54 citations
,
November 1994 in “Differentiation” Trichohyalin is found in non-hair tissues and works with filaggrin in certain skin areas and conditions.
13 citations
,
November 2007 in “Journal of Structural Biology” Keratin heterodimers are preferred for their specific and structural advantages.
126 citations
,
January 1987 in “Current topics in developmental biology/Current Topics in Developmental Biology” Different keratin proteins are expressed in various epithelial cells at different stages, affecting cell structure and function.
32 citations
,
April 2014 in “The journal of investigative dermatology/Journal of investigative dermatology” Loss of keratin K2 causes skin problems and inflammation.
69 citations
,
January 2009 in “Advances in Materials Science and Engineering” Wool keratin is reactive, biocompatible, biodegradable, and can model keratin from other sources.
2 citations
,
March 1994 in “Oncology Reports” Keratoacanthomas and squamous cell carcinomas have similar keratin patterns, making them hard to tell apart.
28 citations
,
October 1985 in “The Journal of Cell Biology” Researchers isolated and identified structural components of human hair follicles, providing a model for studying hair formation.
55 citations
,
January 2013 in “International Journal of Cosmetic Science” African hair's keratin structure is influenced by its higher lipid content.
211 citations
,
April 2018 in “Cold Spring Harbor Perspectives in Biology” Keratins are crucial for cell structure, growth, and disease risk.
235 citations
,
July 1999 in “Journal of biological chemistry/The Journal of biological chemistry” Human hair is made up of different keratins, some strong and some weak, with specific types appearing at various stages of hair growth.
109 citations
,
September 2011 in “Human molecular genetics online/Human molecular genetics” New treatments targeting specific genes show promise for treating keratin disorders.
7 citations
,
May 2024 in “Tissue Barriers” The skin's outer layer relies on lipids and proteins to protect against damage.
482 citations
,
June 1979 in “Proceedings of the National Academy of Sciences” Keratins provide structural strength in epithelial cells and help identify cell origins.
53 citations
,
September 2004 in “American journal of medical genetics. Part C, Seminars in medical genetics” Mutations in keratin genes cause cell fragility and various skin disorders.
January 1990 in “The Nishinihon Journal of Dermatology” Follicular structures help differentiate keratoacanthoma from squamous cell carcinoma.
44 citations
,
March 2019 in “Experimental Dermatology” A wide range of proteins are integrated into the skin's protective layer.
28 citations
,
July 2000 in “PubMed” Hair structure forms the same way inside and outside the body.
63 citations
,
December 1998 in “Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology” The study improved understanding of keratin fiber structure by showing consistent microfibril diameter but varying distances and electron density profiles.
87 citations
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November 2002 in “Journal of Investigative Dermatology”
7 citations
,
April 2012 in “Biomolecular concepts” Keratin is crucial for keeping skin cells healthy and its changes can lead to diseases and affect cell behavior.
41 citations
,
January 2001 in “Journal of Investigative Dermatology” January 2000 in “Acta Academiae Medicine Militaris Tertiae” Different keratins in hair follicles can help identify hair tumor origins.
13 citations
,
May 2016 in “International journal of biological macromolecules” Keratin's mechanical properties are influenced by hydrogen bonds and secondary structure, and can be improved with the SPD-2 peptide.
87 citations
,
July 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.
2 citations
,
June 2001 in “Medical Electron Microscopy” Trichilemmal cysts may form from hair follicle outer root sheath growth.
76 citations
,
December 2011 in “Journal of Cell Science” Different keratin types have unique amino acid patterns that are evolutionarily conserved.
86 citations
,
May 2002 in “Journal of Investigative Dermatology” A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.
248 citations
,
April 1988 in “Differentiation” Human and bovine hair follicles have distinct cytokeratins specific to hair-forming cells.
1 citations
,
October 2022 in “Bioengineering” Keratin helps skin cells mature when added to a collagen mix, which could be important for skin and hair health.