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GlossaryInflammatory Cells

immune cells activated to fight infection or injury

Inflammatory cells are a type of immune cell that are activated in response to injury or infection. They include various cell types such as neutrophils, macrophages, and lymphocytes, which work together to eliminate pathogens, clear damaged tissue, and initiate the healing process. These cells release signaling molecules called cytokines that help coordinate the body's defense mechanisms.

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Diffuse Alopecia Areata Is Associated With Intense Inflammatory Infiltration and CD8+ T Cells in Hair Loss Regions and an Increase in Serum IgE Level

research Diffuse alopecia areata is associated with intense inflammatory infiltration and CD8+ T cells in hair loss regions and an increase in serum IgE level

24 citations , January 2012 in “Indian Journal of Dermatology, Venereology and Leprology”

Diffuse alopecia areata involves more inflammation and higher allergy-related antibodies than patchy types.

research Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases

6 citations , January 2023 in “International journal of molecular sciences”

Mast cells and CD8 T cells interact closely in skin diseases, affecting each other's behavior and contributing to conditions like psoriasis and eczema.

research Pro-inflammatory Vδ1+T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles

23 citations , September 2020 in “Journal of Dermatological Science”

Targeting Vδ1+T-cells may help treat alopecia areata.

research Inflammatory priming enhances mesenchymal stromal cell secretome potential as a clinical product for regenerative medicine approaches through secreted factors and EV-miRNAs: the example of joint disease

118 citations , April 2020 in “Stem Cell Research & Therapy”

IFNγ-primed MSC secretomes can improve joint health by reducing inflammation and supporting tissue repair.

research New insights into inflammatory memory of epidermal stem cells

2 citations , May 2023 in “Frontiers in immunology”

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

Inflammatory Implications In Female Pattern Hair Loss: Unraveling B Cell-Related Immune Activation Through Comparative Transcriptome Profiling

research 0037 Inflammatory implications in female pattern hair loss: unraveling B cell-related immune activation through comparative transcriptome profiling

July 2025 in “Journal of Investigative Dermatology”

Immune system changes may contribute to female pattern hair loss.

Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

research Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment

278 citations , March 2013 in “Gut”

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

research miR‐200a‐3p in Human Umbilical Cord Mesenchymal Stem Cell‐Derived Exosomes Attenuates UVB‐Induced Skin Inflammatory Response and Oxidative Stress via Keap1‐Nrf2 Pathway

January 2025 in “Stem Cells International”

Exosomes from stem cells can reduce UV-induced skin damage by lowering inflammation and oxidative stress.

Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

research 705 Particulate matter induces inflammatory response in human outer root sheath cells via oxidative stress-dependent MAPK and JAK-STAT signaling pathways

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Particulate matter causes inflammation in hair cells, potentially harming hair growth.

research Oral syphilis: report of three cases and characterization of the inflammatory cells

32 citations , January 2015 in “Annals of diagnostic pathology”

The document concludes that recognizing oral lesions is important for diagnosing syphilis.

research Inflammatory auxo-action in the stem cell division theory of cancer

2 citations , June 2023 in “PeerJ”

Chronic inflammation can cause cancer by making stem cells divide and mutate.

research 0041 Comparative multi-omics highlights inflammatory monocyte-derived dendritic cells as key mediators of UVB-induced photosensitivity

July 2025 in “Journal of Investigative Dermatology”

Monocyte-derived dendritic cells play a key role in UVB-induced skin sensitivity and inflammation.

Extracellular Vesicles Released by Hair Follicle and Adipose Mesenchymal Stromal Cells Induce Comparable Neuroprotective and Anti-Inflammatory Effects in Primary Neuronal and Microglial Cultures

research Extracellular vesicles released by hair follicle and adipose mesenchymal stromal cells induce comparable neuroprotective and anti-inflammatory effects in primary neuronal and microglial cultures

May 2023 in “Cytotherapy”

Hair follicle and adipose cell vesicles both protect neurons and reduce inflammation similarly.

