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Biotransformation of Finasteride by Ocimum Sanctum L., and Tyrosinase Inhibitory Activity of Transformed Metabolites: Experimental and Computational Insights

research Biotransformation of Finasteride by Ocimum sanctum L., and tyrosinase inhibitory activity of transformed metabolites: Experimental and computational insights

3 citations , August 2014 in “Steroids”

Fermentation of Finasteride with Ocimum sanctum L. creates new metabolite that inhibits tyrosinase.

Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions

14 citations , February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

research Ruxolitinib: A novel molecule in the management of dermatological disorders

February 2026 in “Indian Journal of Skin Allergy”

Ruxolitinib cream effectively treats skin conditions like atopic dermatitis and vitiligo with minimal side effects.

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride.

20 citations , October 1995 in “PubMed”

iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

research iTRAQ-based quantitative proteomics revealing the therapeutic mechanism of a medicinal and edible formula YH0618 in reducing doxorubicin-induced alopecia by targeting keratins and TGF-β/Smad3 pathway

June 2024 in “Heliyon”

YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.

research PKCδ/MAPKs and NF-κB Pathways are Involved in the Regulation of Ingenane-Type Diterpenoids from Euphorbia neriifolia on Macrophage Function

9 citations , June 2021 in “Journal of Inflammation Research”

Euph E and Euri A from Euphorbia neriifolia help control inflammation and immune response in cells.

research Table 2_Computational drug discovery of potential 5α-reductase phytochemical inhibitors and hair growth promotion using in silico techniques.xlsx

May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Jamogenin and other molecules from plants may help treat hair loss.

research [Finasteride--ris of "unintentional doping"].

November 2005 in “PubMed”

research Tamoxifen-induced androgenetic alopecia in a dialysis patient with sclerosing encapsulating peritonitis (SEP)

January 2004 in “Indian Journal of Nephrology”

Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite

research Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite

16 citations , October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

research IMMUNOHISTOCHEMICAL DEMONSTRATION OF POLY(ADENOSINE DIPHOSPHATE‐RIBOSE) SYNTHESIS IN HUMAN SKIN

13 citations , April 1982 in “The Journal of Dermatology”

Poly(ADP-ribose) synthesis is linked to skin cell differentiation.

research Table 1_Computational drug discovery of potential 5α-reductase phytochemical inhibitors and hair growth promotion using in silico techniques.xlsx

May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Jamogenin and other molecules from plants may help treat hair loss.

research Allergic contact dermatitis produced by canrenone

August 2007 in “Contact Dermatitis”

A woman had an allergic skin reaction to a hair loss treatment containing canrenone.

research Risk of finasteride-related suicidal ideation

September 2022 in “Reactions Weekly”

research Nilontinib induced keratosis pilaris atrophicans

10 citations , August 2016 in “Dermatology Online Journal”

Nilotinib can cause skin issues like red bumps and hair loss.

Ranitidine And Finasteride Inhibit The Synthesis And Release Of Trimethylamine N-Oxide And Mitigate Its Cardiovascular And Renal Damage Through Modulating Gut Microbiota

research Ranitidine and finasteride inhibit the synthesis and release of trimethylamine N-oxide and mitigates its cardiovascular and renal damage through modulating gut microbiota

14 citations , January 2020 in “International Journal of Biological Sciences”

Ranitidine and finasteride lower TMAO levels, reducing heart and kidney damage by changing gut bacteria.

research Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications

4 citations , December 2013 in “Acupuncture and related therapies”

N-acetyl-cysteine shows promise in treating various diseases and may improve skin and hair conditions, but more research is needed on dosages and long-term effects.

research 616 Endoplasmic reticulum stress upregulates NKG2D ligands in the hair follicle

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Stress in hair follicle cells increases certain immune-related proteins, which might contribute to hair loss conditions.

research Design and synthesis of novel Azasteroids and Pseudoazulenyl nitrones

December 2016

The research created new azasteroids and pseudoazulenyl nitrones, which could be useful in medicine.

research Effects of Dietary Niacin Supplemental Level on Meat Quality and Hair Follicle Development of Growing Rex Rabbits

January 2017

research finasteride, n.

March 2023 in “Oxford University Press eBooks”

research Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

11 citations , March 2024 in “Current Issues in Molecular Biology”

Ginsenoside compound K shows promise for treating metabolic diseases like diabetes and obesity.

TYK2 Inhibition with Deucravacitinib Improves Clinical Outcomes and Resolves Interferon-Driven Inflammation in Lichen Planopilaris

research TYK2 Inhibition with Deucravacitinib Improves Clinical Outcomes and Resolves Interferon-Driven Inflammation in Lichen Planopilaris

March 2026

Deucravacitinib improves symptoms and reduces inflammation in Lichen Planopilaris.

The Liver Monooxygenase System in Patients with Alopecia

research FC054 The liver monoxygenase system in patients with alopecia

September 1997 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Alopecia patients have a less active liver monoxygenase system, which can be treated with photochemotherapy and system inducers.

research The effects of methylated flavonoids on depression-like activity and pro-inflammatory cytokine thresholds in mice induced by repeated finasteride administration

1 citations , January 2021 in “European Journal of Inflammation”

Methylated flavonoids may effectively reduce depression and inflammation caused by finasteride.

research KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis

13 citations , March 2021 in “British Journal of Pharmacology”

KY19382 helps regrow hair and create new hair follicles.

research Fate of Mimosine, Concentration of Blood Metabolites and Thyroid Hormones of Sheep Fed with Leucaena and Glyricidia Leaf Meal

May 2018 in “Pakistan journal of nutrition”

Feeding sheep up to 30% Leucaena leaf meal does not harm their blood metabolites and thyroid hormones.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

research Identification of xenobiotics interfering with 5 α -reductase (SRD5A2) activity

February 2026 in “Toxicology Letters”

MK-0773 is a moderate inhibitor of the SRD5A2 enzyme.

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