49 citations
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April 2010 in “International Journal of Cosmetic Science” Hair ages as the cuticle wears down, especially beyond 1 meter from the root, affecting its strength and shine.
49 citations
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November 2013 in “The Journal of Steroid Biochemistry and Molecular Biology” Vitamin D receptor helps control skin cell growth and hair development.
48 citations
,
January 2002 in “Journal of Structural Biology” Trichocyte filaments have a low-density core and may include proteins for hair structure.
48 citations
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November 2002 in “Journal of biological chemistry/The Journal of biological chemistry” Genetic variations in hair keratin proteins exist but don't significantly affect hair structure.
48 citations
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April 2008 in “Human Molecular Genetics” Progerin affects cell shape but not hair or skin in mice.
48 citations
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April 2021 in “Pharmaceuticals” Liposomal curcumin improves skin cancer treatment effectiveness while sparing normal cells.
47 citations
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January 2017 in “RSC Advances” Keratin peptides can change hair shape gently without harsh chemicals.
47 citations
,
September 2004 in “Journal of Biological Chemistry” Hoxc13 regulates specific hair protein genes on mouse chromosome 16.
47 citations
,
January 2024 in “iScience” Stress keratins are expressed less in diseased skin and are linked to differentiation, inflammation, and immunity.
46 citations
,
December 1998 in “Journal of Biological Chemistry” Keratin 19 forms less stable and shorter filaments than keratin 14, giving unique traits to certain skin cells.
46 citations
,
November 1998 in “Experimental Cell Research” K15 gene is mainly active in the basal layers of hair follicles and epithelia, aiding early skin cell development.
45 citations
,
October 2019 in “Clinical and Experimental Dermatology” Targeted therapies promoting differentiation could help treat basal cell carcinoma by exhausting cancer stem cells.
45 citations
,
December 2007 in “The FASEB journal” There are two types of stem cells in rodent hair follicles, each with different keratin proteins.
44 citations
,
May 2008 in “Acta Zoologica” Keratinization in embryos helped vertebrates adapt to land by forming a protective skin barrier.
44 citations
,
August 1990 in “PubMed” Keratins K1 and K10 are found in the inner root sheath and cuticle of human hair follicles.
44 citations
,
March 2012 in “Molecular Carcinogenesis” Keratin 15 cells from hair follicles help develop and maintain skin tumors in mice.
44 citations
,
January 2004 in “American journal of clinical dermatology” Understanding genetic mutations helps diagnose and treat skin disorders like ichthyosis.
44 citations
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May 1997 in “Journal of Biological Chemistry” The human keratin 6a gene's specific sequences trigger expression in skin layers after injury.
43 citations
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October 2006 in “Journal of Cell Science” Keratin 10 end domains may increase skin cancer risk by reducing cell death.
42 citations
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January 2017 in “Genes” The gene KAP22-1 affects wool yield and fiber shape in sheep.
42 citations
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July 2010 in “European Journal of Cell Biology” Thyroid hormones affect hair follicle stem cells by promoting differentiation and reducing growth.
42 citations
,
October 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” Mutations in the KRT85 gene cause hair and nail problems.
42 citations
,
January 2017 in “Stem cells international” Adding hyaluronic acid helps create larger artificial hair follicles in the lab.
42 citations
,
June 2002 in “Molecular and Cellular Biology” Keratinocyte gene expression is controlled by multiple modules with specific binding sites.
42 citations
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January 2002 in “Skin Pharmacology and Physiology” Reconstructed skin models are useful for studying how skin processes certain chemicals.
41 citations
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July 2020 in “Colloids and surfaces. B, Biointerfaces” Different hair protein amounts change the strength of keratin/chitosan gels, useful for making predictable tissue engineering materials.
41 citations
,
November 2019 in “Journal of Ultrasound in Medicine” Ultrasound can help detect early signs and severity of hidradenitis suppurativa.
41 citations
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May 2012 in “Advanced Healthcare Materials” Human hair keratins improve cell adhesion and growth on culture surfaces.
41 citations
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May 2020 in “Frontiers in immunology” Hidradenitis suppurativa might be a type of autoinflammatory skin disease.
41 citations
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December 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” Deleting MED1 in skin cells causes hair loss and skin changes.