research Cellular actions of testosterone in vascular cells: Mechanism independent of aromatization to estradiol
Testosterone affects vascular cells directly without converting to estradiol.
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research Crystal Structure and Synthesis of 17α-Hexanoyloxy-16β-methylpregna-4,6-diene-3,20-dione
A new compound that could treat various androgen-related conditions was created and analyzed.
research Muscle pain in a woman with congenital adrenal hyperplasia due to 21-hydroxylase deficiency resolved with testosterone therapy. A case report with 10 years of follow-up
Testosterone therapy improved symptoms in a woman with congenital adrenal hyperplasia.
research Beneficios y riesgos de los implantes de testosterona en mujeres: revisión sistemática de la literatura
The risks of testosterone implants in women outweigh the benefits.
research Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone
Metabolite 7 is a strong inhibitor for Alzheimer's disease management.
research Development and Evaluation of Niosomal Gel for TransdermalApplication of steroidal API
The niosomal gel effectively delivers testosterone through the skin with fewer side effects.
research Systemic testosterone induces structural, immunological, and sex steroid receptor changes in human XX skin
Testosterone makes XX skin more like male skin by changing its structure and cell makeup.
research Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design
Mutants of CYP154C2 enzyme significantly improved steroid conversion efficiency.
research Synthesis, Characterization and Evaluation of 5α, 6β-Dihalo Androsterone Derivatives as 5α-Reductase Inhibitors
Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.
research FDA declines approval of testosterone drug for third time
The FDA rejected a testosterone drug again due to safety concerns.
research 5α-Metabolism in Finasteride-Treated Subjects and Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency
Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.
research Reevaluating Testosterone Therapy in Women
Testosterone therapy is safe and effective for women but is limited by cost and lack of awareness.
research Pharmacokinetics of a new testosterone transdermal delivery system, TDS®‐testosterone in healthy males
The new testosterone patch works as well as the gel.
research Testosterone Therapy for Osteoporosis in Men
Testosterone therapy may help men with osteoporosis.
research 5 Alpha-Reductase Inhibitor
5 Alpha-Reductase Inhibitors reduce the effects of testosterone by blocking its conversion into a stronger form.
research 215. Plasma testosterone and dihydrotestosterone in cryptorchid boys treated with HCG
research Direct quantitative digital autoradiography of testosterone metabolites in the pilosebaceous unit: an environmentally advantageous trace radioactive technology
The method accurately measures testosterone metabolites with high sensitivity and low environmental impact.
research Methylmalonic Acidemia: Can Treatment be Improved?
Looser dietary restrictions can improve growth and reduce illness in methylmalonic acidemia patients.
research Cross‐Sex Hormone Therapy in Trans Persons Is Safe and Effective at Short‐Time Follow‐Up: Results from the European Network for the Investigation of Gender Incongruence
Hormone therapy for trans individuals is effective and generally safe in the short term.
research Testosterone enantate
A man developed hair loss from testosterone treatment but improved with additional medication.
research Exploring the efficacy of testosterone undecanoate in male children with 5α‐reductase deficiency
Testosterone undecanoate safely and effectively increased penis size in male children with 5-alpha-reductase deficiency.
research More about X‐linked testicular feminization of the mouse as a noninducible (is) mutation of a regulatory locus: 5α‐androstan‐3α‐17ß‐diol as the true inducer of kidney alcohol dehydrogenase and ß‐glucuronidase
A specific metabolite, not a receptor protein, triggers the production of certain kidney enzymes, but this process is disrupted in mice with a mutation causing testicular feminization.
research Invalidation of a commercially available human 5α-dihydrotestosterone immunoassay
The DHT immunoassay is unreliable due to high cross-reactivity with testosterone.
research Crystal Structure and Synthesis of 17.ALPHA.-Acetoxy-6,7-epoxypregn-4-ene-3,20-dione
A new compound was made that might help treat diseases related to male hormones.
research Pharmacological Profile of 9,11-Dehydrocortexolone 17α-Butyrate (CB-03-04), a New Androgen Antagonist with Antigonadotropic Activity
CB-03-04 shows promise as a treatment for prostate issues due to its strong anti-androgen effects.
research Hormonal Treatment of Transgender Women with Oral Estradiol
Oral estradiol works for many transgender women but needs personalized dosing and monitoring.
research The five-year effects of testosterone replacement therapy on lipid profile and glucose tolerance among hypogonadal men in Japan: a case control study
Testosterone replacement therapy improved blood sugar and fat levels without raising prostate cancer risk in Japanese men with low testosterone.
research Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis
Oral testosterone therapy raises heart risk more than other methods.
research Disappearance of a virilizing adrenal tumor following therapy with cyproterone acetate
A woman's adrenal tumor disappeared after treatment with cyproterone acetate.
research Detectability of oxandrolone, metandienone, clostebol and dehydrochloromethyltestosterone in urine after transdermal application
Transdermal exposure to certain steroids can be detected in urine for up to 14 days.