Search

for
Search:

GlossaryInnate Immune Cells

cells that provide immediate, non-specific defense against pathogens

Innate immune cells are a type of immune cell that form the body's first line of defense against infections. These cells, which include macrophages, neutrophils, and natural killer (NK) cells, respond quickly to pathogens in a non-specific manner, meaning they attack any foreign invader without needing prior exposure. They are crucial for immediate defense and also help to activate the adaptive immune system for a more targeted response.

Related Terms

Sort by

Research

30 / 1000+ results

research Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

47 citations , March 2019 in “Journal of immunology research”

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

research Hidradenitis suppurativa: A folliculotropic disease of innate immune barrier dysfunction?

9 citations , August 2021 in “Experimental dermatology”

Hidradenitis suppurativa is a skin disease caused by the breakdown of the skin's natural immune barriers, especially around hair follicles.

research Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models

5 citations , February 2022 in “International Journal of Molecular Sciences”

Different immune cells like platelets, mast cells, neutrophils, macrophages, T cells, B cells, and innate lymphoid cells all play roles in skin wound healing, but more research is needed due to inconsistent results and the complex nature of the immune response.

research Squaric Acid Dibutylester Promotes Innate Immune-Driven Hair Growth with CD206+ Macrophage Accumulation in the Dermis

September 2025 in “JID Innovations”

Squaric acid dibutylester promotes hair growth by activating immune cells, especially macrophages.

research 440 Squaric acid dibutylester, used in alopecia areata immunotherapy, promotes innate immune-driven hair growth with CD206+ macrophage accumulation in the dermis

July 2024 in “Journal of Investigative Dermatology”

Squaric acid dibutylester helps hair growth by increasing certain immune cells in the skin.

research A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Immune cells are essential for early hair and skin development and healing.

research Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium

181 citations , January 2019 in “Cell”

Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.

research Innate lymphoid cells type 1 may be new, non-antigen-specific player in the pathogenesis of alopecia areata

August 2019

Innate lymphoid cells type 1 may contribute to alopecia areata by damaging hair follicles.

research 431 Innate lymphoid cells type 1 may be new, non-antigen-specific player in the pathogenesis of alopecia areata

September 2019 in “Journal of Investigative Dermatology”

Innate lymphoid cells type 1 may contribute to alopecia areata.

Multi-Modal Skin Atlas Identifies a Multicellular Immune-Stromal Community Associated with Disrupted Cornification and Specific T Cell Expansion in Atopic Dermatitis

research Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis

February 2026 in “Nature Communications”

A specific group of immune and skin cells may cause chronic inflammation in atopic dermatitis.

research Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair

86 citations , April 2016 in “Nature Communications”

Notch1 helps skin heal by attracting specific immune cells.

research Dissecting the Roles of Innate Cells in the Skin and Intractable Skin Diseases

1 citations , January 2022 in “The Keio Journal of Medicine”

Hair follicles regulate immune cells in the skin, and disrupting certain pathways can lead to skin issues and infections.

Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

research Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

22 citations , June 2012 in “PLOS ONE”

Cholesterol-related compounds can stop hair growth and cause inflammation in a type of scarring hair loss.

research Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection

February 2024 in “International journal of molecular sciences”

Type 3 Innate Lymphoid Cells help maintain skin health and balance, and are involved in skin diseases and healing.

research Jagged-1+ Skin Tregs Modulate the Innate Immune Response to Wound Healing

June 2024 in “Research Square (Research Square)”

Jagged-1 in skin Tregs is crucial for timely wound healing by recruiting specific immune cells.

research New insights into inflammatory memory of epidermal stem cells

2 citations , May 2023 in “Frontiers in immunology”

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

research Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia

March 2023 in “Research Square (Research Square)”

Immune changes and specific genes contribute to male hair loss.

research Resident Memory T Cells in Autoimmune Skin Diseases

50 citations , May 2021 in “Frontiers in immunology”

Certain immune cells contribute to skin autoimmune diseases, and some treatments can reverse hair loss in these conditions.

research Pro-inflammatory Vδ1+T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles

23 citations , September 2020 in “Journal of Dermatological Science”

Targeting Vδ1+T-cells may help treat alopecia areata.

research Urticaria Neonatorum: Accumulation of tryptase‐expressing mast cells in the skin lesions of newborns with Erythema Toxicum

14 citations , December 2007 in “Pediatric allergy and immunology”

Newborns with the common rash Erythema Toxicum have many active mast cells in their skin, but these cells don't produce the LL-37 peptide.

Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity: Lessons from Alopecia Areata

research Genes and Immune Response in Alopecia Areata: Review of the Alopecia Areata Research Summit First Day Proceedings

6 citations , December 2013 in “Journal of Investigative Dermatology Symposium Proceedings”

Alopecia areata involves complex immune and genetic factors, with potential treatment targets identified, but more research is needed.