855 citations
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June 2009 in “The Journal of Clinical Endocrinology & Metabolism” The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.
22 citations
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May 2006 in “Experimental and Clinical Endocrinology & Diabetes” Calculated testosterone values are reliable for assessing hyperandrogenemia in women, making direct measurement unnecessary.
1 citations
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July 2015 in “AACE clinical case reports” Removing both ovaries treated the woman's excess male hormone symptoms.
38 citations
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May 1971 in “Clinical genetics” A specific metabolite, not a receptor protein, triggers the production of certain kidney enzymes, but this process is disrupted in mice with a mutation causing testicular feminization.
The 0.05% dutasteride topical solution effectively promotes hair growth with fewer side effects than oral treatments.
January 2005 in “Fuzhou daxue xuebao. Ziran kexue ban” The method is quick and effective for testing steroid 5 alpha-reductase inhibitors.
13 citations
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January 2019 in “Endocrine journal” Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.
September 2024 in “Indian Journal of Dermatology Venereology and Leprology” Mesotherapy with bicalutamide has limited effectiveness for female hair loss.
November 2024 in “Pharmaceutics” Transfersomes are better than liposomes for targeting hair follicles in alopecia treatment.
Finasteride and testosterone are the drugs most linked to male infertility, but many other potential drugs may be under-reported.
19 citations
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July 2019 in “Journal of Endocrinology” GTx-024 and Danazol affect the uterus like DHT, while GTx-007 has little impact.
3 citations
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July 2009 in “Experimental and Clinical Endocrinology & Diabetes” Low-dose Buserelin effectively reduces hirsutism with minimal side effects.
October 2025 in “Transplantation” Dissolving microneedles can effectively deliver dutasteride for hair loss treatment.
19 citations
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December 2021 in “Endocrine Reviews” There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.
32 citations
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May 1987 in “The Journal of Clinical Endocrinology & Metabolism” Salivary testosterone is a better measure for hirsutism than serum testosterone.
Bilateral Orchiectomy effectively reduces the need for anti-androgen medication in most transgender females.
January 2025 in “The World Journal of Men s Health” Intratesticular PRP injections are safe but not proven to improve sperm retrieval in certain infertile men.
21 citations
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November 2010 in “Talanta” Researchers developed a reliable method to measure testosterone and epitestosterone in urine for medical and anti-doping use.
April 2026 in “BMJ Case Reports” Leydig cell tumors can cause high testosterone in women and are treated by removing the ovaries.
5 citations
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December 2004 in “Dermatology” Two women with very high androgen levels had only slight skin issues, one due to a non-classical adrenal disorder and the other due to an adrenal tumor.
October 2006 in “Urology” Combination therapy with Finasteride is more effective than alpha-blocker alone for BPH symptoms in small prostate volume.
1 citations
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May 2018 in “Clinical chemistry” The girl's unexpected pubic hair growth led to a diagnosis different from complete androgen insensitivity syndrome.
1 citations
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October 2020 in “Current Drug Discovery Technologies” The research found that compound 6, a newly created steroid, is more effective at inhibiting 5α-reductase (an enzyme) than current treatments, suggesting it could be a better option for treating urinary tract symptoms in men.
January 2008 in “대한피부과학회지” Androgenetic alopecia is more common in men, linked to genetics and androgen levels, but routine pelvic ultrasound isn't recommended.
The case showed the need for quick investigation of virilization in women and how emotional health is linked to physical health.
1 citations
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June 2007 in “Journal of Clinical Oncology” Weekly bicalutamide is safe and effective, with 50 mg/week recommended.
October 2021 in “European urology open science”
January 1977 in “Case Reports in Medicine” Steroid cell tumors in the ovary are rare, can produce testosterone causing symptoms, and are mainly treated with surgery.
111 citations
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May 2001 in “Human reproduction update” Insufficient androgen action in male fetuses can cause genital development issues due to genetic mutations or environmental chemicals.
39 citations
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October 2018 in “Aesthetic surgery journal” Injectables can feminize or masculinize a transgender person's face, but more research is needed for best practices.