19 citations
,
July 1994 in “International Journal of Dermatology” A 9-year-old boy had a calcium deposit nodule on his earlobe.
65 citations
,
June 2003 in “EMBO journal” Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.
245 citations
,
January 1998 in “Genes & Development” Hoxc13 gene is essential for hair, nail, and papilla development.
November 2021 in “American Journal of Tropical Medicine and Hygiene” Marking nuts can cause skin irritation and allergies.
109 citations
,
November 2011 in “Nature Neuroscience”
July 2018 in “Elsevier eBooks” Acne keloidalis nuchae is a chronic skin condition more common in African men, causing itchy or painful bumps and can lead to permanent hair loss if not treated early.
The naked mutation in mice causes hair loss and helps identify keratin genes.
December 2025 in “Nature Communications” Club-like receptors detect light touch but not whisking.
2 citations
,
December 2013 in “The Journal of Dermatology” Light tickling can be unpleasant and may feel worse for individuals with autism.
August 2023 in “Journal of the European Academy of Dermatology and Venereology” Onycholemmal horn is a rare nail tumor in elderly women, treated by surgical removal.
January 2020 in “Medpulse International Journal of Medicine” Nail and hair changes are common in severe chronic kidney disease and should be treated to improve patients' quality of life.
17 citations
,
January 2013 in “Journal of Cutaneous Pathology” The onychodermis helps anchor the nail bed and may aid in nail formation.
September 2023 in “Nature communications” Alk1 in specific cells is crucial for proper nerve branching and hair function.
December 2023 in “Royal Society of Chemistry eBooks” Nails are a useful alternative to hair for analyzing long-term substance exposure.
101 citations
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August 2001 in “The Journal of Cell Biology” A new keratin 6 type in mice explains why some mice without certain keratin genes still have normal hair and nails.
June 2021 in “The Journal of Family Practice” A 69-year-old woman has a fast-growing hand lesion that didn't improve with salicylic acid.
62 citations
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January 2000 in “Developmental dynamics” Notch-related genes play a key role in the development and cycling of hair follicles.
January 2000 in “The Mouseion at the JAXlibrary (Jackson Laboratory)” The lanceolate hair-J mutation in mice helps understand human hair disorders like Netherton's syndrome.
2 citations
,
January 2007 in “Actas Dermo-Sifiliográficas” Two cases of hairy elbows syndrome were described, with normal skin texture and symmetrical hair growth.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Deleting the CD271 gene in mouse skin cells leads to disorganized skin and increased hair growth, suggesting CD271 is important for skin health.
10 citations
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May 1994 in “Journal of Investigative Dermatology” August 2019 in “Journal of the American Academy of Dermatology” Older adults may experience painful finger pitting due to nerve changes in aging skin, and treatments can help reduce symptoms.
22 citations
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October 2007 in “Journal of Investigative Dermatology” Stem cells in mouse nails are found in the nail matrix and may control nail growth.
May 2017 in “The journal of immunology/The Journal of immunology” Patients with certain FoxN1 gene mutations have severe immune issues but normal skin and hair.
May 2018 in “Dermatologic Surgery” 37 citations
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June 2000 in “Experimental dermatology” The Lanceolate hair-J mutation in mice mimics human hair disorders like Netherton's syndrome.
1 citations
,
April 2008 in “Pigment Cell & Melanoma Research” Foxn1 is essential for hair pigmentation by directing pigment transfer to hair cells.
May 2018 in “The journal of immunology/The Journal of immunology” Mutations in the FOXN1 gene cause severe immune issues but don't affect hair and nails.
July 2023 in “Journal of the ASEAN Federation of Endocrine Societies” Metyrapone effectively stabilizes severe Cushing's disease symptoms before surgery.