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GlossaryInflammasome Activation

process triggering immune response to harmful stimuli

Inflammasome activation refers to the process by which a group of proteins in the immune system, called inflammasomes, detect harmful stimuli like infections or cellular damage and trigger an inflammatory response. This activation leads to the production of molecules like cytokines that help fight off infections but can also contribute to inflammatory diseases if not properly regulated.

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Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

research Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles

22 citations , March 2017 in “Scientific reports”

Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.

research 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma

1 citations , April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

The Possible Role of PTEN-Induced Kinase 1-Mediated Mitophagy in Regulating Inflammasome Activation in the Pathogenesis of Alopecia Areata

research 1330 The possible role of PTEN-induced kinase 1-mediated mitophagy by regulating inflammasome activation in the pathogenesis of alopecia areata

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Activating mitophagy may help manage a key immune response involved in the hair loss condition alopecia areata.

research Aberrant inflammasome activation as a driving force of human autoimmune skin disease

3 citations , May 2023 in “Frontiers in immunology”

Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.

research 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis

April 2023 in “Journal of Investigative Dermatology”

PX-12 may help treat psoriasis by blocking inflammation and cell death.

research NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium

50 citations , August 2019 in “Cell Communication and Signaling”

NFAT5 triggers atherosclerosis under stress by activating inflammation in blood vessels.

research Baricitinib Attenuates IFN-γ and Polyinosinic:polycytidylic Acid‒Induced Mitochondrial Damage and Inflammasome Activation in Human Keratinocytes

August 2022 in “Journal of Investigative Dermatology”

Smart Fluids as Autophagy-Activating Photoprotectors: In Vitro Analysis of Dead Sea Water and Magnetized Saline Water Against Ultraviolet B (UVB)-Induced Photodamage in Human Keratinocytes

research Smart Fluids As Autophagy-Activating Photoprotectors: In Vitro Analysis of Dead Sea Water and Magnetized Saline Water Against Ultraviolet B (UVB)-Induced Photodamage in Human Keratinocytes

1 citations , April 2025 in “Cureus”

Dead Sea water and magnetized saline water can protect skin from UVB damage by activating autophagy.

research Novel TMEM173 Mutation and the Role of Disease Modifying Alleles

47 citations , December 2019 in “Frontiers in immunology”

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

research Genotoxic Agents: An Unexpected Effect on Healthy Epithelia

2 citations , December 2020 in “Developmental cell”

Chemotherapy drugs can cause abnormal growth and changes in healthy skin and gland cells.

research Characterization of novel TMEM173 mutation with additive IFIH1 risk allele

1 citations , August 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

A new mutation in the TMEM173 gene and a risk allele in IFIH1 cause a unique set of immune-related symptoms.

research 642 Uncovering the role of UV exposure history and genetics in determining skin sun damage

1 citations , April 2016 in “Journal of Investigative Dermatology”

UV photography can help identify people at higher risk for skin cancer, and male pattern baldness at age 45 is linked to a higher risk of certain skin cancers.

research 646 SOX4 is essential for melanoma tumorigenesis

April 2016 in “Journal of Investigative Dermatology”

SOX4 is crucial for the development of melanoma.

research The crosstalk between PTEN ‐induced kinase 1‐mediated mitophagy and the inflammasome in the pathogenesis of alopecia areata

6 citations , June 2023 in “Experimental Dermatology”

Targeting mitophagy may help treat alopecia areata by reducing inflammasome activation.

research Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation

51 citations , March 2019 in “Experimental Dermatology”

Matrix changes and increased MMPs contribute to skin inflammation in hidradenitis suppurativa.

research The many faces of interleukin-17 in inflammatory skin diseases

77 citations , April 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

IL-17 is a key target for treating inflammatory skin diseases, especially psoriasis.

Inflammation in Androgenetic Alopecia and Hair Loss: Linking Neurosciences, Endocrinology, and Dermatology

research Inflammation in androgenetic alopecia and hair loss: linking neurosciences-endocrinology-dermatology

1 citations , May 2012 in “Hair transplant forum international”

Hair loss in men may be caused by inflammation triggered by hormones, and treatments reducing inflammation could potentially promote hair growth.

research Hair follicle mesenchymal stem cell exosomal lncRNA H19 inhibited NLRP3 pyroptosis to promote diabetic mouse skin wound healing

13 citations , February 2023 in “Aging”

A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.

research Fermented Yeast Complex Extract Promotes Hair Regrowth by Decreasing Oxidative Stress

December 2025 in “Antioxidants”

Fermented Yeast Complex Extract helps regrow hair by reducing oxidative stress and inflammation.

research Acne-Associated Syndromes

January 2019 in “Springer eBooks”

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

research Inflammasome Proteins as Biomarkers of Injury and Disease

January 2014 in “Springer eBooks”

Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.

Oral Administration of Berberine Represses Macrophage Activation-Associated Benign Prostatic Hyperplasia: A Pivotal Involvement of the NF-κB

research Oral administration of berberine represses macrophage activation-associated benign prostatic hyperplasia: a pivotal involvement of the NF-κB

8 citations , August 2021 in “Aging”

Berberine may reduce prostate enlargement by blocking inflammation.

Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrest Growth of Gynecologic Cancers

research Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrests Growth of Gynecologic Cancers

16 citations , May 2020 in “Frontiers in pharmacology”

Minoxidil can stop the growth of ovarian cancer cells without harming the heart.

Advancements in Research on the Immune-Inflammatory Mechanisms Mediated by NLRP3 Inflammasome in Ischemic Stroke and the Regulatory Role of Natural Plant Products

research Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant products

18 citations , March 2024 in “Frontiers in Pharmacology”

Natural plant products like Proanthocyanidins and curcumin may help treat ischemic stroke by reducing inflammation.

research The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice

59 citations , July 2015 in “Journal of Immunology”

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

research Inflammasome Proteins Are Reliable Biomarkers of the Inflammatory Response in Aneurysmal Subarachnoid Hemorrhage

4 citations , August 2024 in “Cells”

Inflammasome proteins can predict inflammation and outcomes in aneurysmal subarachnoid hemorrhage.

research Proof-of-Principle Study of Inflammasome Signaling Proteins as Diagnostic Biomarkers of the Inflammatory Response in Parkinson’s Disease

17 citations , June 2023 in “Pharmaceuticals”

Inflammasome proteins may help diagnose and treat Parkinson's disease.

What 'Regenerative' Means in Aesthetic Medicine: A Narrative Literature Review Attempting to Demystify the Core Essence of Regenerative Aesthetics

research What “regenerative” means in aesthetic medicine: a narrative literature review attempting to demystify the core essence of regenerative aesthetics

February 2026 in “Plastic and Aesthetic Research”

Regenerative aesthetic medicine aims to restore tissue function, but needs more consistent evidence and standardized practices.

Identifying Key Components and Therapeutic Targets of the Immune System in Hidradenitis Suppurativa with an Emphasis on Neutrophils

research Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils

16 citations , September 2020 in “British journal of dermatology/British journal of dermatology, Supplement”

The article suggests that targeting specific immune pathways could help control and treat the skin disease hidradenitis suppurativa.

research Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology

February 2026 in “American Journal of Clinical Dermatology”

Radiotherapy can cause skin fibrosis, which is often overlooked and needs better treatment and evaluation.