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Did you mean Immune Privilege?

GlossaryImmune Privilege

certain body areas limit immune responses to prevent tissue damage

Immune privilege refers to certain areas of the body, such as the eyes, brain, and hair follicles, where the immune system's activity is naturally limited to prevent damage to delicate tissues. This means that these areas can tolerate the introduction of antigens without eliciting a strong inflammatory immune response, which helps protect critical functions but can also make them vulnerable to infections or diseases.

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Resident T Cell Activation Leads to Human Hair Follicle Immune Privilege Loss Ex Vivo, Which Is Prevented by the DHODH Inhibitor Farudodstat: Relevance for Alopecia Areata

research Resident T cell activation leads to human hair follicle immune privilege loss ex vivo, which is prevented by the DHODH inhibitor farudodstat: relevance for alopecia areata

April 2026 in “Frontiers in Medicine”

Farudodstat may help prevent hair loss in alopecia areata by stopping immune attacks on hair follicles.

Resident T Cell Activation Leads to Human Hair Follicle Immune Privilege Loss Ex Vivo, Prevented by DHODH Inhibitor Farudodstat: Relevance for Alopecia Areata

research Image 1_Resident T cell activation leads to human hair follicle immune privilege loss ex vivo, which is prevented by the DHODH inhibitor farudodstat: relevance for alopecia areata.pdf

April 2026 in “Figshare”

Farudodstat can prevent hair follicle immune damage linked to alopecia areata.

research 1368 Does mitochondrial dysfunction drive immune privilege collapse in lichen planopilaris pathogenesis?

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mitochondrial dysfunction may contribute to chronic inflammation and immune system issues in Lichen planopilaris.

research Immune Privilege Collapse and Alopecia Development: Is Stress a Factor

51 citations , December 2017 in “Skin Appendage Disorders”

Stress may trigger hair loss by affecting immune protection in hair follicles.

research Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia?

39 citations , November 2009 in “Clinical and Experimental Dermatology”

Immune privilege collapse in hair follicles may cause permanent hair loss in certain conditions.

research Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

research 1338 Epidermal growth factor receptor protects from immune privilege collapse and scarring hair follicle destruction

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking EGFR can lead to hair loss due to inflammation and stem cell damage.

research 033 IL-15 is an unexpected guardian of hair follicle immune privilege and promotes human hair growth ex vivo

April 2021 in “Journal of Investigative Dermatology”

IL-15 helps protect hair follicles from immune attacks and encourages hair growth.

research The role of somatostatin expression in hair follicle immune privilege

January 2012

Somatostatin helps hair follicles suppress immune responses, which might aid in treating certain hair loss conditions.

research Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche

220 citations , June 2013 in “The Journal of Pathology”

Lichen planopilaris may be an autoimmune disease causing hair loss due to immune system issues in hair follicles.

research 546 Epidermal growth factor receptor as a key regulator of the immune privilege

November 2022 in “Journal of Investigative Dermatology”

EGFR is crucial for preventing hair follicle inflammation and hair loss.

research Do we need hair follicle stem cells and hair follicle neogenesis to cure common hair loss disorders?

3 citations , May 2008 in “Hair transplant forum international”

Common hair loss disorders may not need stem cell therapy, but could benefit from other treatments like hair cycle control and immune restoration therapy.

research Follicular Cell Implantation: An Emerging Cell Therapy for Hair Loss

13 citations , May 2005 in “Seminars in Plastic Surgery”

Follicular Cell Implantation might become a new treatment for hair loss and could lead to advances in organ regeneration.

research Hair Loss in Autoimmune Cutaneous Bullous Disorders

12 citations , May 2011 in “Dermatologic Clinics”

Hair loss in autoimmune blistering skin diseases varies and may regrow with disease control.

research Immune niches for hair follicle development and homeostasis

April 2024 in “Frontiers in physiology”

Immune cells are crucial for hair growth and preventing hair loss.

Exacerbation of Alopecia Areata During Pegylated Interferon Alpha-2b and Ribavirin Therapy, Possibly Due to the Collapse of Hair Follicle Immune Privilege

research Exacerbation of alopecia areata during pegylated interferon alpha-2b and ribavirin therapy, possibly due to the collapse of hair follicle immune privilege

10 citations , September 2014 in “European Journal of Dermatology”

A woman's hair loss worsened after starting hepatitis C treatment due to immune changes in her hair follicles.

research Scarring alopecia and nail loss in a patient with epidermolysis bullosa acquisita

1 citations , April 2024 in “The Journal of Dermatology”

Untreated epidermolysis bullosa acquisita can cause total hair and nail loss.

research Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance

March 2026 in “Frontiers in Medicine”

Different types of alopecia cause hair loss due to immune system issues, with some allowing regrowth and others causing permanent loss.

research Hair biology and hair loss disorders: An update and new concepts

December 2011

Recent discoveries have improved our understanding of hair loss, but challenges in treatment and knowledge among specialists still exist.

research Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack

253 citations , December 2007 in “Journal of Investigative Dermatology”

Hair follicles prevent NK cell attacks to avoid hair loss.

research Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata

106 citations , January 2013 in “Clinical and Developmental Immunology”

Alopecia areata is caused by immune system attacks on hair follicles, often triggered by viral infections.

research 59 Scarring alopecia is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Cancer treatment drugs can cause permanent hair loss by damaging hair follicle stem cells, but a specific inhibitor might reverse this effect.

research Immune privilege and alopecia areata

4 citations , April 2010 in “Expert review of dermatology”

Restoring immune privilege in hair follicles could help treat certain types of hair loss.

research Chemotherapy-Induced Alopecia Beyond Cytotoxicity: Hair Follicle Immune Privilege Collapse and JAK-STAT Signaling

May 2026 in “International Journal of Molecular Sciences”

Chemotherapy-induced hair loss may be linked to immune system changes, and certain treatments could help but need careful use.

Pre-Clinical In-Vitro Assays for High Throughput Screening of Drug Candidates for Protection and Restoration of Immune Privilege in Alopecia Areata

research 1419 Pre-clinical in-vitro assays for high throughput screening of drug candidates for protection and restoration of immune privilege in alopecia areata

April 2023 in “Journal of Investigative Dermatology”

The research developed methods to test drugs that could protect and restore hair follicle protection in a hair loss condition.

research 1432 IL-9/IL-9R signaling as a novel regulator of human hair follicle growth and immune privilege

April 2023 in “Journal of Investigative Dermatology”

IL-9/IL-9R signaling can negatively affect human hair growth and may be a target for treating hair loss conditions.

research Hair follicle immune privilege and its collapse in alopecia areata

134 citations , July 2020 in “Experimental dermatology”

Hair follicles are normally protected from the immune system, but when this protection fails, it can cause hair loss in alopecia areata.

Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse

research Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse

36 citations , April 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

A substance called VIP might protect hair follicles from being attacked by the immune system, and problems with VIP signaling could lead to hair loss in alopecia areata.

Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia

research 175 Understanding immune privilege in an inducible mouse model of primary cicatrcial alopecia

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study found that a key immune pathway protecting hair follicles is reduced in a mouse model of scarring hair loss.

research Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege

47 citations , December 2011 in “Experimental Dermatology”

CGRP may help protect hair follicles from immune system attacks, potentially slowing hair loss.