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SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

Certain hormone medications can treat symptoms like acne and unwanted hair, regulate periods, and prevent pregnancy in women and teenage girls.

Older men with lower levels of available testosterone are more likely to be frail.

Ketoconazole can treat ovarian hyperandrogenism but should be used cautiously with monitoring and birth control.

Saw palmetto may cause erectile dysfunction and needs better safety monitoring.

Progesterone protects brain cells, but Provera does not.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

A man's rare adrenal tumor caused feminization and white hair, was removed surgically, and improved after treatment.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Propranolol affects heart rate and renin levels in minoxidil-treated patients.

Buserelin safely and effectively suppresses early puberty, potentially improving final height.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

17β-estradiol boosts APE1/Ref-1 secretion in cells and mice via a calcium-dependent pathway.

Finasteride safely lowers DHT levels without affecting testosterone.

Testosterone reduces knee movement, while flutamide and finasteride increase it.

High doses of cyproterone acetate increase the risk of brain tumors in women, but the risk decreases after stopping the medication.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

A new method was developed to measure and assess the activity and inhibition of the enzyme steroid 5α-reductase.

Progesterone and its metabolites can prevent seizures without major side effects.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

The trial on testosterone replacement therapy in older men faced concerns due to prostate cancer risk.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Testosterone is key for male sexual function, and treating hormone imbalances can improve sexual issues.

Removing both ovaries may better treat increased male hormone levels and related symptoms in postmenopausal women when hormone therapy doesn't work.

Androgens increase pigmentation in young hamsters, but estrogens can reverse this effect.