July 2024 in “Journal of Investigative Dermatology” The Fas/FasL pathway may play a role in alopecia areata.
January 2005 in “Life sciences” Targeting LPA could help treat skin disorders.
1 citations
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August 2019 in “Journal of Investigative Dermatology” PRDX5 enzyme may contribute to alopecia areata by affecting oxidative stress and autoimmunity.
April 2023 in “Journal of Investigative Dermatology” Human TMEM2 does not break down hyaluronan but helps control its metabolism.
June 2024 in “British Journal of Dermatology” DLQI is a reasonable quality-of-life measure for alopecia patients, but more research is needed.
126 citations
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October 1998 in “Experimental Dermatology” The hr gene is crucial for skin and hair health, with mutations causing hair disorders.
October 2024 in “Benha Medical Journal” Patients with Alopecia Areata have higher levels of certain inflammatory markers.
81 citations
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July 2008 in “The Journal of Clinical Endocrinology and Metabolism” Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.
October 2025 in “The Egyptian Journal of Hospital Medicine” Lower adiponectin and higher leptin levels may predict hair loss in alopecia areata.
March 2024 in “Skin research and technology” High CRP levels could indicate vitamin D deficiency in people with alopecia areata.
4 citations
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April 2018 in “Journal of Investigative Dermatology” Hydroxypinacolone retinoate is a potent anti-aging ingredient for skin that is more effective and less irritating than other forms of retinoids.
44 citations
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June 2017 in “The EMBO Journal” LPA3 signaling in the uterus is crucial for placental formation and fetal development.
39 citations
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May 2002 in “Oral Microbiology and Immunology” Testosterone increases cell growth and reduces IL-6 in gum cells.
April 2025 in “Skin Appendage Disorders” Vitamin D may help reduce severity and relapse of alopecia areata.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” People with alopecia areata have fewer IL-10 producing immune cells, which might contribute to the condition.
11 citations
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March 2013 in “Gene” A certain genetic variation in the IL1A gene may lower the risk of a hair loss condition in Chinese people.
3 citations
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October 2025 in “Journal of Materials Science Materials in Medicine” Hyaluronic acid is useful in cancer treatment, wound healing, and managing diseases due to its tissue compatibility and drug delivery abilities.
151 citations
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August 2011 in “The EMBO Journal” The enzyme PA-PLA1α is important for proper hair follicle development.
24 citations
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June 2021 in “Annals of Translational Medicine” Human placental extract may help treat osteoarthritis, but more research is needed.
April 2026 in “International Journal of Biological Macromolecules”
August 2025 in “International Journal of Contemporary Pediatrics” HLD10 can include increased body hair and Mongolian spots.
November 2022 in “Journal of the Endocrine Society” Estrogen deficiency can reduce the enzyme activity needed to activate vitamin D.
28 citations
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April 2017 in “Journal of cosmetic dermatology” Low vitamin D can worsen pediatric alopecia areata.
77 citations
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June 2002 in “Journal of Investigative Dermatology” CD44 variant changes start alopecia areata, but don't maintain it.
9 citations
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August 2023 in “Journal of Investigative Dermatology” IL-15 helps hair grow longer and stronger by extending the growth phase and reducing cell death.
7 citations
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December 2016 in “Journal of the American Academy of Dermatology” NKG2D+CD4+ T cells are higher in alopecia areata patients and may be involved in the disease.
October 2011 in “Iranian Journal of Dermatology” Men with male pattern baldness may have a higher risk of heart disease due to increased levels of a specific lipid in their blood.
August 2021 in “Journal of Investigative Dermatology” ILC1-like cells can cause alopecia areata by disrupting hair follicle immunity, suggesting a new treatment approach.
January 2023 in “International Journal of Zoological Investigations” Certain genetic variations in IL-16 may increase the risk of alopecia areata.