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GlossaryMechanical Strength

ability to resist breaking or deforming under force

Mechanical strength refers to the ability of a material to withstand forces or loads without breaking or deforming. In the context of hair, it indicates how well hair fibers can resist damage from physical actions like brushing, pulling, or styling. For professionals, it encompasses properties such as tensile strength, elasticity, and resilience, which are critical for understanding hair health and the effectiveness of hair care products.

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Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

research Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

43 citations , December 2013 in “Stem Cells”

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

research In-Silico Modelling of Transdermal Delivery of Macromolecule Drugs Assisted by a Skin Stretching Hypobaric Device

1 citations , November 2022 in “Pharmaceutical research”

The simulation showed that hypobaric pressure improves drug delivery through the skin, but stretching alone doesn't fully explain the increase.

research Faculty Opinions recommendation of Mechanical stretch induces hair regeneration through the alternative activation of macrophages.

October 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Mechanical stretching can promote hair growth by activating certain immune cells.

research Mechanical stretch induces hair regeneration through the alternative activation of macrophages

163 citations , April 2019 in “Nature Communications”

Mechanical stretching of the skin can promote hair growth by activating certain immune cells.

research LB1027 Identifying the mechanism of tension-associated tissue fibrosis based on single cell RNA sequencing on keloid scar

July 2024 in “Journal of Investigative Dermatology”

Mechanical tension worsens keloid scars by activating inflammation and fibrosis pathways.

research Hair follicle stem cells promote epidermal regeneration under expanded condition

February 2024 in “Frontiers in physiology”

Hair follicle stem cells help skin heal and grow during stretching.

research 細胞配置と力学的刺激の複合効果がもたらす毛髪および皮膚附属器官の完全生体外再生

January 2019 in “Institutional Repositories DataBase (IRDB)”

Hair follicles and skin structures were successfully regenerated in the lab using specific cell arrangements and mechanical conditions.

research Expansion of specialized epidermis induced by hormonal state and mechanical strain

3 citations , February 2015 in “Mechanisms of development”

Hormones and stretching both needed for nipple area skin growth in mice.

research Transient skin stretching stimulates immune surveillance and promotes vaccine delivery via hair follicles

September 2025 in “Cell Reports”

Skin stretching can improve vaccine delivery through hair follicles and boost immune response.

research Mechanical force drives the initial mesenchymal-epithelial interaction during skin organoid development

January 2023 in “Theranostics”

Mechanical force is important for the first contact between skin cells and hair growth in mini-organs.

research The Science of Stretching Skin and its Clinical Application

June 1997 in “The American Journal of Cosmetic Surgery”

Understanding the science of skin stretching is crucial for safe and effective hair replacement techniques.

research A randomized, controlled clinical trial of autologous stromal vascular fraction cells transplantation to promote mechanical stretch-induced skin regeneration

19 citations , April 2021 in “Stem Cell Research & Therapy”

SVF cell transplantation improves skin regeneration safely.

research Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging

9 citations , February 2021 in “Frontiers in Cell and Developmental Biology”

Older mice have stiffer skin with less elasticity due to changes in collagen and skin structure, affecting aging and hair loss.

research WISP-1 induced by mechanical stress contributes to the fibrosis and hypertrophy of ligamentum flavum via the Hedgehog-Gli1 signaling

November 2020

Mechanical stress causes ligament thickening through WISP-1 and Hedgehog signaling.

research Hair regeneration: Mechano-activation and related therapeutic approaches.

September 2025 in “PubMed”

Mechanical stimulation and new therapies show promise for hair regrowth.

research Blood in the Church: The Inquisition against Hernando Alonso

January 2011 in “Hispania Judaica bulletin”

Mechanical forces are crucial for hair regeneration in skin organoids.

research Epidermal/Dermal Separation Techniques and Analysis of Cell Populations in Human Skin Sheets

1 citations , December 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Choosing the right method to separate skin layers is key for good skin cell research.

research A Raman spectroscopy investigation of the resilience of hair cuticular scales under uniaxial stress

March 2026 in “Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials”

Hair cuticles remain stable and resilient under stress due to strong protein content and crosslinking.

research Multiscale modelling of human hair

49 citations , June 2004 in “Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences”

Human hair becomes weaker and stretches more easily at higher temperatures.

research Expression of estrogen, androgen, and glucocorticoid receptors in recent striae distensae

67 citations , December 2009 in “International Journal of Dermatology”

Hormonal changes in skin may cause stretch marks.

research 898 Homeostatic activation of epidermal HSD11b1 affects skin innervation and non-histaminergic itch

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

HSD11b1 affects skin nerves and increases non-histaminergic itch.

research Stiffness-Controlled Thermoresponsive Hydrogels for Cell Harvesting with Sustained Mechanical Memory

22 citations , January 2017 in “Advanced Healthcare Materials”

The hydrogels help harvest cells while preserving their mechanical memory, which could improve wound healing.

research Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture

2 citations , February 2024 in “Nature cell biology”

Mechanical forces are crucial for shaping cells and forming tissues during development.

WISP-1 Induced by Mechanical Stress Contributes to Fibrosis and Hypertrophy of the Ligamentum Flavum Through Hedgehog-Gli1 Signaling

research WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

36 citations , June 2021 in “Experimental & Molecular Medicine”

Targeting Hedgehog signaling may help treat ligamentum flavum fibrosis.

Metformin Promotes Mechanical Stretch-Induced Skin Regeneration by Improving the Proliferative Activity of Skin-Derived Stem Cells

research Metformin Promotes Mechanical Stretch-Induced Skin Regeneration by Improving the Proliferative Activity of Skin-Derived Stem Cells

1 citations , May 2022 in “Frontiers in medicine”

Metformin helps improve skin regeneration by increasing the growth of skin stem cells.

research Mechanical forces in skin disorders

65 citations , March 2018 in “Journal of Dermatological Science”

Skin problems can be caused or worsened by physical forces and pressure on the skin.

research Skin aging as a mechanical phenomenon: The main weak links

41 citations , May 2018 in “Nutrition and healthy aging”

Skin aging is largely due to differences in stiffness and elasticity between skin layers, leading to wrinkles.

research Insights on the mechanical behavior of keratin fibrils

13 citations , May 2016 in “International journal of biological macromolecules”

Keratin's mechanical properties are influenced by hydrogen bonds and secondary structure, and can be improved with the SPD-2 peptide.

Systems Approach to Human Hair Fibers: Interdependence Between Physical, Mechanical, Biochemical, and Geometric Properties of Natural Healthy Hair

research Systems Approach to Human Hair Fibers: Interdependence Between Physical, Mechanical, Biochemical and Geometric Properties of Natural Healthy Hair

11 citations , February 2019 in “Frontiers in Physiology”

Hair properties are interconnected; a comprehensive, cross-disciplinary approach is essential for understanding hair behavior.

research Hair resistance to mechanical wear

3 citations , January 2021 in “Wear”

Hair's resistance to wear varies by ethnicity and treatment, with less wear indicating stronger hair.