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Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.

Testosterone's muscle-building effects do not require its conversion to DHT.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Testosterone replacement may help post-menopausal women with androgen insufficiency, but more research is needed on its benefits and risks.

Nandrolone and oxandrolone could help treat male health issues like muscle loss and low testosterone.

Gene therapy shows promise for enhancing physical traits but faces ethical, safety, and regulatory challenges.

Finasteride can cause muscle pain and high creatine kinase levels, but stopping the medication may resolve symptoms.

Testosterone and dihydrotestosterone have similar effects on body composition and metabolic health in men.

Androgen therapy can help with symptoms like low libido in women, but more research is needed to understand its long-term safety and effects on health.

Retinoic acid affects male and female muscle energy use and function differently.

Women with PCOS have higher body fat and worse insulin resistance and lipid profiles.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.

Transgender women have similar fitness to cisgender women, while transgender men have higher fat and lower strength than cisgender men; hormone therapy affects body composition and strength.

Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

GLP-1 receptor agonists help with weight loss but need to be combined with other treatments for best results.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Muscles can make their own androgens, which may help muscle growth.

Testosterone use for muscle growth can cause hair loss in males.

Caloric restriction improves skin and fur structure but can cause muscle loss and movement issues.

The new rodent model successfully mimics non-lean human PCOS symptoms.

Creatine monohydrate is safe and effective for muscle recovery and performance, especially for those with low creatine levels.