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research ISIDLB1777 - A novel ex vivo model of human hair follicle immune privilege collapse reveals the potential of farudodstat, a DHODH inhibitor, as a therapeutic for alopecia areata treatment

May 2023

Farudodstat may effectively treat alopecia areata by protecting hair follicles without harmful effects.

Analysis of Gene Expression in Isolated Single Hair Follicles Using Semiquantitative Reverse-Transcriptase Polymerase Chain Reaction

research Analysis of Gene Expression in Isolated Single Hair Follicles: An Approach Using Semiquantitative Reverse-Transcriptase—Polymerase Chain Reaction

May 1995 in “Journal of Investigative Dermatology”

Researchers developed a new way to measure gene activity in single hair follicles and found that a specific gene's activity changes with different amounts and times of treatment.

research Citrullination at the Inflammatory Skin Barrier

May 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

A potential treatment for atopic dermatitis could be to increase PADI1 expression to improve skin barrier function.

research Biochemical properties of red tilapia (Oreochromis niloticus) protein hydrolysates.

23 citations , January 2012 in “International Food Research Journal”

Tofacitinib effectively treated a woman's severe symptoms from a rare autoimmune condition.

research Study on kerantin association protein 8.1 gene expression of Liaoning cashere goats in skin and hair follicle

January 2014 in “China Feed”

Higher expression of the keratin-associated protein 8.1 gene in Liaoning cashmere goats is linked to finer cashmere fibers.

research CGF therapy: bridging androgenetic alopecia observations to psoriasis treatment via IL-17 pathway

October 2024 in “Stem Cell Research & Therapy”

CGF therapy may effectively treat psoriasis by reducing inflammation.

research Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

9 citations , August 2021 in “International journal of molecular sciences”

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

research Topical tacrolimus suppresses the expression of vascular endothelial growth factor and insulin-like growth factor-1 in late anagen

6 citations , June 2009 in “Clinical and Experimental Dermatology”

Topical tacrolimus reduces certain growth factors in hair follicles.

research Lectinhistochemistry of Dorsal Skin of Wistar-derived Hypotrichotic WBN/Ila-Ht Rats.

7 citations , January 1998 in “EXPERIMENTAL ANIMALS”

The skin of both rat strains showed similar lectin binding patterns.

research 270 A novel small compound HPH-15 antagonizes TGF-β/Smad signaling and ameliorates experimental skin fibrosis

April 2017 in “Journal of Investigative Dermatology”

HPH-15, a new compound, effectively reduces skin fibrosis in experiments without causing harm.

research Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?

May 2024 in “Frontiers in Immunology”

Type-2 immunity may influence skin diseases and could be targeted for treatment.

research Correction to “the Role of Hsa‐miR‐193a‐5p as an Important Factor for Control of Inositol in Alopecia Areata”

July 2025 in “Skin Research and Technology”

Hsa-miR-193a-5p is important in alopecia areata by promoting inflammation and involving specific genes in hair and immune function.

research Local infusion of infliximab for the treatment of acute joint inflammation

51 citations , July 2003 in “Annals of the Rheumatic Diseases”

Co-trimoxazole may help treat autoimmune diseases.

research Dihydrotestosterone, and Not Testosterone, Enhances the LPS-Induced Inflammatory Cytokine Gene Expression in Human Adipocytes

7 citations , April 2023 in “Biomedicines”

Dihydrotestosterone boosts inflammation in fat cells more than testosterone.

research Alymphoid cystic thymic dysgenesis - FOXN1 gene mutation: a rare case report of two siblings

November 2020 in “International journal of contemporary pediatrics”

Two siblings had a rare immune disorder caused by a FOXN1 gene mutation.

research Tissue and Circulating MicroRNA Co-expression Analysis Shows Potential Involvement of miRNAs in the Pathobiology of Frontal Fibrosing Alopecia

8 citations , July 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain microRNAs might help identify and understand Frontal Fibrosing Alopecia.

research Can the Hair Follicle Become a Model for Studying Selected Aspects of Human Ocular Immune Privilege?

21 citations , June 2011 in “Investigative Ophthalmology & Visual Science”

Hair follicles could help develop eye treatments by studying immune responses.

research Tissue-Specific Multi-Omics Integration Demonstrates Molecular Signatures Connecting Obesity to Immune Vulnerability

January 2026 in “Metabolites”

This study investigates the molecular connections between obesity and immune vulnerability by analyzing gene expression profiles across various tissues, including liver, skeletal muscle, blood, and adipose tissues. The research identifies differentially expressed genes (DEGs) and highlights the significant roles of RPL15 and RBM39 genes. It finds that cancer, particularly leukemia, lymphoma, and gastric cancer, is strongly associated with obesity. The study also reveals a host-pathogen interaction network with Influenza A virus showing the highest interaction. Key metabolites common across tissues include 2-Oxoglutarate, Adenosine, Succinate, and D-mannose. The findings suggest a link between obesity and immune-related processes, with potential overlaps in pathways related to viral infections, cytokine signaling, and insulin metabolism, indicating a possible interaction between immune and metabolic processes in obese individuals. Further experimental validation is needed to confirm these relationships.

research Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-α Production in LPS-Activated Macrophages via Suppression of NF-κB

54 citations , June 2008 in “Planta Medica”

Hinokitiol may help treat hair loss by reducing inflammation and promoting hair growth.

research Long non-coding RNA Xist contribution in systemic lupus erythematosus and rheumatoid arthritis

41 citations , January 2022 in “Clinical Immunology”

Females are more prone to lupus and arthritis due to X chromosome factors.

research Regulatory role of LEF-1 in the proliferation of Arbas White Cashmere goat dermal papilla cells

9 citations , April 2018 in “Canadian Journal of Animal Science”

LEF-1 boosts cell growth in goat hair follicles, aiding cashmere production.

research Identification of differentially expressed miRNAs in alopecia areata that target immune-regulatory pathways

14 citations , March 2017 in “Genes and immunity”

Certain microRNAs may help treat alopecia areata by targeting immune pathways.

The Use of Auto-Antibody Testing in the Evaluation of Interstitial Lung Disease: A Practical Approach for the Pulmonologist

research The use of auto-antibody testing in the evaluation of interstitial lung disease (ILD) – A practical approach for the pulmonologist

26 citations , February 2016 in “Respiratory Medicine”

Auto-antibody testing is a useful but not definitive tool in diagnosing interstitial lung diseases, and using a specific algorithm could make testing more cost-effective.

research 1345 A single-cell RNA map of perinatal developing mouse skin

April 2023 in “Journal of Investigative Dermatology”

The research mapped gene activity in developing mouse skin and found key markers for skin cell types and changes from fetal to early postnatal stages.