8 citations
,
October 1989 in “International Journal of Dermatology” Cytochrome P-450 enzymes in the skin help break down various substances and could be targeted to treat skin conditions.
5 citations
,
May 2025 in “Scientific Reports” Phyllanthus emblica leaves show potential for developing new antimalarial drugs with low toxicity.
Fetal environments contain various chemicals that may disrupt hormones.
39 citations
,
November 2016 in “Pharmaceutics” The hair follicle pathway significantly affects how easily water-loving chemicals pass through the skin.
14 citations
,
February 2025 in “Pharmaceutics” Niosomes improve delivery and effectiveness of cosmetic ingredients.
75 citations
,
August 2006 in “International Journal of Pharmaceutics” The eucalyptus oil system improved skin delivery of hormones, but safety concerns remain.
21 citations
,
June 2022 in “Molecules” Perilla frutescens, an East Asian plant, contains 400 bioactive compounds that have various health benefits, including anti-inflammatory, antidepressant, and anticancer effects, and can treat conditions like diabetes, skin allergies, and neurological disorders.
February 2024 in “Pharmaceutical research” Hair follicles affect how well small molecules can pass through the skin, and this varies depending on the molecule's features.
23 citations
,
January 2001 in “International journal of toxicology” St. John's Wort extract and oil safety in cosmetics is unclear; more data needed on photosensitization, toxicity, and human irritation.
38 citations
,
January 2002 in “Biological & Pharmaceutical Bulletin” Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.
35 citations
,
January 2018 in “Skin pharmacology and physiology” Nanoemulsion creams with certain enhancers can greatly increase caffeine delivery through skin.
23 citations
,
September 2018 in “Dermatologic Therapy” Microneedling is a safe and effective way to improve various skin conditions with minimal side effects.
4 citations
,
July 2023 in “Legume Research - An International Journal” Leucaena seeds are nutritious but need treatment to reduce toxicity.
4 citations
,
December 2010 in “Copernican Letters” Synthetic polypeptides in cosmetics may help with anti-aging, but their effectiveness on real skin is uncertain.
1 citations
,
January 2023 in “Skin appendage disorders” Hair oils can worsen seborrheic dermatitis in black patients.
January 1993 in “Side effects of drugs annual” Natural products like propolis are causing more skin allergies, and certain skin treatments and medications have various side effects and risks.
55 citations
,
September 2017 in “Expert Opinion on Drug Discovery” Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.
195 citations
,
January 2008 in “Photochemistry and Photobiology” Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.
105 citations
,
January 2010 in “Mediators of Inflammation” Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.
76 citations
,
July 2019 in “Scientific Reports” Baicalin nanocapsules greatly enhance its anticancer effects on breast cancer cells.
72 citations
,
December 2012 in “Expert Opinion on Drug Delivery” Niosomes are promising for skin drug delivery, offering benefits like improved drug penetration and stability.
72 citations
,
January 2001 in “Drugs” Minoxidil and finasteride treat hair loss; more research needed for other options.
70 citations
,
July 2016 in “Aging” Targeting dermal adipocytes may help combat skin aging.
49 citations
,
September 2008 in “International journal of pharmaceutics” Artificial sebum L closely mimics human sebum for drug delivery research.
43 citations
,
May 1986 in “Clinics in Endocrinology and Metabolism” Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.
39 citations
,
November 2015 in “Nanomedicine” Improved Finasteride delivery for hair loss treatment.
30 citations
,
April 1997 in “European journal of endocrinology” The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.
29 citations
,
September 1990 in “Biochemical Journal” Enzyme purified and characterized for minoxidil sulphation in rat liver.
25 citations
,
June 2011 in “International journal of pharmaceutics” Nanoparticles effectively deliver water-insoluble drugs to hair follicles, stimulating hair growth without irritating the skin.
25 citations
,
December 2013 in “Journal of Investigative Dermatology Symposium Proceedings” New methods like nanoparticles and microneedles show promise for better skin drug delivery, especially for hair disorders.