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GlossaryKeratinocyte Proliferation

process where skin cells multiply to regenerate and heal

Keratinocyte proliferation refers to the process by which keratinocytes, the primary cells in the outer layer of the skin, multiply and produce new cells. This process is crucial for skin regeneration and healing, as it helps replace dead or damaged skin cells and maintain the skin's protective barrier. For professionals, understanding keratinocyte proliferation is essential for studying skin conditions and developing treatments for disorders like psoriasis and alopecia.

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Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

research Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P

125 citations , September 2001 in “The FASEB Journal”

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

research Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair folliclesin vitro

60 citations , May 2014 in “British Journal of Dermatology”

Caffeine affects hair growth and health differently in men and women.

research Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation

49 citations , November 2013 in “The Journal of Steroid Biochemistry and Molecular Biology”

Vitamin D receptor helps control skin cell growth and hair development.

The TFIID Subunit TAF4 Regulates Keratinocyte Proliferation and Has Cell-Autonomous and Non-Cell-Autonomous Tumor Suppressor Activity in Mouse Epidermis

research The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis

28 citations , July 2007 in “Development”

TAF4 is important for skin cell growth and helps prevent skin cancer in mice.

research Expression ofSfrp2Is Increased in Catagen of Hair Follicles and Inhibits Keratinocyte Proliferation

25 citations , January 2014 in “Annals of Dermatology”

Sfrp2 increases during hair follicle catagen phase and slows keratinocyte growth.

research WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation

18 citations , January 2013 in “Journal of Investigative Dermatology”

WIF1 helps keep skin stem cells inactive to prevent excessive cell growth.

research Impaired Keratinocyte Proliferative and Clonogenic Potential in Transgenic Mice Overexpressing 14-3-3σ in the Epidermis

15 citations , June 2011 in “Journal of Investigative Dermatology”

Overexpressing 14-3-3σ in mice skin reduces cell growth and hair density.

research Keratinocyte Growth Factor Modified Messenger RNA Accelerating Cell Proliferation and Migration of Keratinocytes

11 citations , October 2018 in “Nucleic Acid Therapeutics”

Modified KGF mRNA helps skin cells grow and move faster, which may improve wound healing.

Xenobiotics In Vitro: The Influence of L-Cystine, Pantothenate, and Miliacin on Metabolic and Proliferative Capacity of Keratinocytes

research Xenobiotics in Vitro: The Influence ofL-Cystine, Pantothenat, and Miliacin on Metabolic and Proliferative Capacity of Keratinocytes

9 citations , January 2006 in “Cutaneous and ocular toxicology”

L-cystine, D-pantothenat, and miliacin together significantly boost keratinocyte growth and metabolism.

research Norepinephrine Regulates Keratinocyte Proliferation to Promote the Growth of Hair Follicles

8 citations , January 2016 in “Cells tissues organs”

Norepinephrine helps skin cells grow, which is important for hair growth.

research Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt^WT mice

8 citations , September 2013 in “Molecular carcinogenesis”

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

research Differential effects of Wnt5a on the proliferation, differentiation and inflammatory response of keratinocytes

6 citations , December 2017 in “Molecular Medicine Reports”

Wnt5a may contribute to psoriasis by reducing skin cell growth, blocking skin cell maturation, and increasing inflammation.

research Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation

2 citations , July 2017 in “Oncology Letters”

Lacking cyclin D3 reduces skin cancer growth without affecting normal skin cell growth.

research 0843 N6-methyladenosine RNA modification promotes keratinocyte proliferation and cutaneous wound repair through regulation of MTOR stability

1 citations , July 2025 in “Journal of Investigative Dermatology”

Increasing m6A levels can improve skin cell growth and wound healing.

research Hair Growth Promoting Effects of Kesh-Kanti-Expert-Oil are Mediated Through Keratinocyte Proliferation and Modulation in Follicular Microenvironment

November 2025 in “Pharmacological Research - Natural Products”

Kesh Kanti Expert Oil promotes hair growth and protects hair health.

research The involvement of Elf5 in regulating keratinocyte proliferation and differentiation processes in skin

January 2025 in “PLoS ONE”

Elf5 controls skin cell growth and development, making it a potential target for skin treatments.

research 085 Dermal papilla cells control hair follicle matrix keratinocytes proliferation through versican

July 2024 in “Journal of Investigative Dermatology”

Versican in dermal papilla cells is crucial for healthy hair growth.

Dermal Fibroblasts Enhance Growth Factors Production by Androgens and Modulate Keratinocyte Proliferation and Differentiation

research 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Androgens increase growth factors in skin cells, which may lead to acne.

research 1433 Role of BNC1 in keratinocytes proliferation and migration: A critical regulator of wound healing?

April 2018 in “Journal of Investigative Dermatology”

Basonuclin 1 (BNC1) helps skin cells multiply and move, which is crucial for wound healing.

research Proliferation and Differentiation of Cultured Human Keratinocytes is Modulated by 1,25(OH)₂D₃ and Synthetic Vitamin D₃ Analogues in a Cell Density‐, Calcium‐ and Serum‐Dependent Manner*

39 citations , January 1997 in “Pharmacology & toxicology”

Vitamin D3 and its analogues affect skin cell growth and development depending on cell density, calcium levels, and serum presence.

Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes

research Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice

October 2014 in “Cancer research”

Blocking mTORC1 reduces skin tumor growth in mice.

research <p>L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes</p>

2 citations , August 2020 in “Clinical, Cosmetic and Investigational Dermatology”

The hair-growth formula with L-cystine helps protect and grow hair cells.

Improvement of Androgenetic Alopecia with Topical Sophora Flavescens Aiton Extract, and Identification of the Two Active Compounds in the Extract That Stimulate Proliferation of Human Hair Keratinocytes

research Improvement of androgenetic alopecia with topicalSophora flavescensAiton extract, and identification of the two active compounds in the extract that stimulate proliferation of human hair keratinocytes

11 citations , October 2015 in “Clinical and Experimental Dermatology”

Sophora flavescens extract helps hair growth and treats hair loss.

research Sulfated hyaluronan‐containing artificial extracellular matrices promote proliferation of keratinocytes and melanotic phenotype of melanocytes from the outer root sheath of hair follicles

8 citations , March 2019 in “Journal of Biomedical Materials Research Part A”

Sulfated hyaluronan in collagen helps hair follicle cells grow and develop better for skin grafts.