012 in “Expert review of dermatology”

New findings suggest the protein linked to Birt–Hogg–Dubé syndrome is important in cell signaling and could affect treatment understanding.

research Heparin-based sericin hydrogel–encapsulated basic fibroblast growth factor for in vitro and in vivo skin repair

22 citations , February 2023 in “Heliyon”

The hydrogel significantly speeds up wound healing and supports skin cell growth.

research Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects against Malignant Progression

15 citations , July 2013 in “Cell Reports”

Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.

research Genetic effects of vascular endothelial growth factor and its receptor 2 on feather maturity in three chicken breeds

1 citations , January 2019 in “British Poultry Science”

VEGF and VEGFR-2 genes influence feather maturity, and specific genetic markers can improve chicken breeding.

research An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15

15 citations , January 1991 in “Mammalian Genome”

Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development

research Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development

12 citations , June 2020 in “Frontiers in Cell and Developmental Biology”

The PP2A-B55α protein is essential for brain and skin development in embryos.

research Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation

7 citations , October 2011 in “BMC Cancer”

Overexpression of HDGF in melanocytes does not cause cancer.

research 486 Molecular Mechanisms of Type II Spiral Ganglion Neuron Development

April 2023 in “Journal of clinical and translational science”

research Endogenous Production of Heparin-Binding EGF-Like Growth Factor During Murine Partial-Thickness Burn Wound Healing

70 citations , March 2002 in “Journal of Burn Care & Rehabilitation”

HB-EGF and TGF-α help heal burns by boosting skin cell growth.

research Dicer- and BSC-dependent miRNAs during murine anagen development

1 citations , January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Dicer is crucial for hair growth in mice.

research Effects of FGF5-mediated LncRNA on the skin fibroblast growth of Liaoning Cashmere goats

July 2023 in “Indian Journal of Animal Health”

FGF-5 promotes Cashmere goat hair growth by increasing keratin genes and reducing certain LncRNA and target genes.

research Fibroblast Growth Factors in Epithelial Homeostasis and Repair

December 2016

Fibroblast Growth Factors (FGFs) help maintain and repair skin tissues, which is important for preventing diseases like inflammation, fibrosis, and cancer.

research Interleukin 6 and STAT3 regulate p63 isoform expression in keratinocytes during regeneration

11 citations , November 2015 in “Experimental Dermatology”

The conclusion is that the IL-6/STAT3 activation affects p63 expression in healing wounds, which may help in hair follicle regeneration.

Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

research 1367 Inhibition of the mitochondrial pyruvate carrier promotes ATF4–dependent stress responsive metabolic rewiring and cell cycle arrest in the human hair follicle

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking a key energy pathway in human hair follicles can trigger stress responses that stop cell growth.

research Ginsenoside Rg3 Up-regulates the Expression of Vascular Endothelial Growth Factor in Human Dermal Papilla Cells and Mouse Hair Follicles

20 citations , December 2013 in “PTR. Phytotherapy research/Phytotherapy research”

Ginsenoside Rg3 may help hair growth by increasing a growth-related protein in hair cells.

research Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

409 citations , May 1991 in “Genes & Development”

TGF-alpha affects skin thickness, hair growth, and may contribute to psoriasis and papilloma formation.

research Group IID, IIE, IIF and III secreted phospholipase A2s

23 citations , August 2018 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

research Impact of epidermal growth factor receptor and mitogen-activated kinase inhibition on hair follicles (HFs): partial HF immune privilege collapse and excessive interleukin-33 secretion

1 citations , July 2024 in “British Journal of Dermatology”

Inhibiting certain proteins harms hair follicle immunity and increases IL-33, affecting hair health.

research Deletion of an Enhancer in FGF5 is Associated With Ectopic Expression in Goat Hair Follicles and the Cashmere Growth Phenotype

1 citations , October 2020 in “Research Square (Research Square)”

A genetic variant in goats is linked to cashmere growth.

Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

research Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

11 citations , September 2019 in “Dermatologic Surgery”

A substance called Vascular Endothelial Growth Factor can protect certain hair follicle stem cells from damage caused by androgens, suggesting a new possible treatment for hair loss.