77 citations
,
January 1989 in “Clinical Infectious Diseases” Toxic Shock Syndrome progresses quickly, often involves multiple organs, and is linked to Staphylococcus aureus toxins, with treatment options available but diagnostic challenges remaining.
75 citations
,
January 2014 in “Archiv Der Pharmazie” Jasmonic acid and its derivatives play important roles in plant health and have potential uses in medicine and agriculture.
75 citations
,
May 2013 in “Journal of the American Academy of Dermatology” Zinc deficiency in children can cause skin issues and can be serious if not diagnosed and treated properly.
74 citations
,
September 1980 in “Medical Clinics of North America” Toxic epidermal necrolysis is a severe skin condition often caused by drugs, with complex treatment and a high risk of death, but survivors usually heal without scars.
72 citations
,
January 2001 in “Drugs” Minoxidil and finasteride treat hair loss; more research needed for other options.
70 citations
,
July 2005 in “Journal of Ethnopharmacology” Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.
68 citations
,
July 2011 in “Journal of Biochemistry/The journal of biochemistry” New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.
68 citations
,
March 2008 in “Experimental dermatology” The new assay can track and measure melanosome transfer between skin cells, confirming filopodia's role in this process.
68 citations
,
April 2002 in “Journal of Alternative and Complementary Medicine” Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.
67 citations
,
July 2016 in “Reviews in Endocrine and Metabolic Disorders” Stress can worsen skin conditions by affecting hormone levels and immune response.
65 citations
,
August 2007 in “Experimental Dermatology” Human hair follicles can make and process prostaglandins, which may affect hair growth.
65 citations
,
April 2002 in “Journal of Alternative and Complementary Medicine” Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.
61 citations
,
May 2016 in “Scientific reports” The peptide IMT-P8 can effectively deliver proteins into the skin and cells for potential skin treatments.
61 citations
,
May 2014 in “International journal of pharmaceutics” Nanocrystals improve skin penetration and stability of caffeine, suggesting a new method for delivering similar substances through the skin.
61 citations
,
May 2010 in “Integrative Cancer Therapies” There is no clear recommendation for using selenium in cancer patients; it may be beneficial to correct low selenium levels before treatment.
61 citations
,
March 2009 in “The Journal of the American Board of Family Medicine” Early diagnosis and treatment of discoid lupus erythematosus improve outcomes.
60 citations
,
July 2020 in “ACS Nano” Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.
60 citations
,
April 2006 in “International Journal of Dermatology” Surgical methods like suction blister grafting and split-thickness skin grafting are highly successful for vitiligo repigmentation, but choosing the right patients is crucial for success.
60 citations
,
June 1997 in “Journal of The American Academy of Dermatology” Apoptosis is crucial for healthy skin and treating skin diseases.
59 citations
,
May 2017 in “Scientific reports” ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.
59 citations
,
August 1998 in “International Journal of Dermatology” Genetics and hormones cause hair loss; finasteride treats it safely.
57 citations
,
January 2014 in “Cold Spring Harbor Perspectives in Medicine” Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.
57 citations
,
November 2006 in “International Journal of Cancer” A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.
57 citations
,
January 2003 in “Clinical and experimental dermatology” Postmenopausal frontal fibrosing alopecia is a type of hair loss in postmenopausal women that may stop on its own but has no effective treatment.
57 citations
,
January 1980 in “Journal of Cardiovascular Pharmacology” Minoxidil treats high blood pressure and side effects can be managed.
56 citations
,
February 2006 in “American journal of physiology. Cell physiology” Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
55 citations
,
September 2017 in “Expert Opinion on Drug Discovery” Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.
55 citations
,
June 2009 in “Journal of Pharmaceutical Sciences” Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.
54 citations
,
July 2017 in “Scientific Reports” JMJD3 and NF-κB activate Notch1, which is essential for skin cell movement and wound healing.
54 citations
,
December 2007 in “Best Practice & Research Clinical Endocrinology & Metabolism” Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.