18 citations
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October 2021 in “Frontiers in Physiology” Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.
1 citations
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January 2020 in “Skin appendage disorders” A family was found with both Trichorhinophalangeal syndrome and Loose Anagen Syndrome, suggesting a genetic connection.
4 citations
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January 2020 in “Indian dermatology online journal” Lichen simplex chronicus on the scalp can be diagnosed by specific hair and skin signs and treated with corticosteroids and therapy.
January 2021 in “Dermatology online journal” One twin girl has Loose anagen syndrome with poorly anchored hair, diagnosed with a simple hair pull test, while her identical twin does not have the condition.
November 2016 in “Journal of The American Academy of Dermatology” Control symptoms and use safe treatments for skin conditions like lichen planopilaris and chronic cutaneous lupus erythematosus.
October 2007 in “Obstetrical & Gynecological Survey” Low-dose methotrexate, combined with surgical and local treatments, effectively treats severe vulvovaginal lichen planus.
April 2017 in “Journal of Investigative Dermatology” The PON1 192R gene variant is linked to a higher risk of psoriasis and heart disease in Western Mexico.
December 2024 in “Biochemical and Biophysical Research Communications” LMWP-PDGFA shows promise for improving hair health and treating hair loss with fewer side effects.
64 citations
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November 2012 in “EMBO reports” Lamins are vital for cell survival, organ development, and preventing premature aging.
14 citations
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January 2018 in “Skin Appendage Disorders” Upper eyelid hyperpigmentation can help diagnose facial lichen planus pigmentosus in patients with frontal fibrosing alopecia.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” Li2CO3 improved skin disease in a mouse model of Focal Dermal Hypoplasia without toxicity.
The protein's size was reduced, but more work is needed to confirm its function.
5 citations
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February 2022 in “Stem cell reports” Thymic stromal lymphopoietin (TSLP) promotes hair growth, especially after skin injury.
4 citations
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May 2009 in “Clinical and experimental dermatology” Flexural follicular lichen planus is a rare skin condition affecting body folds.
3 citations
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August 2024 in “Molecular Biology Reports” LncRNA018392 helps goat skin cells grow by increasing CSF1R.
December 2005 in “Journal of the American Academy of Physician Assistants” The woman was diagnosed with lichen planopilaris and can be treated with corticosteroids.
April 2023 in “Journal of Investigative Dermatology” RNase L suppresses regeneration in mammals.
8 citations
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July 2020 in “Journal of The American Academy of Dermatology” Patients with Lichen Planopilaris are more likely to have rosacea and skin cancer but less likely to have congestive heart failure, stroke, and glaucoma.
82 citations
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July 2012 in “Brain pathology” High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.
Low level laser or LED therapy combined with infiltrations may help hair growth.
1 citations
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April 2022 in “HCA Healthcare Journal of Medicine” Linear cutaneous lupus erythematosus on the scalp is rare, often affects young Asians, and can be treated with specific medications.
January 2019 in “Lung India” A 68-year-old woman with lupus and blood disorders improved after increased steroids and immunoglobulin treatment.
January 2009 in “Chinese Journal of Evidence-Based Pediatrics” Neonatal lupus symptoms usually resolve, but some children may develop other autoimmune diseases later.
13 citations
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July 2016 in “Pediatric Dermatology” Loose Anagen Syndrome is more common in females and may be inherited, often confused with other hair disorders, and lacks evidence for biotin treatment effectiveness.
1 citations
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December 2025 in “Baylor University Medical Center Proceedings” Leuprolide may better manage cholesterol and blood pressure in PCOS than spironolactone.
14 citations
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July 2007 in “Lupus” Multiple pregnancies prevent skin disease but worsen kidney disease in certain mice.
1 citations
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April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” Oral tofacitinib significantly improves lichen planopilaris symptoms without adverse effects.
1 citations
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July 2025 in “PubMed” Cord blood platelet-rich plasma may safely improve vulvar lichen sclerosus symptoms.
5 citations
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July 2014 in “Acta Crystallographica Section D-biological Crystallography” Mutations in the enzyme don't significantly change how it binds to its specific substances.
5 citations
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May 2011 in “European Journal of Medical Genetics” A genetic duplication on chromosome 5 was linked to a woman's unique combination of medical conditions.