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GlossaryLentivirus

virus that integrates into host DNA, used in gene therapy

A lentivirus is a type of virus that belongs to the retrovirus family and is known for its ability to infect and integrate into the DNA of host cells. These viruses can cause long-term, chronic infections and are used in gene therapy due to their ability to deliver genetic material into cells. HIV (Human Immunodeficiency Virus) is a well-known example of a lentivirus.

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research Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter

52 citations , October 2007 in “Molecular Therapy”

Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.

research Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation

13 citations , June 2014 in “Molecular therapy”

The lentiviral array can monitor and predict gene activity during stem cell differentiation.

research Characterization of factors that determine lentiviral vector tropism in skin tissue using an ex vivo model

7 citations , March 2011 in “The Journal of Gene Medicine”

Lentiviral vector effectiveness in skin is influenced by external factors, not receptor availability.

research Lentivirus‐mediated subcutaneous JAM‐A modification promotes skin wound healing in a mouse model by strengthening the secretory function and proliferation of fibroblasts

5 citations , April 2022 in “Cell Biology International”

JAM-A modification speeds up skin wound healing by boosting fibroblast growth.

research Lentivirus-Mediated Expression of VEGF165 in Rat Hair Follicle Stem Cells

April 2015 in “MOJ Cell Science & Report”

Rat hair follicle stem cells can be used to improve blood vessel growth in engineered skin.

research [Experimental study on vascular endothelial growth factor 165 gene-modified rat hair follicle stem cells mediated by lentiviral vector].

February 2014 in “PubMed”

Modified rat hair follicle stem cells can help create artificial hair follicles, blood vessels, and skin.

research Lentiviral Vector-Mediated Gene Transfer to Human Hair Follicles

6 citations , February 2009 in “Journal of Investigative Dermatology”

research Effect of lentivirus-mediated miR-182 targeting FGF9 on hallux valgus

4 citations , January 2021 in “International Journal of Medical Sciences”

miR-182 may help treat hallux valgus by targeting FGF9.

research Detection of lentiviral constructs for release testing of CAR- T cells using digital droplet PCR

1 citations , May 2019 in “Cytotherapy”

The new ddPCR method reliably detects unwanted viruses in CAR-T cell products, ensuring their safety for patients.

research A matter of life and death: self‐renewal in stem cells

150 citations , December 2012 in “EMBO Reports”

Stem cell self-renewal is complex and needs more research for full understanding.

research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75

6 citations , September 2015 in “Journal of Investigative Dermatology”

Using special RNA to target a mutant gene fixed hair problems in mice.

research Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

6 citations , February 2013 in “Journal of Visualized Experiments”

The method quickly analyzes hair growth genes and shows that blocking Smo in skin cells stops hair growth.

research Transduction‐induced overexpression of Merkel cell T antigens in human hair follicles induces formation of pathological cell clusters with Merkel cell carcinoma‐like phenotype

5 citations , August 2021 in “Experimental dermatology”

Overexpressing Merkel cell virus proteins in human hair follicles can create clusters of cells that resemble Merkel cell cancer.

research Expression of lipid-protein gene PLP2 in Liaoning cashmere goat

3 citations , February 2019 in “Animal biotechnology”

The PLP2 gene affects cashmere fiber quality in goats and is linked to hair growth and loss.

research Th22 is the effector cell of thymosin β15-induced hair regeneration in mice

January 2024 in “Inflammation and regeneration”

Th22 cells are essential for Tβ15-induced hair growth in mice.

research [Effect study of Sonic hedgehog overexpressed hair follicle stem cells in hair follicle regeneration].

July 2023 in “PubMed”

Sonic hedgehog helps hair follicle stem cells grow and can effectively regenerate hair follicles.

Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth After FGF5 Treatment

research Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth after FGF5 Treatment

August 2019 in “Research Square (Research Square)”

Certain long non-coding RNAs in cashmere goats affect hair growth when treated with a specific growth factor.

research Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects

25 citations , June 2017 in “Neuropharmacology”

Increasing TSPO in the brain reduces anxiety and depression.

research The long road traveled in hematopoietic stem cell gene therapy

1 citations , October 2022 in “Molecular therapy”

The FDA approved the first gene therapy for a blood disorder after overcoming early challenges and demonstrating patient benefits.

research Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship

October 2025 in “Influenza and Other Respiratory Viruses”

Certain alkaloids could help create new coronavirus drugs.

research Small RNAs Loom Large During Reprogramming

18 citations , June 2011 in “Cell stem cell”

MicroRNAs can reprogram cells into stem cells faster and more efficiently than traditional methods.

research Hemidesmosomes and Notch signaling regulate epidermal differentiation via delamination

April 2026 in “Development”

Hemidesmosomes and Notch signaling help skin cells mature by moving them to the outer layer.