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Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study

research Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study

November 2023 in “Life”

Eriocitrin and silymarin might be effective for hair loss treatment and need more research.

research A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function

October 2023 in “Journal of pharmaceutical investigation”

Finasteride dosages should be adjusted based on CYP3A5 genotype and liver function to avoid side effects.

Sex-Related Differences in the Pharmacological Response in SARS-CoV-2 Infection, Dyslipidemia, and Diabetes Mellitus: A Narrative Review

research Sex-Related Differences in the Pharmacological Response in SARS-CoV-2 Infection, Dyslipidemia, and Diabetes Mellitus: A Narrative Review

June 2023 in “Pharmaceuticals”

Men and women respond differently to drugs for COVID-19, high cholesterol, and diabetes, which suggests a need for personalized treatments.

research Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment

153 citations , June 2015 in “GenomeBiology.com”

The environment around the time of conception can change the VTRNA2-1 gene in a way that lasts for years and may affect disease risk.

research A Transition State Analogue of 5′-Methylthioadenosine Phosphorylase Induces Apoptosis in Head and Neck Cancers

75 citations , June 2007 in “Journal of Biological Chemistry”

MT-DADMe-ImmA can selectively kill head and neck cancer cells without harming normal cells.

research SARS-CoV-2 Non-Structural Proteins and Their Roles in Host Immune Evasion

52 citations , September 2022 in “Viruses”

SARS-CoV-2 proteins help the virus avoid the immune system, delaying response and increasing inflammation.

research The Role of Nutrition on Thyroid Function

43 citations , July 2024 in “Nutrients”

A balanced diet with essential micronutrients is crucial for healthy thyroid function.

research Is There a Histone Code for Cellular Quiescence?

27 citations , October 2021 in “Frontiers in Cell and Developmental Biology”

There might be a specific histone code for cellular quiescence, but more research is needed.

research Effective holistic characterization of small molecule effects using heterogeneous biological networks

11 citations , April 2023 in “Frontiers in Pharmacology”

Integrating biological networks improves drug repurposing and ADR prediction.

research A network pharmacology-based approach to explore mechanism of action of medicinal herbs for alopecia treatment

8 citations , February 2022 in “Scientific Reports”

Medicinal herbs might treat hair loss by affecting genes and pathways related to lipid and glycerophospholipid metabolism.

research Analysis of Genome DNA Methylation at Inherited Coat Color Dilutions of Rex Rabbits

7 citations , January 2021 in “Frontiers in genetics”

Inherited color dilution in rabbits is linked to DNA methylation changes.

research Identification and Characterization of Two Se6OMTs from Stephania epigaea Offer Novel Insights into the Biosynthetic Pathway of Cepharanthine

3 citations , February 2025 in “Metabolites”

The research found enzymes in Stephania epigaea that help make cepharanthine.

research Hair for brain trade-off, a metabolic bypass for encephalization

3 citations , September 2014 in “SpringerPlus”

Human hair loss may have evolved to help increase brain size.

research ENZYMES

1 citations , November 2011 in “British journal of pharmacology”

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

research Two-Stage Machine Learning-Based GWAS for Wool Traits in Central Anatolian Merino Sheep

November 2025 in “Agriculture”

Machine learning can effectively identify genes to improve wool quality in sheep.

research Prevalence of Cobalt in the Environment and Its Role in Biological Processes

2 citations , October 2023 in “Biology”

Cobalt is important for health but too much or too little can cause health problems, and its environmental buildup is a concern.

research Emerging Topical and Systemic JAK Inhibitors in Dermatology

277 citations , December 2019 in “Frontiers in Immunology”

JAK inhibitors show promise for treating skin disorders like alopecia, eczema, and psoriasis.

research Characterization of a new tissue-engineered human skin equivalent with hair

221 citations , June 1999 in “In Vitro Cellular & Developmental Biology - Animal”

research Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators

129 citations , January 2004 in “Journal of medicinal chemistry”

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

research The Auxin-Regulated CrRLK1L Kinase ERULUS Controls Cell Wall Composition during Root Hair Tip Growth

109 citations , February 2018 in “CB/Current biology”

ERULUS controls root hair growth by regulating cell wall composition and pectin activity.

research Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease

85 citations , March 2008 in “Journal of Cell Science”

The mutation causing Hutchinson-Gilford progeria syndrome leads to severe skin problems and early death in mice.

research Injectable Biomaterials for Dental Tissue Regeneration

82 citations , May 2020 in “International Journal of Molecular Sciences”

Injectable biomaterials can effectively regenerate dental tissues.

research Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

79 citations , December 2017 in “Cosmetics”

Effective sunscreen formulations can reduce skin absorption and enhance protection.

research Characterization of the in vitro, ex vivo, and in vivo Efficacy of the Antimicrobial Peptide DPK-060 Used for Topical Treatment

78 citations , May 2019 in “Frontiers in Cellular and Infection Microbiology”

DPK-060 in poloxamer gel effectively treats skin infections, but nanocarriers don't enhance its efficacy.

research Epidermal Stem Cells do not Communicate Through Gap Junctions

73 citations , January 2002 in “Journal of Investigative Dermatology”

Epidermal stem cells don't use gap junctions to communicate.

research Exploring Acne Treatments: From Pathophysiological Mechanisms to Emerging Therapies

68 citations , May 2024 in “International Journal of Molecular Sciences”

Personalized acne treatments and new therapies show promise for better results.

research Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

57 citations , November 2024 in “Aggregate”

Smart hydrogels can improve diabetic wound healing by adapting to wound conditions and providing controlled treatment.

research Ethnodermatological use of medicinal plants in India: From ayurvedic formulations to clinical perspectives – A review

57 citations , October 2021 in “Journal of ethnopharmacology”

Indian herbal medicine shows promise for treating skin diseases but needs more research to prove effectiveness.

research Advances and Prospects for Hydrogel-Forming Microneedles in Transdermal Drug Delivery

48 citations , July 2023 in “Biomedicines”

Hydrogel-forming microneedles are promising for safe, efficient, and controlled drug delivery through the skin.

research
Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

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