52 citations
,
February 1985 in “Archives of Dermatology” Minoxidil absorbs poorly through skin, with low risk of side effects at 1-2% concentration.
25 citations
,
June 1990 in “Journal of Pharmaceutical Sciences” Longer contact time increases minoxidil absorption, but doesn't affect metabolism.
18 citations
,
October 2005 in “International Journal of Pharmaceutics” Adding a small amount of TPGS to minoxidil can help hair growth, but too much TPGS reduces this effect and increases minoxidil in the blood.
1 citations
,
June 2022 in “Pharmaceutics” Minoxidil's absorption is too variable for it to be a reliable reference drug.
April 2025 in “American Journal of Case Reports” Improper use of minoxidil can cause excessive hair growth.
30 citations
,
April 1990 in “Clinical Pharmacology & Therapeutics” Tretinoin cream boosts minoxidil absorption, possibly improving hair loss treatment.
January 2005 in “Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)” 0.5% TPGS boosts hair growth with minoxidil, but 2% TPGS increases minoxidil absorption.
January 2022 in “Carolina Digital Repository (University of North Carolina at Chapel Hill)” 181 citations
,
July 2004 in “Journal of controlled release” Smaller nanoparticles improve minoxidil absorption through hair follicles.
27 citations
,
September 2018 in “Medicines” Oleic acid nanovesicles improve minoxidil absorption in hair follicles for alopecia treatment.
2 citations
,
January 2012 in “Hair therapy & transplantation” DDAIP-HCl significantly increases minoxidil absorption into the skin.
44 citations
,
January 1997 in “British Journal of Dermatology” Stopping 5% topical minoxidil can reverse unwanted hair growth on the face and limbs.
18 citations
,
January 1997 in “British Journal of Dermatology” 5% topical minoxidil can cause severe body hair growth, which disappears after stopping treatment.
10 citations
,
February 2016 in “Anais Brasileiros de Dermatologia” Topical minoxidil can cause excessive hair growth in children, so use it carefully.
4 citations
,
January 2009 in “International journal of trichology” Minoxidil topical foam is a better, less irritating treatment for hair loss.
October 2015 in “Elsevier eBooks” Minoxidil is effective for hair growth and safe for long-term use.
July 2022 in “Journal of Investigative Dermatology” The new minoxidil hydrogel is a promising alternative for hair loss treatment, with similar effectiveness and less skin irritation.
44 citations
,
October 1989 in “International Journal of Pharmaceutics” Minoxidil's effectiveness decreases as vehicle evaporates; concentration and thermodynamic activity matter.
39 citations
,
April 2010 in “International Journal of Pharmaceutics” Nanoparticles improve minoxidil skin permeation, but more research needed for effective hair growth.
26 citations
,
May 2012 in “Pharmaceutical Development and Technology” PEVs effectively deliver minoxidil through skin.
23 citations
,
April 1991 in “Journal of The American Academy of Dermatology” Minoxidil solution can cause skin irritation and allergies in some users.
19 citations
,
March 2011 in “Cutaneous and Ocular Toxicology” Some chemicals absorbed through the skin can cause serious health problems.
18 citations
,
March 1984 in “BMJ” Minoxidil helps hair regrowth in alopecia, but more research needed.
17 citations
,
October 2013 in “F1000Research” A 2-year-old boy grew excessive hair after using minoxidil for hair loss, but it improved when the treatment stopped.
7 citations
,
August 2024 in “JAAD reviews.” Minoxidil can cause unwanted hair growth, so personalized care and support are important.
2 citations
,
November 2017 in “Journal of Cosmetic and Laser Therapy” JetPeel-assisted minoxidil improves hair density and thickness more than minoxidil alone.
March 2026 in “Mini-Reviews in Medicinal Chemistry” Oral minoxidil can be improved for hair loss treatment with personalized strategies and new technologies.
March 2026 in “International Journal of Dermatology” Children can develop excessive hair growth from indirect contact with minoxidil, but it usually reverses after stopping exposure.
August 2025 in “Macromolecular Bioscience” Microneedles with minoxidil and nitric oxide improve hair growth effectively and painlessly.
April 2025 in “Research Square (Research Square)” Minoxidil microinfusion lowered diastolic blood pressure in patients.