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GlossaryMitochondrial Activity

processes in cells that produce energy for various functions

Mitochondrial activity refers to the processes carried out by mitochondria, the energy-producing structures within cells. These processes include the production of ATP (adenosine triphosphate), which is the primary energy currency of the cell, through a series of biochemical reactions known as cellular respiration. Efficient mitochondrial activity is crucial for cell function and overall energy metabolism, impacting everything from muscle performance to hair growth.

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research Novel complex of cosmetic ingredients with promising action in preventing hair loss and follicular aging through mechanism involving enrichment of WNT/signaling, mitochondrial activity, and stem cells maintenance

8 citations , November 2020 in “Journal of Cosmetic Dermatology”

The ingredients may help prevent hair loss and aging by boosting hair growth signals and reducing stress and hormone effects.

research Epidermolysis Bullosa Simplex Keratinocytes Show Disturbed Mitochondrial Positioning and Activity

3 citations , January 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin cells from people with Epidermolysis Bullosa Simplex have abnormally placed and less active mitochondria.

The Bacterial Metabolite, Butyrate, Prolongs Anagen and Promotes Autophagy, Mitochondrial Activity, Melanogenesis and Antimicrobial Peptide Production in Human Scalp Hair Follicles

research 558 The Bacterial Metabolite, Butyrate, Prolongs Anagen and Promotes Autophagy, Mitochondrial Activity, Melanogenesis and Antimicrobial Peptide Production in Human Scalp Hair Follicles

November 2022 in “Journal of Investigative Dermatology”

Butyrate helps hair grow longer, improves hair cell health, increases pigment production, and boosts hair's natural defenses.

research Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

222 citations , August 2014 in “Cell Metabolism”

Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.

research A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity

98 citations , December 2015 in “The Journal of Cell Biology”

Keratin is crucial for skin barrier formation and affects mitochondrial function.

research Hair growth enhancement via mitochondrial activation by Mito‐activator complex

February 2026 in “International Journal of Cosmetic Science”

The Mito-Activator Complex boosts hair growth by activating mitochondria.

research 1433 Epithelially derived, mitochondrial MPZL3 negatively regulates murine and human hair follicle cycling

April 2023 in “Journal of Investigative Dermatology”

A protein called MPZL3 in mitochondria slows down hair growth and could be a target for treating hair growth disorders.

Investigation on Antimicrobial, Antioxidant, and Anti-Cancerous Activity of Agaricus Bisporus Derived Beta-Glucan Against Cervical Cancer Cell Line

research Investigation on antimicrobial, antioxidant, and anti-cancerous activity of Agaricus bisporus derived β-Glucan against cervical cancer cell line

2 citations , September 2022 in “Cellular and molecular biology”

Agaricus bisporus derived β-Glucan could be an effective cervical cancer treatment with antimicrobial and antioxidant properties.

research Lactate dehydrogenase activity drives hair follicle stem cell activation

202 citations , August 2017 in “Nature cell biology”

Lactate production is important for activating hair growth stem cells.

research Cholesterol homeostasis in hair follicle keratinocytes is disrupted by impaired ABCA5 activity

June 2023 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

Impaired ABCA5 activity disrupts cholesterol balance in hair follicle cells, affecting hair growth.

research 811 Mitochondrial MPZL3 in the inner root sheath regulates human hair follicle cycling ex vivo

1 citations , July 2024 in “Journal of Investigative Dermatology”

MPZL3 protein affects hair growth cycles and could help manage hair loss.

research Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

133 citations , November 2018 in “Aging”

Azithromycin and Roxithromycin can remove aging cells and may help with anti-aging.

research Leptin and the skin: a new frontier

108 citations , July 2009 in “Experimental Dermatology”

Leptin may improve skin regeneration and hair growth, and help reverse skin aging.

research Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

91 citations , August 2014 in “Development”

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

research The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo

17 citations , April 2016 in “Journal of Investigative Dermatology”

KB2115 (eprotirome) can safely extend the hair growth phase without damaging cells or changing hair color.