A Novel Cell-Penetrating Peptide Supports Hair Follicle Growth Through Anti-Inflammatory and Growth Factor-Associated Mechanisms in Preclinical Models

research A novel cell-penetrating peptide supports hair follicle growth through anti-inflammatory and growth factor–associated mechanisms in preclinical models

April 2026 in “BMC Biotechnology”

A new peptide, DualPep-ALO, may help hair growth by reducing inflammation and boosting growth factors.

research Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease

60 citations , September 2023 in “Science”

BTNL proteins help control inflammatory bowel disease by maintaining specific immune cells.

research The suitability of mesenchymal stem cells for treating immune-mediated inflammatory skin diseases: a systematic review

July 2025 in “Dermatology Reports”

Mesenchymal stem cell therapy shows promise for treating certain inflammatory skin diseases, but more research is needed.

research The Identification of Bipotent Dermal Stem Cells and The Role of Anti-Inflammatory Macrophages During Hair Follicle Regeneration

January 2016

Bipotent dermal stem cells and specific macrophages are crucial for hair regrowth and regeneration.

Fisetin Promotes Differentiation, Inhibits Proliferative and Inflammatory Responses in Cultured Human Cells and Alleviates Psoriasiform Dermatitis in Mice

research 713 Fisetin promotes differentiation, inhibits proliferative and inflammatory responses in cultured human cells and alleviates psoriasiform dermatitis in mice

April 2017 in “Journal of Investigative Dermatology”

Fisetin may help treat psoriasis and reduce skin inflammation.

research CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment

28 citations , April 2024 in “Immunity”

CD80 on skin stem cells helps expand Treg cells to aid wound healing.

research T Cells Promote Distinct Transcriptional Programs of Cutaneous Inflammatory Disease in Keratinocytes and Dermal Fibroblasts

2 citations , April 2025 in “Journal of Investigative Dermatology”

Anti-Inflammatory Effects in LPS-Treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-San

research Anti-inflammatory Effects in LPS-treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-san

December 2021 in “Daehanhanuihakoeji”

The traditional herbal formulas Yongdamsagan-Tang and Paljung-san, along with the drug finasteride, can reduce inflammation and may work together without affecting each other's effectiveness against benign prostatic hyperplasia.

research Immunohistochemical analysis of T-cell subsets in the inflammatory infiltrates of alopecia areata and its comparison with androgenetic alopecia

April 2020 in “International Journal of Dermatology”

T-cell patterns in skin help distinguish alopecia areata from androgenetic alopecia.

research SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata

13 citations , May 2023 in “Journal of Dermatological Science”

Reduced SIRT1 in hair cells may cause alopecia areata by triggering immune responses.

research The Effectiveness of Adipose Tissue-Derived Mesenchymal Stem Cells Mixed with Platelet-Rich Plasma in the Healing of Inflammatory Bowel Anastomoses: A Pre-Clinical Study in Rats

2 citations , January 2024 in “Journal of Personalized Medicine”

Combining stem cells with platelet-rich plasma improves bowel healing in rats.

research Influence of Immune Cells and Circulating Inflammatory Cytokines on Pathological Scars: A Mendelian Randomization Study

July 2025 in “Clinical Cosmetic and Investigational Dermatology”

Immune cells and cytokines significantly affect pathological scar development.

research Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: a longitudinal imaging study

87 citations , June 2010 in “Stem Cell Research & Therapy”

Stem cells can move to brain injury sites and be tracked, showing promise for treating brain diseases.

research Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model

3 citations , September 2024 in “Journal of Microbiology and Biotechnology”

Human placenta extract reduces inflammation and symptoms in atopic dermatitis.

research Single-cell analysis of basal cell carcinoma reveals heat shock proteins promote tumor growth in response to WNT5A-mediated inflammatory signals

1 citations , October 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Heat shock proteins help basal cell carcinoma grow by responding to inflammation signals.

research Cell adhesion molecules in inflammatory and neoplastic skin diseases

7 citations , May 1993 in “Journal of the European Academy of Dermatology and Venereology”

Cell adhesion molecules are important in the development of certain skin diseases.

Towards a Consensus Potency Assay for Mesenchymal Stromal Cells: A Matrix Analysis of Cell Source, Donor Variability, and Inflammatory Stimuli to Refine Surrogate Markers of Immunomodulation

research Towards a consensus potency assay for mesenchymal stromal cells: a matrix analysis of cell source, donor variability and inflammatory stimuli to refine surrogate markers of immunomodulation

3 citations , May 2019 in “Cytotherapy”

ATIR101 improves survival in stem cell transplant patients; Australian stem cell treatment decisions are influenced by regulation changes.