research Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems
Improved delivery systems can enhance oleanolic acid's effectiveness in treating various conditions.
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research Photostability and toxicity of finasteride, diclofenac and naproxen under simulating sunlight exposure: evaluation of the toxicity trend and of the packaging photoprotection
Sunlight exposure increases drug toxicity; amber glass best for protection.
research Metabolite identification by mass spectrometry of the 5α-reductase inhibitor finasteride in vitro and in vivo
Finasteride's metabolites were identified, helping understand how the drug is processed in the body.
research Isolation and structural identification of a novel minoxidil analogue in an illegal dietary supplement: triaminodil
A new minoxidil-like substance, triaminodil, was found in an illegal hair growth supplement.
research Development of Novel Cosmetic Base Using Sterol Surfactant. II. Solubilizing of Sparingly Soluble Ultraviolet Ray Absorbers†
Sterol surfactants can effectively dissolve UV ray absorbers.
research Clindamycin-Loaded Polyhydroxyalkanoate Nanoparticles for the Treatment of Methicillin-Resistant Staphylococcus aureus-Infected Wounds
Clindamycin-loaded nanoparticles effectively treat MRSA-infected wounds and promote healing.
research Oil-in-Water型ナノエマルションに基づく局所経皮送達システムに関する研究
The nanoemulsion system effectively delivers drugs through the skin and shows promise for treating skin conditions.
research Molecular Docking Studies and ADME Prediction of Novel Isatin Analogs with Potent Anti-EGFR Activity
Some new isatin compounds could be strong cancer-fighting drugs because they fit well in cancer-related proteins and have good drug-like properties.
research P62 Pre-clinical pharmacological and skin penetration profile of LDE255, a novel and specific Smoothened antagonist
LDE225 is a promising skin-applied treatment for basal cell carcinoma with good skin penetration and effectiveness.
research Self-Emulsifying Drug Delivery Systems (SEDDS): Measuring Energy Dynamics to Determine Thermodynamic and Kinetic Stability
Solidified SEDDS improve drug stability and bioavailability better than liquid SEDDS.
research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
New steroid derivatives show promise as anticancer agents, even against resistant cells.
research Nanoemulgels: A new approach for the treatment of skin-related disorders
Nanoemulgels improve skin disorder treatment by delivering drugs more effectively and reducing application frequency.
research Nanostructured lipid carriers promote percutaneous absorption and hair follicle targeting of tofacitinib for treating alopecia areata
Nanostructured lipid carriers effectively deliver tofacitinib to hair follicles, reversing hair loss in alopecia areata.
research Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery
PLGA-based microneedles are promising for safe and effective skin delivery of drugs and vaccines.
![Effect of C-Ring Modifications in Benzo[c]quinolizin-3-ones, New Selective Inhibitors of Human 5α-Reductase 1](/images/research/c687900f-ea40-4de1-8f0b-a5b818951b1c/small/15452.jpg)
research Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5α-reductase 1
Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.
research New ethanol and propylene glycol free gel formulations containing a minoxidil-methyl-β-cyclodextrin complex as promising tools for alopecia treatment
New gel formulas without ethanol and propylene glycol, containing a minoxidil-methyl-β-cyclodextrin complex, have been created for treating hair loss.
research Role of Drug Repurposing in Sustainable Drug Discovery
Drug repurposing speeds up drug development, saves money, and has led to about a third of new drug approvals.
research New Aromatic Esters of Progesterone as Antiandrogens
New progesterone-based compounds can block male hormones.
research 12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis
A new compound slows cancer cell growth and causes cell death by blocking cell cycle progression and increasing cell-damaging molecules.
research Investigation of nanoparticulate formulation intended for caffeine delivery to hair follicles
Nanoparticles with caffeine can be used for slow, continuous hair growth stimulation.
research An overview of current strategies and future prospects in drug repurposing in tuberculosis
Drug repurposing offers promising strategies to improve tuberculosis treatment despite challenges.
research Formulation, Evaluation and Stability Studies of Dutasteride Loaded Niosomal Gel
The gel effectively delivers dutasteride for hair loss treatment and remains stable for 90 days.
research Solubility Preformulation Screening of Minoxidil in Different Natural Oils Using Experimental and Computational Approaches
Minoxidil dissolves best in shea butter, stearic acid, and rosemary oil, which may improve hair growth treatments.
research Coenzyme Q10 phospholipidic vesicular formulations for treatment of androgenic alopecia:ex vivopermeation and clinical appraisal
Coenzyme Q10 vesicular formulations can potentially treat androgenic alopecia by promoting hair growth and thickness.
research Bioequivalence Study of Finasteride Tablets in Human Plasma by HPLC-MS
The test and reference finasteride tablets are bioequivalent.
research Smoothened antagonists for hair inhibition
Two new compounds were found to effectively reduce hair growth in mice.
research Development and Characterization of Thiolated Cyclodextrin-Based Nanoparticles for Topical Delivery of Minoxidil
The new adhesive nanoparticles are effective for delivering Minoxidil to the scalp without skin irritation.
research Medication Repurposing: New Uses for Old Drugs
Old drugs can be used for new treatments, saving time and money, but there are challenges like needing more evidence and legal concerns.
research Hair follicle targeting with curcumin nanocrystals: Influence of the formulation properties on the penetration efficacy
Curcumin nanocrystals in simple gels effectively penetrate hair follicles, but humectants can reduce this efficacy.
research Long-acting microneedle formulations
Microneedles are promising for long-acting drug delivery and can improve patient compliance, but more data is needed to confirm their effectiveness.