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GlossaryInflammatory Mediators

substances released to initiate and regulate inflammation

Inflammatory mediators are substances released by immune cells and other tissues in response to injury or infection, which help to initiate and regulate the inflammatory response. These can include cytokines, prostaglandins, and histamines, among others, and they play crucial roles in signaling pathways that lead to symptoms like redness, swelling, and pain. Understanding these mediators is essential for developing treatments for conditions like alopecia, where inflammation can contribute to hair loss.

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research Activation of TRPV3 Inhibits Lipogenesis and Stimulates Production of Inflammatory Mediators in Human Sebocytes—A Putative Contributor to Dry Skin Dermatoses

26 citations , August 2018 in “Journal of Investigative Dermatology”

Activating TRPV3 reduces skin oil production and increases inflammation, potentially causing dry skin issues.

research Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers

31 citations , December 2023 in “Middle East Fertility Society Journal”

PCOS is linked to inflammation, and certain markers could help in its treatment.

research Cardamonin inhibits the expression of inflammatory mediators in TNF-α-stimulated human periodontal ligament cells

3 citations , June 2024 in “Immunopharmacology and Immunotoxicology”

Cardamonin reduces inflammation in gum tissue cells.

research 0041 Comparative multi-omics highlights inflammatory monocyte-derived dendritic cells as key mediators of UVB-induced photosensitivity

July 2025 in “Journal of Investigative Dermatology”

Monocyte-derived dendritic cells play a key role in UVB-induced skin sensitivity and inflammation.

research 878 Influence of bovine milk oligosaccharides on sebocyte lipid content and inflammatory mediators

April 2017 in “Journal of Investigative Dermatology”

Cow milk sugars increase fat production and inflammation in skin oil cells.

research The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Mediates the Inflammatory Process in Deep Dermal Burn Injury.

1 citations , December 2023 in “PubMed”

Combining PRP and SVF speeds up burn healing by controlling inflammation.

Androgenetic Alopecia in Polycystic Ovary Syndrome: A Cutaneous Marker of Systemic Metabo-Inflammatory and Endocrine Dysfunction: A Narrative Review

research Androgenetic Alopecia in Polycystic Ovary Syndrome: A Cutaneous Marker of Systemic Metabo-inflammatory and Endocrine Dysfunction: A Narrative Review

May 2026 in “Endocrine Connections”

Androgenetic alopecia in PCOS is linked to insulin resistance, inflammation, and genetics, not just hormones.

Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

research 705 Particulate matter induces inflammatory response in human outer root sheath cells via oxidative stress-dependent MAPK and JAK-STAT signaling pathways

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Particulate matter causes inflammation in hair cells, potentially harming hair growth.

research Phospholipase A₂ inhibition as potential therapy for inflammatory skin diseases

13 citations , April 2013 in “Immunotherapy”

Inhibiting PLA2 enzymes may help treat inflammatory skin diseases like psoriasis and dermatitis.

research Fatty acids and related lipid mediators in the regulation of cutaneous inflammation

28 citations , January 2018 in “Biochemical Society Transactions”

Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.

research Mediators of Inflammation in Polycystic Ovary Syndrome in Relation to Adiposity

102 citations , January 2010 in “Mediators of Inflammation”

PCOS is linked to obesity and inflammation, increasing cardiovascular risk.

Fisetin Promotes Differentiation, Inhibits Proliferative and Inflammatory Responses in Cultured Human Cells and Alleviates Psoriasiform Dermatitis in Mice

research 713 Fisetin promotes differentiation, inhibits proliferative and inflammatory responses in cultured human cells and alleviates psoriasiform dermatitis in mice

April 2017 in “Journal of Investigative Dermatology”

Fisetin may help treat psoriasis and reduce skin inflammation.

research 415 Targeting inflammation and specialized pro-resolving mediators to reinforce barrier function and scalp homeostasis.

November 2022 in “Journal of Investigative Dermatology”

Targeting inflammation can improve scalp and hair health.

