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research An engineered ferritin nanocage co-delivery system for targeted hair cells protection and hearing loss attenuation

July 2026 in “Theranostics”

The study presents a ferritin-based nanocage (LR@Fn) as a novel co-delivery system for protecting hair cells and attenuating hearing loss. This system effectively delivers small molecules RG108 and LLY283 directly to the inner ear, overcoming challenges like poor cellular uptake and off-target toxicity. In models of neonatal cisplatin and adult noise-induced hearing loss, LR@Fn demonstrated superior protection of hair cells, reduced synaptic damage, and decreased apoptosis compared to dexamethasone. The treatment also activated the Wnt/β-catenin pathway, contributing to its protective effects. LR@Fn shows promise as a biocompatible platform for targeted inner-ear therapy across various forms of hearing loss.

research hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

3 citations , December 2023 in “Aging”

hsa_circ_0002980 can help stop liver cancer cells from growing and spreading.

research LncRNA018392 promotes the proliferation of Liaoning cashmere goat skin fibroblasts by upregulating CSF1R through binding to SPI1

3 citations , August 2024 in “Molecular Biology Reports”

LncRNA018392 helps goat skin cells grow by increasing CSF1R.

research LncRNA018392 promotes proliferation of Liaoning cashmere goat skin fibroblasts through up-regulation of CSF1R by binding to SPI1

April 2023 in “Research Square (Research Square)”

A specific RNA helps increase the growth of skin cells in Liaoning cashmere goats by working with a protein to boost a growth-related gene.

research effects Of Low-level Laser Therapy (lllt) On Dermal Papilla Cell Proliferation And Insulin-like Growth Factor-1 (igf-1) Secretion From Balding Hair Follicles : #lb12

April 2014

research Integrated multiple machine learning and Mendelian randomization reveal LTF gene as a prognostic biomarker for nonspecific orbital inflammation

August 2025 in “BMC Pharmacology and Toxicology”

The LTF gene may help predict and manage nonspecific orbital inflammation.

research 197 A novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair

August 2016 in “Journal of Investigative Dermatology”

Researchers found a new genetic mutation linked to a hair condition in a Japanese boy.

research Outbreak of recombinant lumpy skin disease virus in yaks: high mortality and systemic pathogenesis in Qinghai-Tibet Plateau yak herds

1 citations , May 2025 in “Frontiers in Veterinary Science”

A severe virus outbreak in yaks on the Qinghai-Tibet Plateau caused high death rates and requires targeted control measures.

research The Function of LPR1 is Controlled by an Element in the Promoter and is Independent of SUMO E3 Ligase SIZ1 in Response to Low Pi Stress in Arabidopsis thaliana

49 citations , January 2010 in “Plant and Cell Physiology”

LPR1 regulates root growth under low phosphate stress independently of SIZ1 in Arabidopsis thaliana.

research Pseudallescheria boydii infection associated with IgG4-related disease

3 citations , September 2022 in “European Journal of Dermatology”

Gene sequencing is crucial for diagnosing Junctional epidermolysis bullosa.

research The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity

55 citations , November 2010 in “Journal of Allergy and Clinical Immunology”

The L412F variant of TLR3 is linked to skin infections, more viral infections, and autoimmune issues.

research CYP3A5 Polymorphism in Circulating Tumor Cells Confers an Increased Disease-Free Survival in DLBCL Patients Treated with R-CHOP

March 2025 in “OncoTargets and Therapy”

A specific genetic trait in tumor cells is linked to longer survival without disease in certain lymphoma patients.

research The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

3 citations , October 1994 in “Journal of Labelled Compounds and Radiopharmaceuticals”

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

research LncRNA RP11-818O24.3 promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway

4 citations , May 2024 in “Cytotechnology”

research Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways

May 2026 in “Scientific Reports”

Overexpression of LRIG3 in skin causes hair loss.

Identification of a Novel Homozygous LAMB3 Mutation in a Chinese Male With Junctional Epidermolysis Bullosa and Severe Urethra Stenosis: A Case Report

research Identification of a novel homozygous LAMB3 mutation in a Chinese male with junctional epidermolysis bullosa and severe urethra stenosis: A case report

September 2022 in “Frontiers in genetics”

A Chinese male with a new genetic mutation has a skin condition and severe urinary issues, with treatments having mixed success.

research Identification of 736T>A mutation of lipase H in Japanese siblings with autosomal recessive woolly hair

7 citations , February 2011 in “Journal of dermatology”

The 736T>A mutation in the LIPH gene is common in Japanese people with autosomal recessive woolly hair.

research Birt-Hogg-Dube Syndrome with a Novel Mutation in the FLCN Gene

7 citations , August 2017 in “Genetic testing and molecular biomarkers”

A new mutation in the FLCN gene linked to Birt-Hogg-Dube syndrome was found, suggesting people with certain lung collapse should be tested for this mutation and screened for kidney and colon cancer.

research Novel small‐insertion mutation in the LIPH gene in a patient with autosomal recessive woolly hair/hypotrichosis

1 citations , September 2020 in “Journal of dermatology”

Researchers found a new mutation in the LIPH gene of a woman with a rare hair condition.

research TLR3 signaling modulates immunomodulatory property of human periodontal ligament stem cells.

January 2018

TLR3 signaling enhances the immunosuppressive properties of human periodontal ligament stem cells.

research LPA3, a unique G protein-coupled receptor for lysophosphatidic acid

31 citations , October 2010 in “Progress in lipid research”

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

research Regulatory mechanisms of LGR4 on cancer and cancer stem cell properties

May 2026 in “Discover Oncology”

Targeting LGR4 may help treat cancer by reducing cancer stem cell traits and drug resistance.

research lncRNAs UC.145 and PRKG1-AS1 Determine the Functional Output of DKK1 in Regulating the Wnt Signaling Pathway in Gastric Cancer

7 citations , May 2022 in “Cancers”

UC.145 may be a new biomarker for predicting gastric cancer.

research Lnc056 Enhances Hair Follicle Stem Cells Proliferation by Binding Transcription Factor HNRNPUL1 to Up-Regulate TRIP6 Expression.

June 2025 in “PubMed”

Lnc056 helps hair follicle stem cells grow by increasing TRIP6 expression.

research LGR5 is a Marker of Poor Prognosis in Glioblastoma and is Required for Survival of Brain Cancer Stem‐Like Cells

82 citations , July 2012 in “Brain pathology”

High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.

research Single‐center study to determine the safety and efficacy of CT‐707 in Chinese patients with advanced anaplastic lymphoma kinase‐rearranged non‐small‐cell lung cancer

5 citations , March 2020 in “Thoracic Cancer”

CT-707 is effective and safe for treating certain Chinese lung cancer patients.

research Differentiating pulmonary lymphangioleiomyomatosis from pulmonary langerhans cell histiocytosis and Birt-Hogg-Dube syndrome

1 citations , January 2013 in “Lung India”

Radiological findings help distinguish LAM, PLCH, and BHD to avoid invasive tests.

research Decision letter: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

April 2022

Lhx2 helps retinal cells respond to signals for eye development.

research A missense mutation in Lama3 causes androgen alopecia

November 2023 in “Scientific Reports”

A gene mutation in Lama3 is linked to a common type of hair loss.

research Genome-wide detection and sequence conservation analysis of long non-coding RNA during hair follicle cycle of yak

March 2020 in “Research Square (Research Square)”

Different long non-coding RNAs in yaks change during hair growth cycles and are involved in key growth pathways.