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GlossaryMesenchymal Stem Cells

cells that can become bone, cartilage, or fat cells

Mesenchymal Stem Cells (MSCs) are a type of multipotent stem cell found in various tissues, including bone marrow, fat, and umbilical cord tissue. They have the ability to differentiate into a variety of cell types, such as bone, cartilage, and fat cells, making them valuable for regenerative medicine and tissue engineering.

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research From hair to pancreas: transplanted hair follicle mesenchymal stem cells express pancreatic progenitor cell markers in a rat model of acute pancreatitis.

8 citations , January 2021 in “PubMed”

Hair follicle stem cells may help treat acute pancreatitis by reducing inflammation and aiding regeneration.

research Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species

6 citations , September 2009 in “European journal of histochemistry”

CD90 is present on specific cells in dog hair follicles.

research Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species

15 citations , September 2009 in “European Journal of Histochemistry”

CD90 is abundantly present on stem-like cells in dog hair follicles.

research Enhancing hair regrowth using rapamycin-primed mesenchymal stem cell-derived exosomes

June 2025 in “Theranostics”

Rapamycin-primed exosomes can significantly boost hair regrowth.

research 09-P006 Epithelial–mesenchymal interactions promote hair follicle neogenesis and a new stem cell niche in adult corneal epithelium

August 2009 in “Mechanisms of Development”

Adult hair follicle cells can create new hair follicles from corneal cells with the right support.

research Use of human induced pluripotent stem cell-derived CD271+CD90+ mesenchymal stem cells for the generation of hair inductive dermal cells

September 2016 in “Journal of dermatological science”

Human induced pluripotent stem cells can be used to create cells that help grow hair.

Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in C57BL/6 Mice Through Upregulation of the RAS/ERK Signaling Pathway

research Exosomes derived from Umbilical cord mesenchymal stem cell promote hair regrowth in C57BL6 mice through upregulation of the RAS/ERK signaling pathway

November 2024 in “Journal of Translational Internal Medicine”

Exosomes from stem cells help hair regrowth by activating a specific signaling pathway.

Towards a Consensus Potency Assay for Mesenchymal Stromal Cells: A Matrix Analysis of Cell Source, Donor Variability, and Inflammatory Stimuli to Refine Surrogate Markers of Immunomodulation

research Towards a consensus potency assay for mesenchymal stromal cells: a matrix analysis of cell source, donor variability and inflammatory stimuli to refine surrogate markers of immunomodulation

3 citations , May 2019 in “Cytotherapy”

ATIR101 improves survival in stem cell transplant patients; Australian stem cell treatment decisions are influenced by regulation changes.

The Role of Box A of HMGB1 in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-Aging Therapy

research The Role of Box A ofHMGB1in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-aging Therapy

1 citations , January 2023 in “In vivo/In Vivo”

Box A of HMGB1 can improve stem cell function, aiding anti-aging therapy.

research Rat hair follicle-constituting cells labeled by a newly-developed somatic stem cell-recognizing antibody: a possible marker of hair follicle development.

4 citations , February 2013 in “PubMed”

A3 antibody helps identify key cells in rat hair follicle development.

research Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles

14 citations , April 2021 in “International journal of molecular sciences”

Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.

research Stem Cell Therapy in Veterinary Dermatology

2 citations , April 2013

Stem cell therapy shows promise for treating skin issues in animals.

Application of Extracellular Vesicles From Mesenchymal Stem Cells Promotes Hair Growth by Regulating Human Dermal Cells and Follicles

research Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles

6 citations , July 2022 in “World journal of stem cells”

Using extracellular vesicles from stem cells can help hair grow by affecting scalp cells and hair follicles.

research Comparative Characterization of Hair Follicle Dermal Stem Cells and Bone Marrow Mesenchymal Stem Cells

151 citations , February 2006 in “Stem Cells and Development”

Hair follicles can be a good source of stem cells like those from bone marrow.

research Human Induced Pluripotent Stem Cell–Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo

64 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human stem cells can help form hair follicles in mice.

research Enrichment and characterization of human dermal stem/progenitor cells using collagen type IV

11 citations , June 2012 in “Journal of Dermatological Science”

Scientists identified a group of human skin cells with high growth and regeneration potential.

research Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation

7 citations , January 2022 in “Biomedicines”

Cells from the lower part of hair follicles are a promising, less invasive option for immune system therapies.

Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

research Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

174 citations , November 2016 in “Cell stem cell”

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

research Modulating Mesenchymal Stem Cell Behavior Using Human Hair Keratin-Coated Surfaces

23 citations , January 2015 in “Stem cells international”

Coating surfaces with human hair keratin improves the growth and consistency of important stem cells for medical use.

research Single-cell RNA-seq highlights heterogeneity in human primary Wharton’s jelly mesenchymal stem/stromal cells cultured in vitro

116 citations , April 2020 in “Stem Cell Research & Therapy”

Wharton's jelly stem cells show diverse traits and functions.

research CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance

11 citations , September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific group of skin stem cells was found to help maintain hair follicle cells.

Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells

research Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells

42 citations , February 2017 in “Scientific Reports”

Researchers found a way to create cells from stem cells that act like human cells important for hair growth and could be used for hair regeneration treatments.

research From hair to liver: emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling pathway to inhibit pathological HSC activation

4 citations , February 2022 in “PeerJ”

Hair follicle stem cell transplants can reverse liver cirrhosis by blocking harmful cell activation.

Therapeutic Effects of Human Amniotic Mesenchymal Stem Cell-Derived Exosomes on Stem Cell Proliferation in Irradiated Salivary Glands via the Wnt Pathway

research Therapeutic effects of human amniotic mesenchymal stem cell-derived exosomes on stem cell proliferation in irradiated salivary glands via the Wnt pathway

January 2026 in “Open Life Sciences”

Exosomes from stem cells help repair irradiated salivary glands by boosting cell growth.

research Label Retention Identifies a Multipotent Mesenchymal Stem Cell-Like Population in the Postnatal Thymus

17 citations , December 2013 in “PLoS ONE”

The postnatal thymus has cells like mesenchymal stem cells that can become different cell types and help maintain thymus structure.

In Vitro Cultured Human-Derived HFMSCs Show Potential to Promote Wound Healing

research In vitro cultured human-derived HFMSCs have shown the potential to promote wound

January 2026 in “China National GeneBank DataBase”

Human hair follicle stem cells can help heal wounds faster.

research Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats

3 citations , January 2021 in “Oxidative Medicine and Cellular Longevity”

Nrf-2-modified stem cells from hair follicles significantly improve ulcerative colitis in rats.

Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

research Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle

11 citations , October 2021 in “Stem Cell Research & Therapy”

Hair follicle stem cells reduced hair loss and inflammation in mice with a condition similar to human alopecia.

research 965 In search of the common mechano-chemical pathways during the regeneration of spiny (acomys cahirinus) and laboratory (mus musculus) mouse skin

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Spiny mice regenerate skin better than laboratory mice due to larger hair bulges, more stem cells, and different collagen ratios.

research The homing of exogenous hair follicle mesenchymal stem cells into hair follicle niches

6 citations , November 2023 in “JCI Insight”

Exogenous stem cells can effectively integrate into hair follicles, promoting hair growth.