research Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata
Non-immune factors play a significant role in alopecia areata.
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research Any route for melanoblasts to colonize the skin!
Melanoblasts migrate to the skin using various pathways, and understanding this process could help with skin disease research.
research Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites
The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
research A comparison of transcriptomic patterns measured in the skin of Chinese fine and coarse wool sheep breeds
Fine wool sheep have more genes for wool quality, while coarse wool sheep have more for skin and muscle traits.
research From gene to therapy in spinal and bulbar muscular atrophy: Are we there yet?
Effective treatments for spinal and bulbar muscular atrophy are not yet available; more research is needed.
research Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model
Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.
research Advances in the Study of Stem-Cell-Enriched Hair Follicle Bulge Cells: A Review Featuring Characterization and Isolation of Human Bulge Cells
Scientists have made progress in understanding hair follicle stem cells, identifying specific genes and markers, and suggesting their use in treating hair and skin conditions.
research Hair Coloration by Gene Regulation: Fact or Fiction?
Gene regulation could revolutionize hair color by altering pigmentation from within.
research Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration
Nanog gene boosts stem cells, helps hair growth, and may treat hair loss.
research Exploring the neural mechanisms of finasteride: a proteomic analysis in the nucleus accumbens
Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.
research Gene Expression in Rat Dermal Papilla Cells: Analysis of 2529 ESTs
Rat dermal papilla cells have unique genes crucial for hair growth.
research The concealed side of caspases: beyond a killer of cells
Caspases do more than kill cells; they also help in cell growth and disease, and targeting them could lead to new treatments.
research Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and personalized treatment
Early diagnosis and personalized treatment for PCOS are crucial, especially for young women in West Bengal, India.
research Development of growth factor-incorporating liposomes for integration into scaffolds as a method to improve tissue regeneration
Liposomal carriers can improve tissue regeneration by stabilizing and retaining growth factors.
research Protective effects of human umbilical cord blood‑derived mesenchymal stem cells against dexamethasone‑induced apoptotic cell death in hair follicles
Stem cells from umbilical cord blood may prevent hair loss caused by certain medications.
research New potential chemotherapy for ovarian cancer — Combined therapy with WP 631 and epothilone B
The new chemotherapy combination of WP 631 and Epothilone B shows enhanced effectiveness against ovarian cancer but requires more research on its safety.
research Genomewide differential expression profiling of long non-coding RNAs in androgenetic alopecia in a Chinese male population
Found different long non-coding RNAs in balding Chinese men, which may help create new treatments.
research Enrichment and Characterization of Human Dermal Stem/Progenitor Cells by Intracellular Granularity
Scientists identified a unique type of human skin stem cell that could help with tissue repair.
research Collagen-Heparin-FGF2-VEGF Scaffolds Induce a Regenerative Gene Expression Profile in a Fetal Sheep Wound Model
Collagen-heparin-FGF2-VEGF scaffolds can improve skin healing.
research Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments
iPSCs help understand and treat neurodevelopmental disorders.
research Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient
The study found genetic differences related to hair development that may explain hair loss in a patient with Trichorhinophalangeal syndrome type I.
research Impact of taxol on dermal papilla cells — A proteomics and bioinformatics analysis
Taxol damages hair growth cells, causing hair loss.
research Root hair growth from the pH point of view
pH changes are crucial for root hair growth because they affect enzymes and proteins that control the cell wall and growth.
research Novel circRNAs from cashmere goats: Discovery, integrated regulatory network, and their putative roles in the regeneration and growth of secondary hair follicles
Certain circular RNAs help cashmere goats grow more hair.
research Transcriptome Profiling of Human Follicle Dermal Papilla Cells in response to Porphyra-334 Treatment by RNA-Seq
Porphyra-334 may help reduce wrinkles and promote hair growth.
research Cutaneous transcriptome analysis in NIH hairless mice
Key genes linked to hair growth and cancer were identified in hairless mice.
research Site of beige (bg) and leaden (ln) pigment gene expression determined by recombinant embryonic skin grafts and aggregation mouse chimaeras employing sash (Wsh) homozygotes
Beige and leaden pigment genes act within melanocytes, affecting pigment patterns.
research Revisiting the significance of keratin expression in complex epithelia
Keratin genes change gradually during skin cell development and should be used carefully as biomarkers.
research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides)
Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.
research Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells
Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.