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GlossaryMetabolic Dysfunction

abnormalities in body's metabolic processes affecting energy conversion

Metabolic dysfunction refers to abnormalities in the body's metabolic processes, which can lead to issues like insulin resistance, obesity, and abnormal lipid levels. These disruptions can affect how the body converts food into energy and how it manages essential functions, potentially contributing to conditions such as type 2 diabetes and cardiovascular disease.

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Animal Models and the Developmental Origins of Polycystic Ovary Syndrome: Increasing Evidence for the Role of Androgens in Programming Reproductive and Metabolic Dysfunction

research Animal Models and the Developmental Origins of Polycystic Ovary Syndrome: Increasing Evidence for the Role of Androgens in Programming Reproductive and Metabolic Dysfunction

44 citations , May 2012 in “Endocrinology”

High levels of androgens during early development may cause PCOS-like symptoms.

research Metabolic dysfunction in obese Hispanic women with polycystic ovary syndrome

13 citations , April 2015 in “Human Reproduction”

Obese Hispanic women with PCOS are at higher risk for metabolic problems than non-Hispanic white women.

research Metabolic dysfunction in female mice with disruption of 5α-reductase 1

11 citations , January 2017 in “Journal of Endocrinology/Journal of endocrinology”

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

research Cutaneous Clues to Metabolic Dysfunction: Dermatological Manifestations of Diabetes and Insulin Resistance in Clinical Practice

March 2026 in “Current Research in Diabetes & Obesity Journal”

Skin conditions can signal diabetes and insulin resistance.

Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated With Androgenetic Alopecia in Adults With Stronger Effects in Women and Unhealthy Lifestyles

research Metabolic dysfunction-associated steatotic liver disease is associated with androgenetic alopecia in adults with stronger effects in women and unhealthy lifestyles

November 2025 in “Scientific Reports”

Liver disease is linked to hair loss, especially in women and those with unhealthy lifestyles.

Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease from a Young Age Due to a Rare Genetic Disorder, Familial Partial Lipodystrophy: A Case Report and Review of the Literature

research Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) from a Young Age Due to a Rare Genetic Disorder, Familial Partial Lipodystrophy: A Case Report and Review of the Literature

December 2024 in “Livers”

Recognizing rare causes of MASLD is crucial for effective treatment and preventing complications.

research Mitochondrial dysfunction in metabolic syndrome and inflammatory skin disease

October 2024 in “Our Dermatology Online”

Mitochondrial dysfunction links metabolic syndrome and inflammatory skin diseases, suggesting targeted therapies and lifestyle changes.

research Hair loss due to pollution, micro metabolic dysfunction, epigenetics and role of nutrients

September 2024 in “Brazilian Journal of Hair Health”

Nutrients can help improve hair growth and thickness caused by pollution.

research Mitochondrial Dysfunction in Lichen Planopilaris with Focus on Oxidative Stress and Metabolic Reprogramming

January 2025 in “International journal of research studies in biosciences”

Mitochondrial dysfunction and oxidative stress may play a role in Lichen Planopilaris.

research 1431 Skin aging and hair follicle stem cell dysfunction caused by T cells with defective mitochondrial metabolism

April 2023 in “Journal of Investigative Dermatology”

Defective T cell metabolism can cause early skin aging and poor hair follicle stem cell function.

research Skin as a Window to Endocrine Dysfunction: Dermatological and Metabolic Interactions in Polycystic Ovary Syndrome

April 2026 in “JOJ Dermatology & Cosmetics”

Skin issues in PCOS signal hormone problems, and combined treatments improve outcomes.

research Glycolytic Dysfunction in Granulosa Cells and Its Contribution to Metabolic Dysfunction in Polycystic Ovary Syndrome

3 citations , June 2025 in “Drug Design Development and Therapy”

Targeting glycolysis may help treat PCOS by improving insulin sensitivity and ovarian function.

research Global prevalence of sexual dysfunction among women with metabolic syndrome: a systematic review and meta-analysis

5 citations , July 2023 in “Journal of Diabetes & Metabolic Disorders”

Insulin Resistance and Beta-Cell Dysfunction and the Relationship with Cardio-Metabolic Disorders Among Women with Polycystic Ovary Syndrome

research Insulin resistance and β-cell dysfunction and the relationship with cardio-metabolic disorders among women with polycystic ovary syndrome

4 citations , August 2018 in “Clinical Endocrinology”

Women with PCOS have more insulin resistance and are more likely to have heart-related health issues, with insulin resistance being a bigger factor than β-cell problems.

