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The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

research The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain

70 citations , December 2004 in “Differentiation”

The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.

research Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation

10 citations , August 2023 in “The EMBO Journal”

Kdm6b is crucial for skin cell differentiation.

research A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb

5 citations , June 2008 in “British Journal of Dermatology”

research Type XVII collagen coordinates proliferation in the interfollicular epidermis

124 citations , July 2017 in “eLife”

Type XVII collagen helps control skin cell growth and could be a target for anti-aging treatments.

To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

research To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease

23 citations , April 2016 in “American Journal of Pathology”

The research suggests that a specific skin gene can be controlled by signals within and between cells and is wrongly activated in certain skin diseases.

research Regulation of Involucrin Gene Expression

138 citations , June 2004 in “Journal of Investigative Dermatology”

Involucrin gene expression is controlled by specific proteins and signaling pathways.

research Ligand‐independent Regulation of the hairless Promoter by Vitamin D Receptor^†

10 citations , February 2008 in “Photochemistry and photobiology”

Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.

research 085 Post-translational regulation of hair keratins in transfected COS-1 cells

July 1995 in “Journal of Dermatological Science”

research REV7: a small but mighty regulator of genome maintenance and cancer development

1 citations , January 2025 in “Frontiers in Oncology”

REV7 is crucial for genome stability and cancer treatment, making it a potential target for therapy.

research KRT16 wt Allele

February 2020 in “Definitions”

Mutations in the KRT16 gene can cause skin and nail disorders.

research Author response: Type XVII collagen coordinates proliferation in the interfollicular epidermis

June 2017

Type XVII collagen helps control skin cell growth and may have anti-aging effects.

research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

387 citations , November 2003 in “Journal of Investigative Dermatology”

The K15 promoter effectively targets stem cells in the hair follicle bulge.

research The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology

62 citations , December 2007 in “Journal of Cellular and Molecular Medicine”

Kremen is crucial for proper development and preventing tumors by regulating Wnt signaling.

research HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression

132 citations , February 2002 in “Journal of Biological Chemistry”

HOXC13 is crucial for regulating hair keratin genes in hair follicles.

research DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging

December 2025 in “Clinical Cosmetic and Investigational Dermatology”

ZDHHC17 methylation may help treat or identify facial skin aging.

research Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis

February 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

Keratin 15 helps keep skin cells in a young, undifferentiated state.

research Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

191 citations , September 2011 in “Cell stem cell”

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

research Transcription Regulation and Protein Subcellular Localization of the Truncated Basic Hair Keratin hHb1-ΔN in Human Breast Cancer Cells

8 citations , June 2001 in “Journal of Biological Chemistry”

A truncated protein linked to breast cancer may change cell adhesion.

research Developmental and evolutionary comparative analysis of a regulatory landscape in mouse and chicken

10 citations , June 2022 in “Development”

Gene regulation evolved differently in mouse and chicken skin, but remained stable in their trunks.

research Dissection of a Complex Enhancer Element: Maintenance of Keratinocyte Specificity but Loss of Differentiation Specificity

42 citations , June 2002 in “Molecular and Cellular Biology”

Keratinocyte gene expression is controlled by multiple modules with specific binding sites.

research Re-Assessing K15 as an Epidermal Stem Cell Marker

36 citations , March 2011 in “Stem Cell Reviews and Reports”

research Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice

2 citations , June 2023 in “Journal of cell science”

Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.

research 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification

1 citations , April 2018 in “Journal of Investigative Dermatology”

PRC1 is essential for proper skin development and stem cell formation by controlling gene activity.

research Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle

87 citations , November 2002 in “Journal of Investigative Dermatology”

research H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development

1 citations , August 2025 in “Epigenetics & Chromatin”

H3K4me3 helps control RSPO3 to influence hair growth and development.

research Mechanism of JmjC-containing protein Hairless in the regulation of vitamin D receptor function

5 citations , September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease”

Hairless protein helps control hair growth by regulating vitamin D receptor activity.

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