November 2015 in “European Journal of Inflammation” Cicatricial alopecia, a permanent hair loss condition, is mainly caused by damage to specific hair follicle stem cells and abnormal immune responses, with gene regulator PPAR-y and lipid metabolism disorders playing significant roles.
January 2014 in “Revista del Centro Dermatológico Pascua” Cutaneous lupus can cause permanent hair loss by damaging hair follicles.
September 2018 in “Journal of the American Academy of Dermatology” Elderly patients with CCCA were all African American with low vitamin D, but no iron or zinc deficiencies, and no hormonal imbalances compared to younger patients.
1 citations
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July 2012 in “Springer eBooks” The document concludes that more research is needed to better understand and treat scarring hair loss conditions.
January 2026 in “Frontiers in Medicine” FFA and FAPD might be related or stages of the same disease.
73 citations
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April 2010 in “Anais Brasileiros de Dermatologia” Dermoscopy helps diagnose and monitor treatment for hair loss from scarring conditions like discoid lupus and lichen planopilaris.
73 citations
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November 2005 in “Journal of Investigative Dermatology Symposium Proceedings” Some women with common hair loss may develop permanent hair loss.
72 citations
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July 2008 in “Dermatologic Therapy” CCCA is a scarring hair loss condition mainly in African descent women, possibly caused by genetics and hairstyling, treated with gentle hair care and medications.
44 citations
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September 2012 in “Archives of Dermatology” Hair breakage may be an early sign of a hair loss condition called CCCA in African American women.
27 citations
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September 2008 in “British Journal of Dermatology” Traction may not be the only cause of cicatricial marginal alopecia.
25 citations
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September 2014 in “Dermatologic Surgery” Hair transplants can effectively treat hair loss from CCCA in African American women if there's no inflammation.
7 citations
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May 2005 in “Experimental Dermatology” Two mouse mutations cause similar hair loss despite different skin changes.
4 citations
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January 2021 in “Postępy Dermatologii i Alergologii” Hydroxychloroquine can help treat certain types of hair loss.
4 citations
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August 2010 in “Journal of the American Academy of Dermatology” Cicatricial alopecia involves scarring hair loss and can be treated with various medications.
3 citations
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January 2010 in “Journal of The European Academy of Dermatology and Venereology” Many people diagnosed with androgenic alopecia might actually have hidden scarring or inflammation.
2 citations
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April 2022 in “Clinical, cosmetic and investigational dermatology” A new plant-based treatment was effective for hair regrowth in women with a specific type of hair loss that didn't respond to usual treatments.
2 citations
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January 2013 in “Hair therapy & transplantation” Hair transplants can be a treatment for scarring hair loss if there's good blood flow and no active disease.
1 citations
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July 2014 in “Our Dermatology Online” The patient with both scarring and non-scarring hair loss showed complex immune reactions and improved with steroid treatment.
September 2025 in “Cureus” There is no standard treatment for CCCA, and practices vary widely.
December 2024 in “Texila international journal of public health” Trichoscopy effectively diagnoses and monitors cicatricial alopecias, reducing the need for biopsies.
June 2024 in “British Journal of Dermatology” Black women with CCCA are more likely to have uterine fibroids.
February 2024 in “International journal of medical science and clinical research studies” CCCA is a scarring hair disorder mainly affecting people of African descent, needing better awareness and treatment.
September 2023 in “Cosmoderma” Early diagnosis and treatment of favus can prevent permanent hair loss.
September 2022 in “Skin appendage disorders” Seborrheic dermatitis may contribute to the development of central centrifugal cicatricial alopecia.
June 2022 in “Al-Azhar International Medical Journal /Al-Azhar International Medical Journal” Adding nano fat to hair transplants improves results for scar-related hair loss.
June 2007 in “Journal of Investigative Dermatology” Title change to "Central Centrifugal Cicatricial Alopecia (CCCA)"; common in African American women; hair-grooming methods may contribute; no effective therapy found; trials needed.
25 citations
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September 2010 in “Journal of Cutaneous Medicine and Surgery” The study found that Central Centrifugal Cicatricial Alopecia mainly affects middle-aged African descent women, is linked to certain hair care practices and genetics, and often goes undiagnosed for years.
14 citations
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January 2011 in “Journal of Cutaneous Pathology” CK15 is not a reliable marker for stem cells in damaged hair follicles from patients with CCCA.
37 citations
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August 2016 in “Clinical, Cosmetic and Investigational Dermatology” The document concludes that better treatments for CCCA are needed and more research is required to understand its causes related to hairstyling and genetics.
29 citations
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January 2016 in “International Journal of Dermatology” Longer hair loss leads to more severe CCCA; early treatment and avoiding damaging hairstyles help regrowth.