The human scalp has different types of pigment cells in hair follicles with varying abilities to produce pigment.
86 citations
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August 2000 in “Pigment cell research” Melanocyte activity in hair follicles is linked to the hair growth cycle, being active in growth phases and inactive in rest phases.
February 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” Hair follicles protect melanocytes from sun damage, helping them replenish skin.
41 citations
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April 2019 in “PLOS genetics” CD34+ and CD34- melanocyte stem cells have different regenerative abilities.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” A specific group of early-stage melanocytes is reduced in vitiligo-affected skin, which may explain treatment resistance.
August 2023 in “International Journal of Molecular Sciences” The human scalp hair bulb contains different types of melanocytes with varying abilities to produce melanin.
127 citations
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November 2010 in “Pigment cell & melanoma research” We need more research on human hair follicle pigmentation, not just mouse models.
April 2024 in “Pigment cell & melanoma research” Different types of resting melanocyte stem cells have unique characteristics and vary in their potential to become other cells.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Different types of inactive melanocyte stem cells exist with unique characteristics and potential to develop into other cells.
9 citations
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May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Human melanocytes have unique traits that affect melanoma development and prognosis.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” The study found markers indicating that cells responsible for hair color are differentiating in specific areas of the hair follicle.
5 citations
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May 2023 in “Frontiers in Cell and Developmental Biology” Integrin α6 helps identify different neural crest cell types in the skin.
6 citations
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August 2019 in “PLOS ONE” Gambogic Amide helps maintain hair color and promotes hair growth.
86 citations
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February 2012 in “Journal of Clinical Investigation” Stem cells in hair follicles are diverse and change throughout the hair cycle.
146 citations
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May 2002 in “The American journal of pathology” Cathepsin L is essential for normal hair growth and development.
3 citations
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November 2023 in “Frontiers in cell and developmental biology” Melanocytes are important for skin and hair color and protect the skin from UV damage.
April 2023 in “Dermatology practical & conceptual” Lenalidomide helps hair follicle stem cells turn into melanocytes, which may improve repigmentation in vitiligo.
June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” The gene Tfap2b is essential for creating a type of stem cell in zebrafish that can become different pigment cells.
210 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.
109 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.
67 citations
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November 2019 in “Nature Communications” Oncogenic melanocyte stem cells can develop into melanoma similar to human cases.
24 citations
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March 2018 in “Pigment Cell & Melanoma Research” The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.
18 citations
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August 2021 in “PLoS ONE” Melanocyte progenitor cells are found in human fat tissue and can become mature melanocytes, which may help treat skin issues.
2 citations
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December 2016 in “Experimental cell research” The research found a way to identify and study skin cells with stem cell traits, revealing they behave differently in culture and questioning current stemness assessment methods.
401 citations
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January 2013 in “Postepy Dermatologii I Alergologii” The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.
240 citations
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April 2011 in “Pigment Cell & Melanoma Research” Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.
29 citations
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January 2013 in “International Journal of Medical Sciences” Wnt10b helps hair follicle cells mature and produce pigment.
8 citations
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January 2017 in “Stem Cells International” A protein called sFRP4 from skin cells stops the development of pigment-producing cells in hair.
8 citations
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February 2013 in “Central European Journal of Biology” Melanocytes are diverse cells important for pigmentation and skin health, influenced by genetics and environment.
7 citations
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June 2021 in “Cell Proliferation” Low oxygen levels improve the function of hair and skin cells when they are in direct contact.