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GlossaryMelanoma Cells

cancerous cells originating in pigment-producing melanocytes

Melanoma cells are cancerous cells that originate in melanocytes, the cells responsible for producing melanin, the pigment that gives skin its color. These cells can grow uncontrollably and spread to other parts of the body, making melanoma one of the most dangerous forms of skin cancer. Early detection and treatment are crucial for improving survival rates.

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research The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells

48 citations , April 2021 in “Pharmaceuticals”

Liposomal curcumin improves skin cancer treatment effectiveness while sparing normal cells.

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research Carvone Decreases Melanin Content by Inhibiting Melanoma Cell Proliferation via the Cyclic Adenosine Monophosphate (cAMP) Pathway

12 citations , November 2020 in “Molecules”

Carvone helps treat skin issues by reducing melanin and stopping harmful cell growth.

research Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells

11 citations , February 2018 in “Archives of Pharmacal Research”

Finasteride reduces melanin production, possibly treating hyperpigmentation and melanoma, but needs more safety research.

P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis

research 1272 p21Waf1/Cip1 is differentially expressed in epidermal versus follicular melanocytes and melanoma cells and is phenotypically regulated by UVB-mediated apoptosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The protein p21 is more abundant in normal skin cells than in melanoma cells and may help protect against melanoma, with UVB light affecting its levels.

research Stimulation of melanogenesis by Carthamus tinctorius floret extract in B16F10 murine melanoma cells

January 2013 in “วารสารเภสัชศาสตร์อีสาน (Isan Journal of Pharmaceutical Sciences, IJPS)”

Safflower extract increases melanin production in certain skin cells without harming them.

research 644 Tumor cell adhesion as a risk factor for SLN metastasis and predictor of disease recurrence in primary cutaneous melanoma

April 2016 in “Journal of Investigative Dermatology”

Tumor cell adhesion is linked to higher risk of SLN metastasis and melanoma recurrence, and a model including these factors predicts these outcomes better than one with just clinical data.

Dual Aspects of B Cells in Tumor Immunity: Positive and Negative Regulation Against B16 Melanoma

research Dual aspects of B cells in tumor immunity; B cells are capable of positive and negative regulation for tumor immunity against B16 melanoma

April 2017 in “Journal of Dermatological Science”

B cells can both help and hinder the body's defense against melanoma.

research Human melanocyte development and melanoma dedifferentiation at single cell resolution

9 citations , May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Human melanocytes have unique traits that affect melanoma development and prognosis.

research A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease

67 citations , November 2019 in “Nature Communications”

Oncogenic melanocyte stem cells can develop into melanoma similar to human cases.

research ‘Malignant melanoma microecosystem’: Immunohistopathological insights into the stromal cell phenotype

8 citations , January 2011 in “Experimental and Therapeutic Medicine”

Stromal cells in melanoma promote tumor growth and spread.

research Epidermal and Hair Follicle Progenitor Cells Express Melanoma-Associated Chondroitin Sulfate Proteoglycan Core Protein

51 citations , February 2004 in “Journal of Investigative Dermatology”

MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.

research Nestin is expressed in HMB‐45 negative melanoma cells in dermal parts of nodular melanoma

9 citations , April 2010 in “The Journal of Dermatology”

Nestin helps identify certain melanoma cells in nodular melanoma.

research Dormant tumor cells in ret transgenic mouse melanoma model and their interaction with memory T cells

January 2012 in “heiDOK (Heidelberg University)”

Dormant melanoma cells in mice interact minimally with memory T cells due to a suppressive tumor environment.

Cell of Origin Contributes to Melanoma Diversity

research 1379 Cell of origin contributes to the melanoma diversity

April 2018 in “Journal of Investigative Dermatology”

Different types of stem cells in the skin contribute to the variety of melanoma forms.

research Ethanol extract of asiasari radix preferentially induces apoptosis in G361 human melanoma cells by differential regulation of p53

2 citations , August 2019 in “BMC Complementary and Alternative Medicine”

Asiasari radix extract may be a potential treatment for melanoma because it selectively triggers cell death in melanoma cells by affecting p53 regulation.

research Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells

37 citations , November 2017 in “Medical Sciences”

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

research 0959 Effects of M1 homeopathic complex on human melanoma cells

July 2025 in “Journal of Investigative Dermatology”

M1 homeopathic complex may help slow melanoma cell growth.

research Effect of adipose-derived stem cell-conditioned medium on the proliferation and migration of B16 melanoma cells

23 citations , June 2015 in “Oncology Letters”

Adipose-derived stem cell-conditioned medium can reduce melanoma cell growth and spread.

Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma

research Fibroblast heterogeneity and functions: insights from single-cell sequencing in wound healing, breast cancer, ovarian cancer and melanoma

March 2024 in “Frontiers in genetics”

Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.

research Differential effects of dehydroepiandrosterone (DHEA) between mouse and human melanoma cell lines

January 2016

DHEA inhibits growth in both mouse and human melanoma cells but works differently in each.

research Morphologic comparison of cultured human epidermis melanocytes,amelanotic melanocytes from hair follicles and mouse melanoma cells observed by atomic force microscope

January 2003 in “Linchuang pifuke zazhi”

Melanin granules can be expelled by exocytosis.

research A case of bullous pemphigoid in a malignant melanoma patient following an increased Th2/Th1 ratio in peripheral blood cells after nivolumab treatment

1 citations , October 2023 in “European Journal of Dermatology”

Combining hair transplantation with PRP is more effective for treating hair loss than hair transplantation alone.