research Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity
Minoxidil analogs can be improved for hair growth inhibition by modifying specific parts of their structure.
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450-480 / 1000+ results research 2,5-Diazabicyclo[2.2.1]heptane in medicinal chemistry: a treasure trove of therapeutic opportunities
2,5-DBH shows promise for improving drugs in cancer, brain disorders, and infections.
research Non-invasive analysis of penetration and storage of Isoconazole nitrate in the stratum corneum and the hair follicles
Isoconazole nitrate stays effective in skin and hair follicles for up to two weeks after use.
research 5α-Reductase Inhibitors, Chemical and Clinical Models
Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.
research Product Pharmacology and Medical Actives in Achieving Therapeutic Benefits
Adding zinc to pyrithione zinc improves its effectiveness against scalp conditions like dandruff.
research Androgenic and anti-androgenic effects of progesterone derivatives with different halogens as substituents at the C-6 position
Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.
![Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear](/images/research/861159f1-7bd4-420c-a16b-4829458efe68/small/15592.jpg)
research Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche.
The compounds tested could potentially treat hair loss and alopecia.
research Interspecies variations in response to topical application of selected zinc compounds
Different zinc compounds cause varying levels of skin irritation in animals.
research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase
New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.
research Comparación de los efectos del D-004, imipramina y sertralina en el modelo de nado forzado en ratones Comparative effects of D-004, Imipramine and Sertraline in the forced swimming test in mice
D-004 shows moderate antidepressant effects but is less effective than Sertraline and Imipramine.
research New Aromatic Esters of Progesterone as Antiandrogens
New progesterone-based compounds can block male hormones.
research Inhibitory influence of agmatine on catamenial-like seizure susceptibility in progesterone withdrawn female rats
Agmatine may help reduce seizures linked to hormone changes in female rats.
research Novel modulatory effects of neurosteroids and benzodiazepines on excitatory and inhibitory neurons excitability: a multi-electrode array recording study
Neurosteroids and benzodiazepines reduce neuron excitability, with lasting effects on inhibitory neurons.
research [Study of gonadal hormone drugs in blocking filovirus entry of cells in vitro].
Some gonadal hormone drugs can block filovirus entry into cells.
research Biotransformation of tirilazad in human: 4. effect of finasteride on tirilazad clearance and reduced metabolite formation.
research Hypaphorine, an indole-3-acetic acid antagonist delivered by the ectomycorrhizal fungus Pisolithus tinctorius , induces reorganisation of actin and the microtubule cytoskeleton in Eucalyptus globulus ssp bicostata root hairs
Hypaphorine from a fungus changes the internal structure of Eucalyptus root hairs, stopping their growth.
research Application of Acyzol in the Context of Zinc Deficiency and Perspectives
Acyzol could help treat conditions caused by zinc deficiency.
research Experimental medication of equine ringworm due to Trichophyton equinum var. autotrophkum
Some treatments worked for horse ringworm, but mass treatment should focus on stopping infection spread, not just hair regrowth.
research Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship
Certain alkaloids could help create new coronavirus drugs.
research ChemInform Abstract: Rα‐Reductase Inhibitors‐ — The Finasteride Story
research Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics
Compound 4 is a promising treatment for hair loss with low toxicity.
research New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors
New compounds may help treat prostate issues without affecting androgen receptors.
research Treatment of hirsutism with cimetidine: a prospective randomized controlled trial
Cimetidine did not reduce hair growth in women with hirsutism.
research Sparse hairs below frontal hair line are early sign of androgenetic alopecia in men
Sparse hairs below frontal hairline can indicate early male balding.
research Herbal Powder Shampoo : A General Review
Herbal powder shampoo is effective, safe, and beneficial for various hair needs.
research The efficacy of an adjuvant norethisterone (jenapharm) therapy in endometrial cancer
Norethisterone (jenapharm) therapy is effective for endometrial cancer.
research N-methylformamide induces multiple organ toxicity in Fischer 344 rats
research Towards sustainable and scalable synthesis of amitriptyline hydrochloride, minoxidil, and pyrrolidinyl diaminopyrimidine oxide
research Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2
The compound 4c effectively inhibits the enzyme linked to hair loss.
research Advances in histamine-mediated allergy management: Expanding perspectives on cetirizine’s therapeutic, safety, and toxicological implications
Cetirizine is effective and safe for treating various allergies, with personalized dosing improving its use.