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Polymeric nanohydrogels show potential for skin drug delivery but have concerns like toxicity and regulatory hurdles.

Bicalutamide does not significantly affect liver enzymes and is a safe anti-androgen option for transfeminine individuals.

Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.

The new dressing with silver nanowires and collagen on bacterial cellulose heals wounds effectively with less toxicity and good antibacterial properties.

Plant-based compounds might be effective, low-side-effect treatments for prostate cancer by blocking a specific enzyme.

Cyclosporine is effective for skin conditions but has declined in use due to toxicity concerns.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Biomaterials can improve non-viral gene delivery by enhancing DNA uptake and reducing toxicity.

PCL nanoscaffold-based liver spheroids are effective for drug screening and studying liver toxicity.

Using too much topical minoxidil can cause serious side effects like dizziness and low blood pressure.

Improving mangiferin's solubility and delivery can enhance its health benefits.

Exposure to certain glycol ethers during pregnancy may be linked to lower verbal comprehension in children.

Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

The transfollicular route shows promise for noninvasive, targeted drug delivery but needs more research.

Cyclophosphamide often causes gastrointestinal issues, hair loss, and low blood cell counts in Chinese patients with autoimmune diseases.

Mupirocin nanoparticle-loaded hydrogel is safe and effective for healing burn wounds.

Tiny particles called extracellular vesicles show promise for skin improvement and anti-aging in facial care but face challenges like low production and lack of research.

Retinoids are effective for various skin conditions and hair loss but have serious side effects, so low doses are recommended.

Zinc is essential for plant growth and human health.

Intratesticular PRP injections are safe but not proven to improve sperm retrieval in certain infertile men.

Targeted cancer therapies can cause new side effects, requiring careful monitoring and management to ensure patient safety.

An infant with a zinc deficiency skin disorder improved with zinc treatment.

Caffeic acid helps protect rats from the harmful effects of acrylamide.

Aldesleukin can treat certain cancers and increase HIV patient CD4+ counts but often causes severe side effects.

Older men with lower levels of available testosterone are more likely to be frail.

Selenium is essential but can be harmful in excess, and China struggles with balancing its levels for health.

Alginate is great for tissue engineering because it's safe, easy to use, and helps heal tissues.

Nano-PROTACs could improve drug targeting and delivery by using nanotechnology.

Spin traps like PBN could protect skin from pollution and sunlight in cosmetics but need more research for safe use.