April 2023 in “Dermatology practical & conceptual” Lenalidomide helps hair follicle stem cells turn into melanocytes, which may improve repigmentation in vitiligo.
1 citations
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January 2005 in “Experimental Dermatology” MC-1R in skin cells may influence inflammation and collagen production.
April 2024 in “The Indonesian Biomedical Journal” Melanocyte stem cells from non-affected skin in vitiligo patients can become functional melanocytes for potential therapy.
3 citations
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April 2009 in “PubMed” Melatonin may protect rat hair follicles from damage caused by oxidative stress after a burn.
April 2016 in “Journal of Investigative Dermatology” SOX4 is crucial for the development of melanoma.
Cialis and Finasteride could be repurposed to treat aggressive melanoma.
59 citations
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April 2016 in “Cell Reports” EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.
Retinoids or their analogs could treat skin pigmentation disorders like melasma and vitiligo.
109 citations
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October 2007 in “Journal of pineal research” Melatonin helps regulate hair growth and protects the hair follicle from stress.
April 2026 in “International Journal of Advanced Biochemistry Research” Aegle marmelos fruit extract can protect against arsenic toxicity in mice.
December 2025 in “Scientific Reports” α-Mangostin can naturally lighten skin by reducing melanin.
January 1999 in “Praxis sociológica” Melanocyte stem cells can become melanoma, resembling human melanoma.
4 citations
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May 2018 in “International Journal of Molecular Sciences” The research showed how melanocytes develop, move, and respond to UV light, and their stem cells' role in hair color and skin cancer risk.
January 1972 in “Open PRAIRIE (South Dakota State University)” Mimosine is toxic to animals, causing hair loss, infertility, and growth issues, but its exact harmful mechanism is unclear.
1 citations
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February 2023 in “International Journal of Molecular Sciences” Melatonin, the sleep hormone, can help treat skin conditions like dermatitis, hyperpigmentation, and scalp disorders, and may also aid in skin aging prevention and regeneration. However, it's not recommended for asthma due to its pro-inflammatory effect.
240 citations
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April 2011 in “Pigment Cell & Melanoma Research” Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.
January 2011 in “Yearbook of Dermatology and Dermatologic Surgery” Thicker melanomas and nodular types are more likely to spread to sentinel lymph nodes.
3 citations
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September 2022 in “Veterinary Dermatology” Melatonin implants did not effectively prevent hair loss in dogs.
March 2025 in “International Journal of Molecular Sciences” Melatonin promotes hair growth and quality by enhancing hair follicle development and reducing stress.
12 citations
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February 2010 in “Tetrahedron Letters” New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.
3 citations
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November 2022 in “Experimental dermatology” Melatonin may inhibit melanoma growth and has potential as a cancer therapy aid, but its effects on human skin pigmentation need more research.
9 citations
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July 2020 in “Journal of Animal Physiology and Animal Nutrition” Melatonin given to pregnant rabbits improved their babies' fur quality.
September 2025 in “Indian Dermatology Online Journal” Melatonin, primarily known for regulating circadian rhythms, also provides significant antioxidant, anti-inflammatory, and immunomodulatory benefits, making it a promising treatment for dermatological conditions such as atopic dermatitis, melasma, androgenic alopecia, and psoriasis. It reduces oxidative stress, aids in DNA repair, and offers anti-aging and photoprotective effects. Studies have shown positive outcomes, particularly in androgenic alopecia, where topical melatonin has been effective in promoting hair growth. However, further research is needed to determine optimal dosing, long-term safety, and how it compares to traditional treatments.
April 2016 in “Journal of Investigative Dermatology” MEK and BRAF inhibitors increase sebum production and accumulation, which could cause acne-like side effects.
June 2026 in “Drug Delivery and Translational Research” The solid microneedle booster improves hair regrowth and follicle enrichment when used with minoxidil.
4 citations
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August 2018 in “American journal of otolaryngology” Transgender women on estrogen therapy can develop melasma and need proper skin care.
9 citations
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May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Human melanocytes have unique traits that affect melanoma development and prognosis.
37 citations
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July 2002 in “Archives of Pathology & Laboratory Medicine” Tyrosinase and gp100 proteins can help diagnose and treat melanoma.
185 citations
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February 2018 in “Journal of Investigative Dermatology” Melatonin may benefit skin health and could be a promising treatment in dermatology.
3D models from confocal microscopy improve melanoma detection on sun-damaged skin.