research 575 INTASYL self-delivering RNAi: A flexible platform to treat dermatological malignancies
INTASYL is a promising, adaptable RNAi technology for treating skin cancers.
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570-600 / 1000+ resultsresearch Impact of formulation design and lyophilisation on the physicochemical characteristics of finasteride nanosystems
The finasteride nanosystem with trehalose is stable and effective for topical hair loss treatment.
research Localized corticosteroid delivery in alopecia areata using microneedle patch technology
research Effectiveness of Low-dose Ethinylestradiol/Cyproterone Acetate and Ethinylestradiol/Desogestrel with and without Metformin on Hirsutism in Polycystic Ovary Syndrome: A Randomized, Double-blind, Triple-dummy Study.
Both oral contraceptives reduced hirsutism in PCOS patients, but adding metformin showed no extra benefit.
research Evaluation of glucuronide metabolite stability in dried blood spots
Dried blood spots can be as stable as frozen liquid samples for storing certain metabolites.
research Alopecia Areata Developing in Non-Insulin Dependent Diabetes Mellitus Type-2, an Autoimmune Disease
A woman with type 2 diabetes developed alopecia areata, suggesting a link between the two autoimmune conditions.
research Dermatological adverse reactions and therapeutic potential of semaglutide, liraglutide and tirzepatide: Analysis of UK pharmacovigilance data and literature review
GLP-1 receptor agonists can help skin conditions but may cause hair loss and other skin issues.
research Ivarmacitinib stimulates hair regrowth in severe alopecia areata
A phase 3 trial involving 330 adults with severe alopecia areata demonstrated that ivarmacitinib, a selective JAK1 inhibitor, significantly improved hair regrowth with a favorable safety profile. At week 24, 34.9% of participants in the 4 mg group and 40.6% in the 8 mg group achieved a SALT score of 20 or less, indicating at least 80% scalp hair coverage, compared to 9% in the placebo group. The treatment effect was statistically significant, with a 25.6% improvement for the 4 mg dose and 31.6% for the 8 mg dose over placebo. By week 52, those initially on placebo who switched to ivarmacitinib showed further improvement, with 47% in the 4 mg group and 63% in the 8 mg group achieving SALT20. The safety profile was consistent across groups, with no new safety concerns reported. These findings suggest ivarmacitinib as a promising and well-tolerated treatment option for severe alopecia areata.
research Comparison of spironolactone and spironolactone plus metformin in the treatment of polycystic ovary syndrome
Both treatments reduced excessive hair growth in PCOS, but there was no difference in weight, hair score, hormone levels, or insulin resistance.
research 856 Topical application of newly developed pseudoceramide improved both skin and hair barrier functions
Applying pseudoceramide improved skin and hair health.
research Dissolving microneedle array patches containing mesoporous silica nanoparticles of different pore sizes as a tunable sustained release platform
Dissolving microneedle patches can effectively deliver drugs over time.
research Incorporation of Finasteride-Loaded Microspheres into Personalized Microneedle for Sustained Transdermal Delivery
The new microneedle system safely delivers finasteride through the skin to treat hair loss.
research Study on Human Bioequivalency of Two Preparations of Finasteride
The two finasteride preparations are bioequivalent.
research Low serum biotin in Japanese children fed with hydrolysate formula
Japanese infants fed hydrolysate formula may have low biotin levels.
research 17-Hydroxyprogesterone Responses to Gonadotropin-Releasing Hormone Disclose Distinct Phenotypes of Functional Ovarian Hyperandrogenism and Polycystic Ovary Syndrome
The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.
research Effect of a transcriptional inactive or absent vitamin D receptor on beta-cell function and glucose homeostasis in mice
Mice without active or present vitamin D receptors maintain normal blood sugar control and islet gene expression when calcium levels are normal.
research Safety and Efficacy of Mesotherapy with Placenta Polypeptide Injection for Moderate-to-Severe Sensitive Skin: A Multicenter, Randomized, Controlled Trial
Placenta polypeptide injection is a safe and effective treatment for sensitive skin.
research Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome.
Metformin and rosiglitazone both improved insulin use and hormonal symptoms in women with PCOS.
research Semaglutide Treatment of Excessive Body Weight in Obese PCOS Patients Unresponsive to Lifestyle Programs
Semaglutide helps obese PCOS patients lose weight and improve health.
research 755 Repurposing of DPP4 inhibition to improve hair follicle activation and regeneration
Blocking DPP4 can help activate hair growth and improve hair regeneration.
research Assessment of the Relationship Between Serum High Molecular Weight Adiponectin Hormone Levels and Insulin Resistance in Patients with Polycystic Ovary Syndrome
Women with PCOS have lower adiponectin hormone levels and are more likely to have insulin resistance.
research Bioequivalence Study of Two Different Coated Tablet Formulations of Finasteride in Healthy Volunteers
Two finasteride tablet types are equally effective and can be swapped.
research Treatment Options for Hirsutism: A Systematic Review and Network Meta-Analysis
Oral contraceptives and antiandrogens are effective for treating hirsutism, with antiandrogens being the most effective.
research Simultaneous determination of multi-class active pharmaceutical ingredients by UHPLC-HRMS
A new method was developed to accurately detect and measure 47 different drug ingredients in various products.
research FORMULATION AND EVALUATION OF TRIAMCINOLONE ACETONIDE SERUM WITH DERMA STAMP ASSISTED DELIVERY FOR THE MANAGEMENT OF ALOPECIA AREATA
The serum with microneedling device improves hair loss treatment effectively and safely.
research 10.51847/ubmwCM2
Emulgels are promising for delivering drugs topically due to their easy spreadability and stability.
research New Insight Into the Immunostaining Method Suitable for the Pilosebaceous Complex Unit
The study found that a one-step antibody method is better than the LSAB method for accurately studying hair follicle structures without false positives.
research Infliximab as First‐Line Therapy in Severe Pediatric Crohn Disease
Early use of infliximab in severe pediatric Crohn's disease can lead to significant improvement and remission.
research Validation of Finasteride Tablets USP by HPLC Isocratic with UV Detector
The method is effective and suitable for testing finasteride tablets.
research Evaluation of hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn.)
Tridax procumbens significantly lowers blood sugar in diabetic rats.