research Decision letter: Plant Trans-Golgi Network/Early Endosome pH regulation requires Cation Chloride Cotransporter (CCC1)
CCC1 is essential for ion balance and proper plant cell function.
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research Enhancing the diagnostic yield of monogenic diabetes in unresolved cases with early-onset hyperglycemia
Combining genetic and physical data improves diagnosis and treatment for early-onset monogenic diabetes.
research Update on the combination of myo-inositol/d-chiro-inositol for the treatment of polycystic ovary syndrome
Myo-inositol and D-chiro-inositol, especially in a 40:1 ratio, effectively treat PCOS by improving insulin sensitivity and ovulation.
research TCM “medicine and food homology” in the management of post-COVID disorders
Traditional Chinese medicinal foods may help manage long-term post-COVID symptoms.
research In Silico Promoter Motif Analysis of Human Fertility-Related Genes
The study found potential new DNA patterns in fertility genes, but further testing is needed.
research Special collection on inward rectifying K+ channels
Inward rectifier potassium channels are important in many body functions and diseases, and could be potential drug targets.
research Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated Derivatives
A new method efficiently modifies alkenes to create useful medicinal compounds.
research Light scattering from human hair fibers
Researchers developed a new model for more realistic computer graphics of hair by considering how light scatters on hair fibers.
research HtrA1L364P leads to cognitive dysfunction and vascular destruction through TGF‐β/Smad signaling pathway in CARASIL model mice
The HtrA1L364P mutation causes brain dysfunction and blood vessel damage.
research Sex-Chromosome-Related Dimorphism in Steroidogenic Enzymes and Androgen Receptor in Response to Testosterone Treatment: An In Vitro Study on Human Primary Skeletal Muscle Cells
Chromosomal differences affect how muscle cells respond to testosterone.
research American College of Clinical Pharmacology Twenty‐Second Annual Meeting November 1–3, 1993 Boston, Massachusetts
research pMB FLASH - Status and Perspectives of Combining Proton Minibeam with FLASH Radiotherapy
Combining Proton Minibeam with FLASH Radiotherapy may improve cancer treatment by reducing side effects and increasing effectiveness.
research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids
The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.
research Immune-Epithelial Cross Talk in Regeneration and Repair
Immune-epithelial interactions are crucial for tissue repair, but unchecked can cause diseases.
research Author response: Plant Trans-Golgi Network/Early Endosome pH regulation requires Cation Chloride Cotransporter (CCC1)
CCC1 is essential for pH balance and normal cell function in plants.
research Memory Encoded Throughout Our Bodies: Molecular and Cellular Basis of Tissue Regeneration
research MEGA PROTAC, MEGA DOCK-based PROTAC mediated ternary complex formation pipeline with sequential filtering and rank aggregation
MEGA PROTAC improves prediction and ranking of protein complexes better than existing methods.
research G4, is a new transgenic mouse model for the polycystic ovaries syndrome
Researchers created a new mouse model, G4, that mimics human PCOS symptoms and links the condition to a specific gene.
research Module-based complexity formation: periodic patterning in feathers and hairs
The conclusion is that understanding how feathers and hairs pattern can help in developing hair regeneration treatments.
research Commentaries on Micro/Minigrafting vs Follicular Unit Transplantation: An Assessment of the Recent Bernstein/Rassman Article, “Follicular Unit Graft Yield Using Three Different Techniques”
The conclusion compares the effectiveness of different hair transplant techniques.
research Cytoplasmic Ca2+ concentrations in intact Merkel cells of an isolated, functioning rat sinus hair preparation
research Whole Neonatal Cochlear Explants as an In vitro Model
The new method makes it easier to study the whole cochlea from newborn mice and rats in the lab.
research Thrombocytosis Associated with Low-Molecular-Weight Heparin
International medical graduates outperformed U.S. graduates on an internal medicine exam.
research Mathematical model for alopecia areata
The model showed that immune system guardians and the cytokine interferon-γ are key in alopecia areata progression.
research Contract cheating websites in Spain (2019–2024): web traffic trends during COVID-19 and the rise of generative AI
Contract cheating website traffic in Spain surged during COVID-19 but declined with the rise of AI tools.
research Further errors in polymorph identification: furosemide and finasteride
Errors found in identifying furosemide and finasteride polymorphs due to incomplete data.
research Preparing regenerative therapies for clinical application: proposals for responsible translation
The document suggests a need for collaboration, better evidence, and a responsible framework to safely and effectively advance regenerative therapies to clinical use.
research A Temporal Mathematical Model of Alopecia Areata: Investigating Hair Cycle Dynamics and Disease Progression
The model helps understand alopecia areata and suggests ways to improve treatment by targeting immune issues.
research Development of a novel, clinically-relevant model for investigating factors that stimulate human hair growth
Testosterone stimulates growth in intermediate hair follicles, but this can be blocked by cyproterone acetate.
research From Reproductive Disorder to Metabolic Syndrome: The Evolution of Polycystic Ovary Syndrome (PCOS) into Polyendocrine Metabolic Ovarian Syndrome (PMOS)
PCOS is now seen as a complex metabolic and hormonal disorder called PMOS.