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GlossaryKeratin Gene Expression

process where cells produce keratin proteins for hair and skin

Keratin gene expression refers to the process by which cells produce keratin, a type of protein that is a key structural component of hair, skin, and nails. This involves the activation of specific genes within a cell's DNA that encode for keratin proteins, leading to their synthesis and assembly. Understanding keratin gene expression is crucial for studying hair growth, skin disorders, and conditions like alopecia.

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research Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter

215 citations , November 2000 in “Journal of Investigative Dermatology”

The system allows precise control of gene expression in mouse skin, useful for studying skin biology.

research A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n (K17n), Exhibits Preferred Expression in Nail Tissue

31 citations , April 2004 in “Journal of Investigative Dermatology”

A new mouse gene, Keratin 17n, is mainly found in nail tissue and may explain why mice without Keratin 17 don't have nail issues.

research The Microanatomy, Cell Replication, and Keratin Gene Expression of Hair Follicles during a Photoperiod-lnduced Growth Cycle in Sheep

20 citations , January 1995 in “Cells tissues organs”

Changing light periods synchronized wool growth cycles in sheep.

research Keratin Gene Expression Differences in Wool Follicles and Sequence Diversity of High Glycine-Tyrosine Keratin-Associated Proteins (Kaps) in Magra Sheep of India

9 citations , December 2018 in “Journal of Natural Fibers”

Magra sheep's wool luster is linked to specific keratin gene expression and protein variations.

research Keratin Gene Expression in Wool Fibre Development

5 citations , January 1988

Only two of the four keratin genes are expressed in wool fibers.

DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression

research 764 DNA dioxygenases Tet1/2/3 control hair matrix keratinocyte differentiation and hair shaft shape via regulation of hair keratin gene expression

June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.

research Analysis of Sequences Controlling Tissue-Specific and Hyperproliferation-Related Keratin 6 Gene Expression in Transgenic Mice

26 citations , February 1998 in “DNA and Cell Biology”

K6 gene expression can be controlled and manipulated in mice for studying skin disorders.

research Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation–Induced Skin Damage

3 citations , July 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Keratin 17 is important for skin's response to radiation, affecting many genes and cell division.

research Regulation of Keratin Gene Expression in Hair Follicle Differentiation^a

98 citations , December 1991 in “Annals of the New York Academy of Sciences”

Keratin gene regulation is similar across mammals, affecting hair follicle differentiation.

research Sequence of a Cashmere goat type I hair keratin gene and its expression in skin

3 citations , December 2008 in “Frontiers of Agriculture in China”

The Cashmere goat hair keratin gene is crucial for hair structure.

research A new tool for conditional gene manipulation in a subset of keratin‐expressing epithelia

4 citations , July 2012 in “Genesis”

The Megsin-Cre transgene is a new tool for genetic manipulation in the skin and upper digestive tract.

research Defining a Region of the Human Keratin 6a Gene That Confers Inducible Expression in Stratified Epithelia of Transgenic Mice

44 citations , May 1997 in “Journal of Biological Chemistry”

The human keratin 6a gene's specific sequences trigger expression in skin layers after injury.

research A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms

3 citations , March 2023 in “International journal of molecular sciences”

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

research Keratin 17 Gene Expression during the Murine Hair Cycle

70 citations , March 1997 in “Journal of Investigative Dermatology”

research Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle

46 citations , November 1998 in “Experimental Cell Research”

K15 gene is mainly active in the basal layers of hair follicles and epithelia, aiding early skin cell development.

research Study on kerantin association protein 8.1 gene expression of Liaoning cashere goats in skin and hair follicle

January 2014 in “China Feed”

Higher expression of the keratin-associated protein 8.1 gene in Liaoning cashmere goats is linked to finer cashmere fibers.

research 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

TET enzymes are important for skin and hair development by controlling gene activity in specific areas.

research Sequence, expression, and evolutionary conservation of a gene encoding a glycine/tyrosine-rich keratin-associated protein of hair.

76 citations , February 1993 in “Journal of Biological Chemistry”

KAP6 genes are conserved across species and active in hair follicles.

research Study on Differential Expression of Keratin Associated Protein 8-1 Gene of Different Varieties of Ovis aries in Skin and Hair Follicle

January 2014 in “China Animal Husbandry & Veterinary Medicine”

The KAP8-1 gene affects skin, hair follicle development, and wool quality in different sheep varieties.

research Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice

January 2026 in “MDPI (MDPI AG)”

The hairy ear mutation in mice is linked to changes in gene expression affecting hair growth.

research Genetically separable determinants of hair keratin gene expression

27 citations , January 2000 in “Developmental Dynamics”

Mutations in the Whn gene affect hair keratin gene expression differently.

research Sequence Analysis and Expression of a TypeIHair Keratin Gene in Goat Skin

January 2006

The goat hair keratin gene is very similar to sheep's and is strongly expressed in goat hair follicles.

research Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotype

75 citations , April 2000 in “Developmental Dynamics”

Whn is essential for hair growth, and its malfunction causes hair loss.

research A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice.

46 citations , May 1995 in “Proceedings of the National Academy of Sciences”

A specific gene region can control targeted and responsive gene expression in mice, useful for skin disorder treatments.

research Hair follicle differentiation: expression, structure and evolutionary conservation of the hair type II keratin intermediate filament gene family

65 citations , February 1992 in “Development”

Type II keratin genes are crucial for hair follicle differentiation and have a conserved structure and expression pattern.

research Hair-Specific Keratins: Characterization and Expression of a Mouse Type I Keratin Gene

27 citations , November 1991 in “Journal of Investigative Dermatology”

research HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression

132 citations , February 2002 in “Journal of Biological Chemistry”

HOXC13 is crucial for regulating hair keratin genes in hair follicles.

research A Splice Site Mutation in the Gene of the Human Type I Hair Keratin hHa1 Results in the Expression of a Tailless Keratin Isoform

28 citations , December 1997 in “Journal of Biological Chemistry”

A genetic mutation in the hHa1 gene creates a smaller, but still functional, hair protein without causing hair problems.

research Mapping of monilethrix to the type II keratin gene cluster at chromosome 12q13 in three new families, including one with variable expressivity

21 citations , September 1997 in “British Journal of Dermatology”

Monilethrix is linked to the type II keratin gene on chromosome 12q13.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”