Integrative Nutritional Mechanisms of Keyora Lycopene 23 in 1 Men's Multi-Vitamin in Erectile Dysfunction, Male Infertility, Prostatic Disorders, and Metabolic Dysregulation

research Integrative Nutritional Mechanisms of Keyora Lycopene 23 in 1 Man's Multi-Vitamin in Erectile Dysfunction, Male Infertility, Prostatic Disorders, and Metabolic Dysregulation

November 2025 in “Zenodo (CERN European Organization for Nuclear Research)”

Keyora Lycopene 23 in 1 Man's Multi-Vitamin improves male reproductive health and metabolism.

research Integrative Nutritional Mechanisms of Keyora Lycopene 23 in 1 Man's Multi-Vitamin in Erectile Dysfunction, Male Infertility, Prostatic Disorders, and Metabolic Dysregulation

November 2025 in “Zenodo (CERN European Organization for Nuclear Research)”

Keyora Lycopene 23 in 1 multi-vitamin improves men's reproductive and metabolic health.

Transgenerational Transmission of Reproductive and Metabolic Dysfunction in Male Progeny of Polycystic Ovary Syndrome

research Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome

1 citations , May 2023 in “Cell reports medicine”

Sons of mothers with polycystic ovary syndrome (PCOS) have a higher risk of obesity and insulin resistance, possibly due to certain genes and factors passed down from their mothers.

Inhibition of Autophagy-Lysosomal Function Exacerbates Microglial and Monocyte Lipid Metabolism Reprogramming and Dysfunction After Brain Injury

research Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury

September 2025

Blocking autophagy worsens lipid buildup and dysfunction in brain cells after injury.

research 42003 Hormonal profile of androgenetic alopecia in adolescents and its association with metabolic dysfunction: single center retrospective study

September 2023 in “Journal of The American Academy of Dermatology”

Adolescents with hair loss show different hormone levels by sex and often have related metabolic issues.

research Cerebral Ischemia Related to Isotretinoin; Venlafaxine-Induced Alopecia; Cognitive Dysfunction with Tolterodine; Retinal Artery Occlusion after Injection of Long-Acting Risperidone; Olanzapine-Induced Chylomicronemia Presenting as Pancreatitis; Metabolic Effects of the Atypical Antipsychotics – an Editorial; Another Drug-Induced Pancreatitis – This One Caused by a Tyrosine Kinase Inhibitor; Suicide Attempts Related to Antidepressant Medications

November 2007 in “Hospital pharmacy”

The conclusion is that healthcare professionals should report adverse drug reactions to improve medication safety and patient care.

research Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome

25 citations , June 2012 in “Endocrine”

PCOS may start before birth, involves metabolic issues, and can be treated with drugs like metformin and lifestyle changes.

research Effective treatment of skin and metabolic manifestations of hyperandrogenism: a comprehensive improvement of quality of life

2 citations , April 2019 in “Медицинский совет”

Combined oral contraceptives improve skin, hormone levels, and quality of life in women with PCOS.

research Anais Congresso Nacional Sobre Obesidade e Síndrome Metabólica

August 2025 in “Scire Salutis”

Obesity can cause acne in kids and teens due to hormonal and metabolic changes.

Post-Finasteride Syndrome: When Will We Get the Courage to Fight the Dictating Pharma Industry Despite Awareness of Sexual, Neurological, and Metabolic Side Effects in Young Men for Over a Decade

research Post-Finasteride Syndrome – When will we Get the Courage to Fight the Dictating Pharma Industry – Despite Awareness of “Sexual, Neurological and Metabolic Side Effects in Young Men for Over a Decade”

January 2020 in “Archives of urology”

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men

31 citations , January 2017 in “Advances in Experimental Medicine and Biology”

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

research Intracrine androgen biosynthesis, metabolism and action revisited

131 citations , September 2017 in “Molecular and Cellular Endocrinology”

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

research Raising threshold for diagnosis of polycystic ovary syndrome excludes population of patients with metabolic risk

14 citations , July 2016 in “Fertility and Sterility”

Changing the diagnosis criteria for PCOS might miss women at risk for related health issues.

Polycystic Ovary Syndrome Phenotypes and Metabolic Dysfunction Relationship

research POLİKİSTİK OVER SENDROMU FENOTİPLERİ VE METABOLİK DİSFONKSİYON İLİŞKİSİ

March 2023 in “İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi”

Obesity is linked to higher metabolic syndrome and LH/FSH ratios, but no significant differences exist among PCOS phenotypes.

research Metabolic and Vascular Inflammation in Alopecia Areata: Linking Uric Acid, Lipid Imbalance and ICAM ‐1 Upregulation

December 2025 in “Experimental Dermatology”

Improving blood vessel health and controlling uric acid may help manage alopecia areata.

research Female sexual dysfunction in androgenetic alopecia: Case-control study

5 citations , July 2016 in “Canadian Urological Association journal”

Hair loss in women linked to higher sexual dysfunction risk.