research Argan (Argania Spinosa) press cake extract enhances cell proliferation and prevents oxidative stress and inflammation of human dermal papilla cells

14 citations , June 2021 in “Journal of dermatological science”

Argan press cake extract might help grow hair and protect hair cells from damage and inflammation.

research Stem Cells on Alert: Priming Quiescent Stem Cells after Remote Injury

13 citations , July 2014 in “Cell stem cell”

Stem cells can be primed to respond faster to injury through mTORC1 signaling, enhancing muscle regeneration.

research Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging

7 citations , May 2022 in “Frontiers in Cell and Developmental Biology”

Epigenetic and metabolic changes affect stem cell function and aging in skin.

research Collective heterogeneity of mitochondrial potential in contact inhibition of proliferation

3 citations , August 2023 in “Biophysical Journal”

Mitochondrial activity varies in cells before they stop growing, affecting their growth potential.

research Iron Deficiency in Immune-Mediated Inflammatory Skin Diseases: A Missing Link Between Systemic Inflammation, Immunometabolism, and Disease Burden

March 2026 in “Cells”

Iron deficiency worsens inflammatory skin diseases by disrupting iron balance and increasing inflammation.

Hair Thickness Growth Effect of Adenosine Complex in Male and Female Patterned Hair Loss via Inhibition of Androgen Receptor Signaling

research Hair Thickness Growth Effect of Adenosine Complex in Male-/Female-Patterned Hair Loss via Inhibition of Androgen Receptor Signaling

June 2024 in “International journal of molecular sciences”

Adenosine complex helps increase hair thickness and density in hair loss.

research Review of low-level laser therapy's impact

January 2024 in “International Journal of Physics and Applications”

Low-level laser therapy can boost cell activity and energy production.

research 1032 Characterization of the human scalp hair follicle microbiome reveals differential spatial distribution, abundance and viability of intrafollicular microbiota and modulation of hair growth and metabolism by staphylococcus epidermidis

April 2023 in “Journal of Investigative Dermatology”

Staphylococcus epidermidis affects hair growth and metabolism, suggesting it could help manage hair growth issues.

Evaluation of the Impact of Significant Weight Loss by Very Low-Calorie Ketogenic Diet on Metabolic, Inflammatory, Hormonal, and Seminal Parameters of Obese Men

research Avaliação do impacto da redução significativa de peso pela dieta cetogênica de muito baixa caloria nos parâmetros metabólicos, inflamatórios, hormonais e seminais de homens obesos

March 2023

A very low-calorie ketogenic diet led to weight loss and improved metabolic and hormonal health in obese men, with better sperm motility.

research Low-level laser therapy in immune-mediated skin disease: a narrative review

December 2022 in “Medical lasers”

Low-level laser therapy may help with hair regrowth in alopecia areata but its effectiveness for psoriasis and atopic dermatitis needs more research.

research Low Level Laser Treatment for Patterned Hair Loss: A Systematic Review

December 2018 in “Zenodo (CERN European Organization for Nuclear Research)”

Low-level laser therapy may help hair growth, but more research is needed.

research Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways

October 2025 in “Cell Proliferation”

IL10_ApoEVs improve skin healing and reduce scarring.

research Anti-Amnesia-like Effect of Pinus densiflora Extract by Improving Apoptosis and Neuroinflammation on Trimethyltin-Induced ICR Mice

September 2023 in “International journal of molecular sciences”

Pinus densiflora extract may help improve memory and reduce brain inflammation.

research Exogenous Alpha-Ketoglutaric Acid Alleviates the Rabbit Dermal Papilla Cell Oxidative Damage Caused by Hydrogen Peroxide Through the ERK/Nrf2 Signaling Pathway

4 citations , April 2025 in “Antioxidants”

Alpha-ketoglutarate protects rabbit skin cells from oxidative damage by activating a specific cell pathway.

research 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging

3 citations , April 2025 in “International Journal of Molecular Sciences”

TSG from Polygonum multiflorum may help with anti-aging by protecting the brain, heart, bones, and hair.