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The study identified the major component of the water fraction from katuk (Sauropus androgynous) leaves as an alkaloid compound with the molecular formula C21H39N6O2 and a molecular mass of 406.3131 m/z, named (S, S)-5, 5′-amino-4,4′-dihexyl-propyldihydropyrazol-3, 3′-one. This compound was not previously reported in S. androgynous. The research utilized liquid chromatography–mass spectrometry (LC-MS) and other analytical techniques to achieve this identification. The study highlighted the potential of katuk leaves in alternative treatments, particularly for hair growth, due to the presence of various phytochemicals such as alkaloids, flavonoids, tannins, and saponins. There were no conflicts of interest or financial support for this study.

This study investigates the potential of calanthoside, a compound with an indole 2-S-,3-O-bis-glucoside structure, as a hair growth stimulant. The research focuses on the role of its two glucoside moieties in promoting the proliferation of human follicle dermal papilla cells (HFDPC), which are crucial for hair growth. The findings suggest that these glucoside moieties are significant in enhancing HFDPC proliferation, indicating calanthoside's potential as a treatment for androgenetic alopecia (AGA). This study provides a foundation for further exploration of calanthoside as a novel therapeutic option for hair loss.