Dual Deficiency of Melatonin and Dihydrotestosterone Promotes Stromal Cell Damage and Mediates Prostatitis via the cGAS-STING Pathway in Sleep-Deprived Mice

research Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice

March 2024 in “Cell communication and signaling”

Lack of sleep in mice leads to prostatitis by reducing certain hormones and activating an inflammatory pathway, which can be temporarily fixed with normal sleep.

research New developments in our understanding of acne pathogenesis and treatment

466 citations , June 2009 in “Experimental dermatology”

We now understand more about what causes acne and this could lead to better, more personalized treatments.

research Chapter 6 Fetal Skin Wound Healing

89 citations , January 2009 in “Advances in Clinical Chemistry”

Fetal skin heals without scarring due to unique cells and processes not present in adult skin healing.

research ACNE

58 citations , January 1997 in “Dermatologic Clinics”

Acne significantly affects mental health and quality of life, with research suggesting hormonal and genetic factors in its development and emphasizing early treatment to prevent scarring.

research The skinny on slug

53 citations , August 2010 in “Molecular Carcinogenesis”

Slug is crucial for skin health, hair growth, and healing.

research Cutaneous immunopathology of androgenetic alopecia.

10 citations , August 1991 in “PubMed”

Inflammation, possibly triggered by a specific bacteria and activated by UV radiation, may contribute to male pattern baldness.

Investigation of the Development of Hypersensitivity and Hyperalgesia After Repeated Application of Platelet-Rich Plasma in Rats: An Experimental Study

research Investigation of the Development of Hypersensitivity and Hyperalgesia After Repeated Application of Platelet-Rich Plasma in Rats: An Experimental Study

7 citations , April 2019 in “Aesthetic Surgery Journal”

Repeated use of platelet-rich plasma in rats caused increased pain sensitivity.

research Use of fluorescent light energy for the management of bacterial skin infection associated with canine calcinosis cutis lesions

5 citations , October 2020 in “Veterinary record case reports”

Fluorescent light energy may help treat skin infections in dogs with calcinosis cutis.

research Microneedling: A means of collagen induction therapy

4 citations , July 2021 in “Journal of dermatology & dermatologic surgery”

Microneedling is a simple, affordable treatment that helps with scars, wrinkles, stretch marks, and hair growth by boosting collagen.

research Immunological and Metabolic Causes of Infertility in Polycystic Ovary Syndrome

3 citations , May 2023 in “Biomedicines”

PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.

research Hair whitening in a patient with psoriasis on adalimumab reversed after switching to ixekizumab

3 citations , March 2021 in “JAAD case reports”

Switching from adalimumab to ixekizumab improved a patient's psoriasis and reversed hair whitening.

research Abstract 18: Targeted epidermal ablation of EGFR causes local and systemic inflammation

2 citations , April 2010 in “Cancer Research”

Removing EGFR in skin causes inflammation and abnormal hair growth.

research Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model

2 citations , February 2022 in “Preprints.org”

Fermented red ginseng marc may help treat atopic dermatitis by reducing inflammation and improving skin health.

research Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis

1 citations , March 2024 in “International journal of molecular sciences”

Radiation therapy damages skin structure and immune function, causing inflammation and potential hair loss.

research Vascular Proliferation in Biopsies from Active Lichen Planopilaris as a Novel Pathologic Finding

April 2026 in “American Journal of Dermatopathology”

Increased blood vessel growth in lichen planopilaris may signal active disease needing aggressive treatment.

research The Gut-Scalp Axis: A Systematic Review of Dietary Interventions on Microbiome Dysbiosis in Scalp Disorders

November 2025 in “Journal of Pioneering Medical Science”

Dietary interventions improved hair density and reduced dandruff by balancing scalp microbiota and reducing inflammation.

research LB1034 Meta-analysis of scalp transcriptome defines alopecia areata subtypes and molecular response to four (4) treatments with jak inhibiting properties

July 2024 in “Journal of Investigative Dermatology”

JAK inhibitors improve hair growth in alopecia areata, especially in patchy types.