research Repurposing Metformin for Dermatological Use: Mechanisms, Evidence, and Clinical Perspectives
Metformin shows promise for treating skin conditions, but more research is needed.
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150-180 / 1000+ results research Cell death by cornification
Cornification is how skin cells die to form the protective outer layer of skin, hair, and nails.
research Impact of Stat3 activation upon skin biology: A dichotomy of its role between homeostasis and diseases
Stat3 helps skin heal but can also cause skin diseases if overactive.
research Hair cycle and hair pigmentation: dynamic interactions and changes associated with aging
As people age, their hair follicles produce less pigment, leading to gray and white hair, due to factors like reduced enzyme activity and damage to melanocyte DNA.
research Apoptosis and cutaneous biology
Apoptosis is crucial for healthy skin and treating skin diseases.
research When the Circadian Clock Meets the Melanin Pigmentary System
Silencing certain circadian clock genes increases skin pigmentation.
research Retinoids and Phototherapy for Psoriasis
Retinoids and narrowband UVB phototherapy are effective for treating psoriasis and can reduce treatment time when used together.
research Store-operated calcium channels in skin
Calcium channels are vital for normal skin function and their dysfunction can lead to skin issues.
research The secondary role of UV light in swimmers melanoma genesis
Hydrogen peroxide is a major risk factor for melanoma in swimmers, more than UV light.
research Vitamin D and Skin: An Review and Update
Vitamin D is important for skin health and can help treat and prevent various skin conditions.
research Low-Intensity Ultrasound as a Potential Intervention Strategy to Protect Human Scalp Hair Follicles from Taxane-Induced Toxicity
Low-intensity ultrasound may help protect hair follicles from chemotherapy-induced hair loss.
research Disorders of Hair Pigmentation
Hair color is determined by melanin and can be affected by genetic conditions like albinism.
research Epidermal stem cell lineages
Epidermal stem cells are crucial for skin health and problems with them can cause issues like poor wound healing, cancer, and aging.
research Editor's Choice
Organ transplant recipients have a higher risk of skin cancer over time, atopic dermatitis skin shows unusual bacterial and fungal patterns, a new tool for measuring hidradenitis suppurativa severity was created, and gene expression changes in male baldness suggest new treatments.
research Onycholemmal Carcinoma
A rare nail bed cancer was successfully treated with no recurrence after 4 years.
research A Case of Onycholemmal Carcinoma in a 77-Year-Old Man
The man died from lung cancer, not the rare nail tumor.
research Clinical Snippets
Early sunburn treatment with certain inhibitors may reduce skin cancer risk.
research Oxidative Stress and Skin Diseases: The Role of Lipid Peroxidation
Lipid peroxidation worsens skin diseases but may help treat cancer.
research Loss of ERBB2 and ERBB3 Receptors Impacts Epidermal Differentiation in Mice
Losing both ERBB2 and ERBB3 receptors in mice causes significant skin problems and inflammation.
research Unexpected Autocrine Role of Vascular Endothelial Growth Factor in Squamous Cell Carcinoma
VEGF helps squamous cell carcinoma grow in ways beyond just blood vessel formation.
research Cellular and Immunological Aspects of Basel Cell Carcinoma
Basal cell carcinoma cases are rising globally.
research Cellular and Immunological Aspects of Basel Cell Carcinoma
Basal cell carcinoma cases are rising globally.
research Dermatologic therapy: December 1987 to December 1988
New skin treatments in 1987-1988 showed effectiveness for various conditions, but some had side effects or risks.
research The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle
P-cadherin is important for hair growth and health, and its problems can cause hair and skin disorders.
research Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis
CXCR2 in skin cells promotes tumor growth.
research Abstract 5219: The role of MEK and Antizyme in keratinocyte stem cell expansion and differentiation
Antizyme reduces tumor growth and normalizes skin cell development affected by MEK.
research Abstract 5216: Impact of Stat3 deletion or activation on keratinocyte stem/progenitor cells
Stat3 influences keratinocyte stem cell behavior, affecting differentiation and migration.
research Abstract 4300: Constitutive activation of Stat3 increases hair follicle progenitor population at the expense of bulge region keratinocyte stem cells
Stat3 activation increases hair follicle progenitors but reduces bulge region stem cells.
research Abstract 3889: Cyclin-dependent kinase 4 levels affect the number of hair follicle stem cells in mouse epidermis
CDK4 levels affect the number of hair follicle stem cells in mice.
research Abstract 1489: Basal cell carcinomas express functional indoleamine 2,3-dioxygenase (IDO) which may confer immunoprotection
Basal cell carcinomas may use IDO to protect themselves from the immune system.