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GlossaryKeratinocyte Growth Factor

stimulates skin and hair cell growth and repair

Keratinocyte Growth Factor (KGF), also known as Fibroblast Growth Factor 7 (FGF-7), is a protein that plays a crucial role in the growth and repair of skin and hair. It specifically stimulates the proliferation and differentiation of keratinocytes, which are the primary cells found in the outer layer of the skin and hair follicles. This makes KGF important in wound healing and potentially beneficial in treating conditions like alopecia.

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research Research progress and strategies for the biosynthesis of keratinocyte growth factor-2 (KGF-2) in Arabidopsis thaliana

May 2025 in “PeerJ”

Using Arabidopsis thaliana to produce KGF-2 is a promising, cost-effective method for hair growth and wound healing products.

research Effects of recombinant human keratinocyte growth factor-2 on hair regeneration in experimental bald rats

January 2012

rhKGF2 significantly promotes hair growth and follicle development.

Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

research Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

16 citations , February 2007 in “Plastic and Reconstructive Surgery”

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

34 citations , March 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research Growth factor mimetics for skin regeneration: In vitro profiling of primary human fibroblasts and keratinocytes

3 citations , May 2021 in “Archiv der Pharmazie”

SUN11602 and ONO-1301 could help in skin healing and creating artificial skin.

research Corticotropin-Releasing Factor Down-Regulates Hair Growth-Related Cytokines in Cultured Human Dermal Papilla Cells

1 citations , December 2014 in “Journal of the Society of Cosmetic Scientists of Korea”

CRF can cause hair loss, but blocking its receptors might prevent this.

Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD71 Positive Keratinocyte Cells

research Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD 71 (α6bri/CD71dim) Positive Keratinocyte Cells

17 citations , February 2015 in “International Journal of Molecular Sciences”

A special mix from certain skin cells can help hair grow by making hair root cells grow faster and activating growth signals.

Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22

52 citations , May 2015 in “PLOS Genetics”

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

research Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion

134 citations , January 2010 in “Biomedical research”

Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.

research 216 Human hair follicles can “smell”: OR2AT4-mediated hair growth regulation

August 2016 in “Journal of Investigative Dermatology”

Human hair follicles have a scent receptor that can influence hair growth.

research Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells

39 citations , December 2011 in “PLoS ONE”

Radiofrequency exposure can stimulate hair growth by increasing IGF-1 in hair follicle cells.

The Role of Moracin M in Promoting Hair Growth: Insights into Mechanisms of WNT/β-Catenin Pathway Activation and Angiogenesis Enhancement in Human Dermal Papilla Cells

research The Role of Moracin M in Promoting Hair Growth: Insights into Mechanisms of WNT/β- Catenin Pathway Activation and Angiogenesis Enhancement in Human Dermal Papilla Cells

November 2024 in “Research Square (Research Square)”

Moracin M boosts hair growth by activating key pathways and promoting cell growth.

research Keratinocyte Cytokine Networks Associated with Human Melanocytic Nevus Development

5 citations , September 2018 in “Journal of Investigative Dermatology”

Keratinocyte cytokines and genetic variations influence the development of moles and skin pigmentation.

research The Experimental Studies of YangHyulEum Gami-Bang Extracts on the Hair Growth Effect

1 citations , August 2016 in “Hanbang an'i'bi'in'hu pibu'gwa haghoeji”

YangHyulEum Gami-Bang extract may help treat hair loss.

research ROCK inhibitor Y-27632 maintains the propagation and characteristics of hair follicle stem cells.

12 citations , January 2018 in “PubMed”

Y-27632 helps hair follicle stem cells grow and keep their abilities.

research Depletion of Gsdma1/2/3 alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR–Stat3/Akt pathway

6 citations , December 2023 in “Journal of Molecular Cell Biology”

Removing Gsdma1/2/3 genes reduces skin cell overgrowth by blocking a specific cell pathway.

research Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin

April 2024 in “International journal of molecular sciences”

Dermal factors are crucial in regulating melanin production in skin.

research Strengthening the Skin with Topical Delivery of Keratinocyte Growth Factor-1 Using a Novel DNA Plasmid

23 citations , January 2014 in “Molecular Therapy”

Applying a special DNA plasmid to the skin can make it thicker and stronger.

research Keratinocyte Growth Factor Modified Messenger RNA Accelerating Cell Proliferation and Migration of Keratinocytes

11 citations , October 2018 in “Nucleic Acid Therapeutics”

Modified KGF mRNA helps skin cells grow and move faster, which may improve wound healing.

Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum Copticum Seeds

research Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum copticum (L.) Link Seeds

August 2018

Ajwain seed extract improved skin healing and hair growth in a mouse skin irritation model.

research Effect of Ficus carica leaf extract on the gene expression of selected factors in HaCaT cells

16 citations , April 2017 in “Journal of Cosmetic Dermatology”

Ficus carica leaf extract may help treat skin disorders by reducing inflammation and androgen effects in skin cells.

Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

research Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts

20 citations , January 2019 in “Journal of dermatological science”

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

Phosphatidic Acid Has Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

research Phosphatidic Acid Has a Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

46 citations , August 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

Phosphatidic acid may help hair grow by affecting cell growth pathways.

research 28-Year-Old Female with Diffuse Thinning of the Scalp after Isotretinoin and Oral Contraceptives

January 2022 in “Clinical Cases in Dermatology”

Some hair loss from medication may reverse after stopping the drug, but treatment options are limited and ongoing research is needed.

research Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion

April 2012 in “Cancer research”

Blocking mTORC1 may help prevent skin cancer by stopping the growth of certain skin stem cells.

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research A ‘hot’ new twist to hair biology – involvement of vanilloid receptor‐1 signaling in human hair growth control

2 citations , September 2004 in “Experimental Dermatology”

VR1 signaling can inhibit hair growth by affecting cell processes and increasing hair growth inhibitors.

research LB1604 The role of polyunsaturated fatty acids on hair growth

August 2018 in “Journal of Investigative Dermatology”

Polyunsaturated fatty acids, like arachidonic acid and eicosapentaenoic acid, can promote hair growth and may help treat hair loss.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research Electron microscopy in dermatology--basic and clinical research : proceedings of the Joint Meeting for the Japanese Society for Ultrastructural Cutaneous Biology and the Society for Cutaneous Ultrastructure Research, Nara, Japan, 24-27 October 1993

January 1994 in “Medical Entomology and Zoology”

Electron microscopy helps understand skin structure and diseases.